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Report No.

Production of alpha-emitting radioisotopes using the cyclotron facilities at Osaka University and JAEA Takasaki, and the Tandem accelerator at Tokai, JAEA

Washiyama, Koshin*; Amano, Ryohei*; Maeda, Eita*; Yokoyama, Akihiko*; Nishinaka, Ichiro; Takahashi, Naruto*; Shinohara, Atsushi*; Watanabe, Shigeki; Ishioka, Noriko

In order to use of an alpha emitter for targeted alpha therapy, we have started the production and the utilization of $$^{211}$$At using 30 MeV $$^4$$He particle in the $$^{209}$$Bi($$^4$$He, 2n)$$^{211}$$At nuclear reaction at cyclotron facilities of Osaka University and JAEA Takasaki. In addition to that, we have been developing a $$^{211}$$Rn/$$^{211}$$At generator to expand the availability of $$^{211}$$At to wide range of populations far away from cyclotron facilities. The results of studies on the At-chemistry for clinical use and on the development of the $$^{211}$$Rn/$$^{211}$$At generator will be presented. And a review of current status of targeted alpha therapy in Japan will be also introduced.



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