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Changes in the dynamics of the muscle thin filaments observed by neutron scattering

Fujiwara, Satoru; Matsuo, Tatsuhito; Yamada, Takeshi*; Takahashi, Nobuaki*; Kamazawa, Kazuya*; Kawakita, Yukinobu  ; Shibata, Kaoru  

In order to investigate the role of protein dynamics in the regulatory mechanism of muscle contraction, we carried out neutron inelastic scattering experiments on the native thin filaments (NTF) in the presence and absence of Ca$$^{2+}$$ and F-actin using the dynamics analysis spectrometer DNA at J-PARC. The mean square displacements estimated from the elastic incoherent neutron scattering measurements showed that NTF in the -Ca$$^{2+}$$ state is more dynamically disordered than in the +Ca$$^{2+}$$ state. Comparison with F-actin suggests that the difference arises from the regulatory proteins. The dynamic change in the regulatory proteins suggests that the dynamics of these proteins plays an important role in the regulatory mechanism of muscle contraction.

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