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Features of accelerator-based neutron source for boron neutron capture therapy calculated by Particle and Heavy Ion Transport code System (PHITS)

Matsuya, Yusuke  ; Kusumoto, Tamon*; Yachi, Yoshie*; Hirata, Yuho   ; Miwa, Misako*; Ishikawa, Masayori*; Date, Hiroyuki*; Iwamoto, Yosuke   ; Matsuyama, Shigeo*; Fukunaga, Hisanori*

Boron Neutron Capture Therapy (BNCT) is a radiation therapy, which can selectively eradicate solid tumors by $$alpha$$-particles and Li ions generated through the nuclear reaction between thermal neutron and $$^{10}$$B in tumor cells. With the development of accelerator-based neutron sources that can be installed in medical institutions, accelerator-based boron neutron capture therapy is expected to become available at several medical institutes around the world in the near future. Lithium is one of the targets that can produce thermal neutrons from the $$^{7}$$Li(p,n)$$^{7}$$Be near-threshold reaction. Particle and Heavy Ion Transport code System (PHITS) is a general-purpose Monte Carlo code, which can simulate a variety of diverse particle types and nuclear reactions. The latest PHITS code enables simulating the generation of neutrons from the $$^{7}$$Li(p,n)$$^{7}$$Be reactions by using Japanese Evaluated Nuclear Data Library (JENDL-4.0/HE). In this study, we evaluated the neutron fluence using the PHITS code by comparing it to reference data. The subsequent neutron transport simulations were also performed to evaluate the boron trifluoride (BF$$_{3}$$) detector responses and the recoiled proton fluence detected by a CR-39 plastic detector. As a result, these comparative studies confirmed that the PHITS code can accurately simulate neutrons generated from an accelerator using a Li target. The PHITS code has a significant potential for contributing to more precise evaluating accelerator-based neutron fields and understandings of therapeutic effects of BNCT.

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Category:Nanoscience & Nanotechnology

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