Development of Linear Interpolation System for SMK Model parameters Evaluated from Cellular-scale simulation (LISMEC) and its application to BNCT dosimetry

Shigehira, Takafumi*; Watanabe, Tsubasa*; Suzuki, Minoru*; Hirata, Yuho   ; Ogawa, Tatsuhiko   ; Fujimura, Atsushi*; Sakurai, Yoshinori*; Sato, Tatsuhiko   

We developed LISMEC (Linear Interpolation System for Stochastic Microdosimetric Kinetic model parameters Evaluated from Cellular-scale simulation), a rapid estimation framework based on precomputed cellular-scale PHITS (Particle and Heavy Ion Transport code System) simulations covering various cell geometries and boron distributions. By applying a linear interpolation algorithm, LISMEC enables the retrieval of SMK model parameters without the need for computationally intensive cellular-scale simulations. The utility of LISMEC, in conjunction with PHITS, was demonstrated through simulations of various irradiation scenarios in reactor-based BNCT. The results showed that Diso E values ranged from 7.4 Gy to 32.7 Gy, even under a fixed macroscopic B concentration of 60 ppm. These findings emphasize the importance of incorporating microscopic distribution of B and cellular structures into BNCT treatment planning.