Refine your search�ソスF     
Report No.
 - 

Track structure study for energy dependency of electrons and X-rays on DNA double-strand break induction

Yachi, Yoshie*; Yoshii, Yuji*; Matsuya, Yusuke  ; Mori, Ryosuke*; Oikawa, Joma*; Date, Hiroyuki*

Radiation weighting factor for photon and electron is defined as 1.0 independently these energies. However, it should be noted that the biological effects after 29 kVp X-rays is relative higher than standard 200 kVp X-rays at the endpoint of ${it in vitro}$. And it is of importance to evaluate electrons generated via interaction of photons with matter. Here, we evaluated the energy concentration along electron track (dose-mean lineal energy) on chromosome (micron-meter) scales by Monte Carlo simulation, and measured the DNA double-strand breaks (DSBs) induction. From the cell experiments, the DSBs induction after diagnostic X-rays exposure (60-100 kVp) is higher than those with therapeutic X-rays (6 MV). In the relation between the dose-mean lineal energy and the number of DSBs, it was shown that lower energy photons might induce more biological impact due to the interaction by low energy electron. This study implies that radiation weighting factor for photon and electron should not be unity.

Accesses

:

- Accesses

InCites™

:

Percentile:32.42

Category:Multidisciplinary Sciences

Altmetrics

:

[CLARIVATE ANALYTICS], [WEB OF SCIENCE], [HIGHLY CITED PAPER & CUP LOGO] and [HOT PAPER & FIRE LOGO] are trademarks of Clarivate Analytics, and/or its affiliated company or companies, and used herein by permission and/or license.