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Report No.

Production and purification of medical radioisotope Y-90 with accelerator neutrons by deuterons

Tsukada, Kazuaki ; Sato, Tetsuya  ; Hashimoto, Kazuyuki; Saeki, Hideya; Hatsukawa, Yuichi; Nagai, Yasuki; Watanabe, Satoshi; Ishioka, Noriko; Takeda, Shinsaku*

A new system has been proposed for the generation of radioisotopes with accelerator neutrons by deuterons, especially the production of $$^{90}$$Y (T$$_{1/2}$$ = 64 h), which has been used for the nuclear medicine. Enriched $$^{90}$$Zr nitrate samples were irradiated with neutrons, which were obtained by the $$^{nat}$$C(d,n) using 40 MeV deuterons provided from the TIARA cyclotron. $$^{90}$$Y was successfully produced via the (n, p) reaction, and separated from the Zr nitrate target by three columns method with a hydrochloric acid. After the purification, a labelling of DTPA with $$^{90}$$Y had been performed. In this result, the yield was about 90% under $$>$$2.5 $$mu$$M of DTPA, although the yields were decreased at the DTPA concentration below 2.5 $$mu$$M.



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