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Report No.
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Modeling for clonogenicity of lens epithelial cells

Oikawa, Joma*; Matsuya, Yusuke  ; Hamada, Nobuyuki*; Date, Hiroyuki*

Risk of cataract after exposure has drawn an attention, however its onset mechanisms and the responses to low-dose exposure remain unclear. In recent years, it has been reported that human lens epithelial cells (HLEC1) induce excessive proliferation after exposure with more than 2 Gy, which might be related with cataract onset mechanism. In this study, to clarify the excessive proliferation in HLEC1, a cell colony model was developed by using agent-based model based on NetLogo. This model includes several parameters such as cell cycle, contact inhibition, upper limit of number of cell divisions to reproduce the experimental colony size of non-irradiated cells. From the model study, it was found that excessive proliferation after exposure can be reproduced by considering shortening the cell cycle and increasing the upper limit of cell division. These findings contribute to effective estimation for excessive proliferation of lens epithelial cells and cataract risk after exposure.

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