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Report No.

Spectrum of radiation-induced clustered non-DSB damage; A Monte Carlo track structure modelling and calculations

Watanabe, Ritsuko; Rahmanian, S.*; Nikjoo, H.*

To calculate the spectrum of initial base damage induced by selected electrons and ions, Monte Carlo track structure method was used to simulate the radiation induced DNA damage in a cell mimetic condition based on a single track action. We present relative yield of strand breaks and base damage for selected monoenergetic electrons 100 eV - 100 keV, photons C$$_{K}$$, Al$$_{K}$$ and Ti$$_{K}$$; and some selected ions (3.2 MeV/u proton; 0.74 and 2.4 MeV/u $$^{4}$$He; 29 MeV/u $$^{14}$$N, and 950 MeV/u $$^{56}$$Fe). Data are presented for simple and complex types of DNA damage. The ratios of yields of base damage to SSBs were estimated to be about 2-4 independent on the LETs examined. The contribution of base damage to the complexity of damage site was shown to be significant. The data can be used for testing mechanistic models of DNA repair kinetics and in particular the base excision repair.



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