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Evaluation of the redox state in mouse organs following radon inhalation

Kataoka, Takahiro*; Kanzaki, Norie  ; Sakoda, Akihiro  ; Shuto, Hina*; Yano, Junki*; Naoe, Shota*; Tanaka, Hiroshi ; Hanamoto, Katsumi*; Terato, Hiroaki*; Mitsunobu, Fumihiro*; Yamaoka, Kiyonori*

Radon inhalation activates antioxidative functions in mouse organs, thereby contributing to inhibition of oxidative stress-induced damage. Therefore, in this study, we evaluated the redox state of various organs in mice following radon inhalation. Mice inhaled radon at concentrations of 2 or 20 kBq/m$$^{3}$$ for 1, 3, or 10 days. The relationship between antioxidative function and oxidative stress was evaluated by principal component analysis (PCA) and correlation coefficient compared with control mice subjected to sham inhalation. These findings suggested that radon inhalation altered the redox state in organs, but that the characteristics varied depending on the redox state in organs.

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