Production and purification of medical radioisotope Y-90 with accelerator neutrons by deuterons

Tsukada, Kazuaki  ; Sato, Tetsuya   ; Hashimoto, Kazuyuki; Saeki, Hideya; Hatsukawa, Yuichi; Nagai, Yasuki; Watanabe, Satoshi; Ishioka, Noriko; Takeda, Shinsaku*

A new system has been proposed for the generation of radioisotopes with accelerator neutrons by deuterons, especially the production of Y (T = 64 h), which has been used for the nuclear medicine. Enriched Zr nitrate samples were irradiated with neutrons, which were obtained by the C(d,n) using 40 MeV deuterons provided from the TIARA cyclotron. Y was successfully produced via the (n, p) reaction, and separated from the Zr nitrate target by three columns method with a hydrochloric acid. After the purification, a labelling of DTPA with Y had been performed. In this result, the yield was about 90% under 2.5 M of DTPA, although the yields were decreased at the DTPA concentration below 2.5 M.