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Free energy profile of nucleosomal DNA unwrapping

Kono, Hidetoshi; Sakuraba, Shun; Ishida, Hisashi

Eukaryotic genome is compactly stored into a tiny nucleus of cell in the form of protein-DNA complex. This protein-DNA complex is called as nucleosome which is composed of a histone octamer formed by two copies each of the four core histones H3, H4, H2A and H2B and about 150 bp of DNA wrapping almost twice around the octamer. This compact form, however, has to be unwrapped in transcription, DNA duplication and DNA repair processes. To study the detailed molecular mechanism, free energy profiles for unwrapping nucleosomal DNA on several nucleosomes were calculated. So far, we estimated that a cost for unwrapping the outer DNA is 0.1 to 0.4 kcal/mol/1bp, consistent with a value experimentally obtained. In the meeting, we will report the cost for unwrapping the inner DNA.

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