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Report No.

R&D on separation, concentration and recovery of $$^{99m}$$Tc from $$^{99}$$Mo for commercial production

Shiina, Takayuki*; Tsuchiya, Kunihiko ; Nagai, Yasuki; Morikawa, Yasumasa*; Takeuchi, Nobuhiro*

According to statistical data reported by the Japan Radioisotope Association (JRIA) in 2014, the $$^{99}$$Mo/$$^{99m}$$Tc generator and $$^{99m}$$Tc injections ($$^{99m}$$Tc labeled pharmaceuticals) continues to account for approximately 80% of the entire in-vivo supply in Japan. Furthermore, the number of $$^{99m}$$Tc injection supplies is approximately four times larger than that of the $$^{99}$$Mo/$$^{99m}$$Tc generator. Therefore, Chiyoda Technol Co. have performed a research and development (R&D) for the domestic production of $$^{99m}$$Tc in cooperation with the Japan Atomic Energy Agency (JAEA) and FUJIFILM RI pharma Co., Ltd. to ensure a constant and reliable supply of $$^{99m}$$Tc. CTC therefore has a plan to stably produce $$^{99m}$$Tc from $$^{99}$$Mo, which can be produced by the $$^{98}$$Mo(n,$$gamma$$) reaction using the Japan Materials Testing Reactor (JMTR) and by the $$^{100}$$Mo(n,2n) reaction using some new cyclotrons, and thereby to meet the Japanese demand for $$^{99m}$$Tc together with pharmaceutical companies in Japan. These production methods of $$^{99}$$Mo were selected from viewpoints of safety, nuclear proliferation resistance and waste management. The specific activity of $$^{99}$$Mo produced by these methods, however, is very low compared with that of (n,f)$$^{99}$$Mo. Therefore, it is essential to develop some techniques for separation, concentration and recovery of $$^{99m}$$Tc, and it will be necessary to choose the best methods such as a wet method by solvent extraction and a dry method by sublimation, finally. In future, we aim to provide to about 20% of the domestic demand for $$^{99}$$Mo using the JMTR and cyclotrons, 100-200 6-day Ci per week at the end of irradiation, and will carry out empirical studies for the commercial production of $$^{99m}$$Tc.



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