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Inter-institutional variability in kidney dosimetry during $$^{177}$$Lu-DOTATATE therapy in Japan

Miyaji, Noriaki*; Miwa, Kenta*; Sato, Tatsuhiko   ; 25 of others*

This study evaluated inter-institutional variability in kidney dosimetry using common $$^{177}$$Lu-SPECT/CT datasets from the SNMMI Dosimetry Challenge. Ten Japanese centers calculated kidney volumes and absorbed doses with various organ- and voxel-based software. Manual VOI contouring caused large variability (CV up to 16.9%), reduced to 7.4% using common VOIs. Voxel-based dosimetry yielded higher doses but reduced variability, highlighting the need for algorithm standardization to ensure reliable $$^{177}$$Lu-DOTATATE kidney dosimetry in Japan.

Language

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English

Journal

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Radiological Physics and Technology

Volume

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19

Number

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1

Pages

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p.165 - 175

Publication Year/Month

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2026/03

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Patent information

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Paper URL

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https://doi.org/10.1007/s12194-025-00993-0

DOI for research data

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Keywords

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no keyword

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Accesses

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- Accesses

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