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Report No.

Responses of the salt chemotaxis learning in wild type and mutant ${it C. elegans}$ to microbeam irradiation

Sakashita, Tetsuya; Suzuki, Michiyo; Hattori, Yuya; Ikeda, Hiroko; Muto, Yasuko*; Yokota, Yuichiro; Funayama, Tomoo; Hamada, Nobuyuki*; Shirai, Kana*; Kobayashi, Yasuhiko

We applied the microbeam irradiation of the central nervous tissue in ${it C. elegans}$ to analyze direct radiation effects at a tissue level. Also, to investigate the mechanism of modulatory effects of irradiation on the salt chemotaxis learnign (SCL), we used two ${it C. elegans}$ mutants (${it gpc-1}$ and ${it daf-2}$) related to the SCL. Well-fed adults of wild-type and mutant ${it C. elegans}$ were irradiated with 12,000 carbon ion particles corresponding to 500 Gy at micro-aperture area. Immediately after microbeam irradiation, the SCL performance was examined based on the chemotaxis index (CI). CI during the SCL was decreased in the wild-type and ${it gpc-1}$ mutant animals, but microbeam irradiation did not significantly affect CIs of ${it daf-2}$ mutants. The difference of the SCL between ${it gpc-1}$ and ${it daf-2}$ mutants will be discussed at the meeting.



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