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Development of a new microdosimetric biological weighting function for the RBE$$_{10}$$ assessment in case of the V79 cell line exposed to ions from $$^{1}$$H to $$^{238}$$U

Parisi, A.*; Sato, Tatsuhiko  ; Matsuya, Yusuke ; Kase, Yuki*; Magrin, G.*; Verona, C.*; Tran, L.*; Rosenfeld, A.*; Bianchi, A.*; Olko, P.*; Struelens, L.*; Vanhavere, F.*

A new biological weighting function (IBWF) is proposed to phenomenologically relate microdosimetric lineal energy probability density distributions with the relative biological effectiveness (RBE) for the in vitro clonogenic cell survival (survival fraction = 10%) of the most commonly used mammalian cell line, i.e. the Chinese hamster lung fibroblasts (V79). The RBE values assessed by the IBWF were found to be consistent and in good agreement with the ones calculated in combination with computer-simulated microdosimetric spectra, with an average relative deviation of 0.8% and 5.7% for H and C ions respectively.

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Category:Engineering, Biomedical

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