At]NaAt and [
I]NaI in an NIS-expressing thyroid cancer mouse modelWatabe, Tadashi*; Liu, Y.*; Kaneda, Kazuko*; Sato, Tatsuhiko 
; Shirakami, Yoshifumi*; Oe, Kazuhiro*; Toyoshima, Atsushi*; Shimosegawa, Eku*; Wang, Y.*; Haba, Hiromitsu*; Nakano, Takashi*; Shinohara, Atsushi*; Hatazawa, Jun*
In this study, we compare the therapeutic effect between [At]NaAt and [I]NaI. In vitro analysis of double-stranded DNA break (DSB) and colony formation assay were performed using K1-NIS cells. [At]NaAt induced higher numbers of DSBs and had a reduced colony formation than [I]NaI. In K1-NIS mice, dose-dependent therapeutic effects were observed in both [At]NaAt and [I]NaI. The superior therapeutic effect of [At]NaAt suggests the promising clinical applicability of targeted alpha therapy using [At]NaAt in patients with differentiated thyroid cancer refractory to standard [I]NaI treatment.
Language |
: | English |
|---|---|---|
Journal |
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Volume |
: | 23 |
Number |
: | 16 |
Pages |
: | p.9434_1 - 9434_11 |
Publication Year/Month |
: | 2022/08 |
Paper URL |
: |
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Keywords |
: | no keyword |
Accesses |
: |
- Accesses |
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InCites™ |
: |
Percentile:78.48 Category:Biochemistry & Molecular Biology |
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