Studying signal-amplified chemiluminescence sensor for detecting infinitesimal nuclide

Hisamatsu, Shugo; Suzuki, Shinichi; Yaita, Tsuyoshi

A novel sensory system incorporated with an amplification function was devised for detection of trace-level substances. This sensory system comprises three steps, namely, recognition, amplification, and chemiluminescence. These steps were linked with chemical reactions and were induced continuously. The process from amplification to chemiluminescence was accomplished in the system using fluoride ions. The amplification was based on a self-immolative system, which permitted detection of the emission even at low concentration of fluoride ions for the system wherein chemiluminescence cannot be induced in the absence of fluoride ions. A suitable ratio of the chemiluminescent compound and the amplifier was optimized for efficient amplification.