Ionizing radiation and oxidative stress suppress locomotion and pharyngeal pumping motion in

放射線と酸化ストレスが線虫の這行運動と咽頭ポンピング運動を抑制する

鈴木 芳代; 坂下 哲哉; 服部 佑哉; 小林 泰彦

Suzuki, Michiyo; Sakashita, Tetsuya; Hattori, Yuya; Kobayashi, Yasuhiko

Oxidative stress such as hydrogen peroxide (HO) has been identified as one of the important factors in aging, and this may be related to the decrease in motility observed during the aging process. In the present study, we therefore explored the potential effectiveness of HO in the suppression of ' locomotion (crawling). Young adult wild-type animals were exposed to S-basal buffer containing graded doses of HO. Exposure to HO induced reduction of locomotion similar to that observed after whole-body irradiation. To investigate the radiation effects and the involvement of oxidative stress on other types of movement, we subsequently focused on the pharyngeal pumping motion (chewing and swallowing). The proportion of animals in which the pumping motion has stopped immediately after HO exposure increased. This response was similar to that of irradiated animals. These results support the possibility that radiation-induced suppression of both locomotion and pumping motion in was caused by radiation-produced HO. In this presentation, we will give an outline of the radiation effects on and discuss the involvement of the radiation-induced oxidative stress in the phenomena.