On the dynamical approach of quantitative radiation biology

Ouchi, Noriyuki

Quantitative approach in radiation biology based on the clonogenic method and obtained cell survival curves as a dose-response relationship, are introduced. Generally, cell survival curves seem to have a universality on its function, i.e. functional form of survival curve seems to be unchanged under various conditions including different species. Various factors affecting the radiosensitivity have been introduced to find macroscopic nature of living organisms. Many mathematical models describing cell survival curves have been presented, however, functional form of cell survival curves derived from, based on biological mechanism does not yet exist. Finally, the possibility that the structural change of chromosome affects the repair process is discussed.