Complexation of lutetium-177 with bifunctional chelators in the presence of Mg, Cu, and Yb
Mg, Cu及びYb存在下におけるLu-177と二官能性キレート剤との錯形成
渡辺 智; 橋本 和幸; 石岡 典子
Watanabe, Satoshi; Hashimoto, Kazuyuki; Ishioka, Noriko
As part of basic studies for the production of
Lu capable of labeling of
Lu-1,4,7,10-tetraazacyclododecan-N,N',N'',N'''-tetraacetic acid (DOTA)-antibody,
Lu complexation of DOTA and diethylenetriamine-N,N,N',N'',N''-pentaacetic acid (DTPA) was investigated in the presence of competing metals: Mg, Cu, and Yb in addition to Ca, Fe, and Zn. The inhibition of
Lu complexation by the competing metals was in the order of Mg, Ca
Fe
Yb
Cu, Zn and Mg, Ca
Zn
Fe
Cu
Yb with DOTA and DTPA, respectively. Consequently, the elimination of Mg and Ca from the
Lu final solution produced was not found to be necessary, while the elimination of Cu, Fe, Zn and Yb from the
Lu final solution was found to be necessary. On the basis of the knowledge obtained, the method of elimination of the competing metals will be developed.