Refine your search�ソスF     
Report No.
 - 

Synthesis of radiobrominated amino acid derivatives via silicon-bromine exchange reaction

Watanabe, Shigeki; Yamada, Keiichi*; Watanabe, Saki*; Oku, Hiroyuki*; Moriguchi, Tomohisa*; Shinozuka, Kazuo*; Ishioka, Noriko

Br-76 (half-life: 16.1 h) is of interest for in vivo imaging using PET. Therefore, Br-76 labeled peptides which have high affinity to tumor cells are promising PET tracers for tumor imaging. Tin-halogen exchange reaction have been used for radiobromination. However, it is likely that synthesis of stannylated peptides is difficult because stannyl group is readily eliminated under acidic condition. Silicon-carbon bond is resistant to acid, leading us to employ silicon-bromine exchange reaction for the radiobromination. In this study, we are aiming to synthesize a radiobrominated phenylalanine derivative via the silicon-bromine exchange reaction as a feasible study.

Accesses

:

- Accesses

InCites™

:

Altmetrics

:

[CLARIVATE ANALYTICS], [WEB OF SCIENCE], [HIGHLY CITED PAPER & CUP LOGO] and [HOT PAPER & FIRE LOGO] are trademarks of Clarivate Analytics, and/or its affiliated company or companies, and used herein by permission and/or license.