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Role of DNA repair and effect of herbal extract on LOH induced by ion beam radiations in ${it Saccharomyces cerevisiae}$

出芽酵母におけるイオンビーム誘発ゲノム不安定性とDNA修復機構の役割

布柴 達男*; 坂田 弥生*; 山内 理子*; 佐藤 勝也; 小野寺 威文*; 鳴海 一成*

Nunoshiba, Tatsuo*; Sakata, Yayoi*; Yamauchi, Ayako*; Sato, Katsuya; Onodera, Takefumi*; Narumi, Issey*

The LOH (loss of heterozygosity) induction by various ion beam radiations was investigated in diploid ${it Saccharomyces cerevisiae}$. The ion beams $$^{12}$$C$$^{5+}$$, $$^{12}$$C$$^{6+}$$, $$^{4}$$He$$^{2+}$$ and $$^{40}$$Ar$$^{13+}$$ at the lowest dose (75, 75, 200 and 150 Gy, respectively), which had 30$$sim$$50% lethality, induced LOH with 10-fold higher frequency. The LOH induction was predominantly ($$sim$$ 90%) resulted from homologous recombination. Pol$$zeta$$ may be involved in the induction of LOH by ion beam radiations, because in the strain lacking Rev3, only slight induction of LOH was observed. In addition, the effects of 14 herbal extracts were examined on iron-beam radiation induced LOH, and ethanol extract of ${it Eucalyptus regnans}$ possessed inhibitory effect on LOH induced by $$^{12}$$C$$^{5+}$$ ion-beam radiation with the manner dependent on doses of extract.

使用言語

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English

掲載資料名

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JAEA-Review 2013-059, JAEA Takasaki Annual Report 2012

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P. 118

発行年月

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2014/03

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no keyword

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研究データの公開先DOI

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使用施設

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TIARA(イオン照射研究施設)

広報プレスリリース

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論文解説記事
(成果普及情報誌)

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受委託・共同研究相手機関

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国際基督教大学

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- Accesses

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