Changes in sulfur metabolism in mouse brains following radon inhalation

Kanzaki, Norie   ; Sakoda, Akihiro   ; Kataoka, Takahiro*; Sun, L.*; Tanaka, Hiroshi ; Otsu, Iwao*; Yamaoka, Kiyonori*

Reactive sulfur species (RSS) involve oxidative stress deeply and contribute anti-inflammatory effect, but no studied have focused on RSS changes after irradiation. In this study, we comprehensively analyzed the metabolites, focusing on RSS in mouse brain following radon inhalation. The ratio of oxidized glutathione to reduced glutathione and proportion of RSS in GSH or cysteine increased by radon inhalation. The sulfur ion might bind to GSH or cysteine chemically under conditions of oxidative stress, even at very low-dose exposure. We performed the overall assessment of high-dimensional data by applying machine learning and showed the specific characteristics of the effects by the exposure conditions. Our results suggested that RSS could produce a biological defense against oxidative stress following radon inhalation.