Refine your search�ソスF     
Report No.

Rational evaluation of the therapeutic effect and dosimetry of auger electrons for radionuclide therapy in a cell culture model

Shinohara, Ayaka*; Hanaoka, Hirofumi*; Sakashita, Tetsuya*; Sato, Tatsuhiko   ; Yamaguchi, Aiko*; Ishioka, Noriko*; Tsushima, Yoshito*

Radionuclide therapy with low-energy auger electron emitters could potentially provide high anti-tumor efficacy while keeping normal organs toxicity low. In this study, we evaluated the usefulness of auger electron emitter $$^{125}$$I and compared it with beta-emitter $$^{131}$$I for tumor treatment in 2D and 3D cell culture models. The computer simulation model for 2D and 3D cell culture were constructed, and the absorbed radiation dose of $$^{125}$$I or $$^{131}$$I in each model were calculated by using a Monte Carlo simulation code (PHITS). The therapeutic effect of $$^{125}$$I was comparable to that of $$^{131}$$I in 2D model, but the efficacy was inferior to that of $$^{131}$$I-MIBG in 3D model, since crossfire effect is negligible and the homogeneous distribution of radionuclide was insufficient.



- Accesses




Category:Radiology, Nuclear Medicine & Medical Imaging



[CLARIVATE ANALYTICS], [WEB OF SCIENCE], [HIGHLY CITED PAPER & CUP LOGO] and [HOT PAPER & FIRE LOGO] are trademarks of Clarivate Analytics, and/or its affiliated company or companies, and used herein by permission and/or license.