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Impact of the Lorentz force on electron track structure and early DNA damage yields in magnetic resonance-guided radiotherapy

Yachi, Yoshie*; Kai, Takeshi   ; Matsuya, Yusuke  ; Hirata, Yuho   ; Yoshii, Yuji*; Date, Hiroyuki*

Recently, magnetic resonance-guided radiotherapy (MRgRT) which can visualize tumors in real time has been developed and installed in several clinical facilities. It is known that Lorentz force modulate macroscopic dose distribution by a charged particle, however, the impact by the force on microscopic radiation-track structure and early DNA damage induction remain unclear. In this study, we simulated the electron-track structure in a static magnetic field using a PHITS, and estimated features of biological effects. We indicated that the macroscopic dose distributions are changed by the force, while early DNA damage such as double strand breaks is attributed to the secondary electrons below a few tens of eV which are independent of the force. We expect that our insight significantly contributes to the MRgRT.

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Category:Multidisciplinary Sciences

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