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Report No.

3D analysis by whole body serial sections of the systemic responses induced by local carbon-ion irradiation in medaka (${it Oryzias latipes}$)

Asaka, Tomomi*; Hashimoto, Chika*; Ito, Kazusa*; Yasuda, Takako*; Nagata, Kento*; Nishimaki, Toshiyuki*; Katsumura, Takafumi*; Ota, Hiroki*; Suzuki, Michiyo; Funayama, Tomoo; Kobayashi, Yasuhiko; Oda, Shoji*; Mitani, Hiroshi*

It is thought that the irradiation to the particular area of the individual could induce the irradiation impact to the outside of the irradiated area in addition to the irradiated region. In this study, we established the procedures to conduct carbon ion irradiation on adult Medaka, which can irradiate only either dorsal or ventral side of the fish, using the broad-beam irradiation system of JAEA-Takasaki. The irradiated fish were examined heart rate before the fixation. Thereafter, the systemic alteration was evaluated by serial cross sections of the whole body of the fish. Tissues at the irradiated side were seriously injured that corresponded to the range of the beam. However, secondary gill lamella showed the characteristic edema in either the ventral or dorsal irradiated fish unless the gill located at ventral, suggesting the systemic irradiation effect. There was no alteration in the heart rate after the irradiation suggesting no severe effects in blood flow in this condition.



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