• help
  • PC | SP
  • JP | EN
          
Refine your search：     
Report No.
 - 
Clear All
Return to the previous page

Production of $$^{67}$$Cu for cancer therapy using fast neutrons from $$^{nat}$$C(d,n) reaction

Hashimoto, Kazuyuki; Kawabata, Masako; Saeki, Hideya; Tsukada, Kazuaki  ; Sato, Nozomi*; Motoishi, Shoji*; Nagai, Yasuki; Watanabe, Satoshi; Ishioka, Noriko

Copper-67 is an attractive radionuclide for cancer therapy, because of emissions of medium energy $$beta$$ particle (a mean energy of 141 keV) and $$gamma$$ rays (91, 93, 185 keV) suitable for imaging, and its appropriate half-life (62 hours). However, the use of $$^{67}$$Cu for clinical researches has been limited due to the difficulty in obtaining sufficient quantities. In this study, we have investigated the production of $$^{67}$$Cu by the $$^{68}$$Zn(n,x)$$^{67}$$Cu reaction (x = n'p, d) using fast neutrons from $$^{nat}$$C(d,n) reaction. The highly purified $$^{67}$$Cu was obtained by the two columns separation method (chelate resin chelex-100 and anion exchange resin AG1-X8). Furthermore, the labelling of DOTA and TETA which are useful bifunctional ligands for the labelling monoclonal antibodies was succeeded in more than 97% yield.

Language

 :

Japanese

Journal

 :

Volume

 :

Number

 :

Pages

 :

Publication Year/Month

 :

Meeting title

 :

2014日本放射化学会年会・第58回放射化学討論会

Held date

 :

2014/09

Location (city)

 :

名古屋

Location (country)

 :

日本

Patent information

 :

PDF

 :


Paper URL

 :

DOI for research data

 :

Keywords

 :

RI製造; 加速器中性子

Research Facility

 :

RI製造棟  ;TIARA(イオン照射研究施設)

Press Release

 :

Article of JAEA R&D Review

 :

Cooperating Institute

 :

Accesses

 :

- Accesses

InCites™

 :

Altmetrics

 :

[CLARIVATE ANALYTICS], [WEB OF SCIENCE], [HIGHLY CITED PAPER & CUP LOGO] and [HOT PAPER & FIRE LOGO] are trademarks of Clarivate Analytics, and/or its affiliated company or companies, and used herein by permission and/or license.

Return to the previous page