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Genetic analysis of novel DNA cross-link repair genes common to ${it Deinococcus}$ and ${it Thermus}$

Onodera, Takefumi*; Sato, Katsuya; Ota, Toshihiro*; Narumi, Issey*

The ${it ygjD}$ and ${it yeaZ}$ orthologs are highly conserved in eubacteria, and the former is also widely found in the genomes of archaea and eukaryotes. However, their functions are still poorly understood. ${it Deinococcus radiodurans}$ and ${it Thermus thermophilus}$ possess the both orthologs hereafter ${it DrygjD}$, ${it DryeaZ}$, ${it TtygjD}$ and ${it TtyeaZ}$, respectively. We have reported that the ${it DrygjD}$ and ${it DryeaZ}$ disruptants show extreme sensitivity to mitomycin C (MMC), which causes interstrand DNA cross-links. In this study, we constructed ${it TtygjD}$ and ${it TtyeaZ}$ gene expression plasmids and the resultant plasmids were introduced into the ${it DrygjD}$ and ${it DryeaZ}$ disruptant strains. To investigate whether ${it ygjD}$ and ${it yeaZ}$ orthologs share the common function in ${it D. radiodurans}$ and ${it T. thermophilus}$, these generated strains were challenged by MMC.

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English

Journal

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JAEA-Review 2013-059, JAEA Takasaki Annual Report 2012

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Pages

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P. 111

Publication Year/Month

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2014/03

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Keywords

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no keyword

Research Facility

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コバルト60照射施設

Press Release

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Article of JAEA R&D Review

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Accesses

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- Accesses

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