Production of alpha-emitting radioisotopes using the cyclotron facilities at Osaka University and JAEA Takasaki, and the Tandem accelerator at Tokai, JAEA

Washiyama, Koshin*; Amano, Ryohei*; Maeda, Eita*; Yokoyama, Akihiko*; Nishinaka, Ichiro; Takahashi, Naruto*; Shinohara, Atsushi*; Watanabe, Shigeki; Ishioka, Noriko

In order to use of an alpha emitter for targeted alpha therapy, we have started the production and the utilization of At using 30 MeV He particle in the Bi(He, 2n)At nuclear reaction at cyclotron facilities of Osaka University and JAEA Takasaki. In addition to that, we have been developing a Rn/At generator to expand the availability of At to wide range of populations far away from cyclotron facilities. The results of studies on the At-chemistry for clinical use and on the development of the Rn/At generator will be presented. And a review of current status of targeted alpha therapy in Japan will be also introduced.