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Role of DNA repair and effect of herbal extract on LOH induced by ion beam radiations in ${it Saccharomyces cerevisiae}$

Nunoshiba, Tatsuo*; Yamauchi, Ayako*; Iwata, Rika*; Sato, Katsuya; Ono, Yutaka; Narumi, Issey*

The LOH (loss of heterozygosity) induction by various ion beam radiations was investigated in diploid ${it Saccharomyces cerevisiae}$. The ion beams $$^{12}$$C$$^{5+}$$, $$^{12}$$C$$^{6+}$$, $$^{4}$$He$$^{2+}$$ and $$^{40}$$Ar$$^{13+}$$ at the lowest dose of 37.5 Gy, which had $$sim$$10% lethality, induced LOH with $$sim$$5$-fold higher frequency, with dose-dependent manner until 150 Gy. The LOH induction was predominantly ($sim$$90%) resulted from homologous recombination. Pol$$zeta$$ may be involved in the induction of LOH by ion beam radiations, because in the strain lacking Rev3, only slight induction of LOH was observed, whereas no remarkable effect of deletion for Pol$$zeta$$ was observed on ion beam induced LOH. In addition, the effects of ${it Eucalyptus regnans}$ extracts were examined on iron-beam radiation induced LOH, and ethanol extract of ${it Eucalyptus regnans}$ possessed inhibitory effect on LOH induced by $$^{12}$$C$$^{6+}$$, $$^{4}$$He$$^{2+}$$ and $$^{40}$$Ar$$^{13+}$$ion-beam radiation.

Language

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English

Journal

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JAEA-Review 2014-050, JAEA Takasaki Annual Report 2013

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Number

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Pages

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P. 124

Publication Year/Month

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2015/03

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Patent information

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PDF

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Paper URL

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https://jopss.jaea.go.jp/pdfdata/JAEA-Review-2014-050.pdf#page=156

DOI for research data

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Keywords

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出芽酵母; DNA修復; へテロ接合生喪失

Research Facility

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TIARA(イオン照射研究施設)

Press Release

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Article of JAEA R&D Review

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Cooperating Institute

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国際基督教大学

Accesses

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- Accesses

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