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SPECT imaging of mice with $$^{99m}$$Tc-radiopharmaceuticals obtained from $$^{99}$$Mo produced by $$^{100}$$Mo(n,2n)$$^{99}$$Mo and fission of $$^{235}$$U

$$^{100}$$Mo(n,2n)$$^{99}$$Mo反応で製造した$$^{99}$$Moと$$^{235}$$Uの核分裂で製造した$$^{99}$$Moから調製した$$^{99m}$$Tc放射性薬剤のマウスSPECT画像

橋本 和幸; 永井 泰樹; 川端 方子; 佐藤 望*; 初川 雄一; 佐伯 秀也; 本石 章司*; 太田 雅之; 今野 力; 落合 謙太郎; 河内 幸正; 太田 朗生; 椎名 孝行; 竹内 宣博; 芦野 広樹; 中原 勇人*

Hashimoto, Kazuyuki; Nagai, Yasuki; Kawabata, Masako; Sato, Nozomi*; Hatsukawa, Yuichi; Saeki, Hideya; Motoishi, Shoji*; Ota, Masayuki; Konno, Chikara; Ochiai, Kentaro; Kawauchi, Yukimasa; Ota, Akio; Shiina, Takayuki; Takeuchi, Nobuhiro; Ashino, Hiroki; Nakahara, Yuto*

The distribution of $$^{99m}$$Tc-radiopharmaceutical in mouse was obtained with SPECT for the first time using $$^{99m}$$Tc, which was separated by thermochromatography from $$^{99}$$Mo produced via the $$^{100}$$Mo(n,2n)$$^{99}$$Mo reaction with accelerator neutrons. The SPECT image was comparable with that obtained from a fission product $$^{99}$$Mo. Radionuclidic purity and radiochemical purity of the separated $$^{99m}$$Tc and its aluminum concentration met the United States Pharmacopeia regulatory requirements for $$^{99m}$$Tc from the fission product $$^{99}$$Mo. These results provide important evidence that $$^{99m}$$Tc radiopharmaceutical formulated using the $$(n,2n)$$ $$^{99}$$Mo can be a promising substitute for the fission product $$^{99}$$Mo. A current and forthcoming problem to ensure a reliable and constant supply of $$^{99}$$Mo in Japan can be partially mitigated.

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パーセンタイル:58.15

分野:Physics, Multidisciplinary

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