Initialising ...
Initialising ...
Initialising ...
Initialising ...
Initialising ...
Initialising ...
Initialising ...
Tomita, Masanori*; Matsumoto, Hideki*; Funayama, Tomoo; Yokota, Yuichiro; Otsuka, Kensuke*; Maeda, Munetoshi*; Kobayashi, Yasuhiko
Life Sciences in Space Research, 6, p.36 - 43, 2015/07
A radiation-induced bystander response is generally known as a cellular response induced in unirradiated cell by receiving bystander signaling factors released from directly irradiated cells of a cell population. Bystander responses induced by high-LET heavy ions at low fluence are an important problem concerning the health of astronauts in the space environment. Here we set out NO-mediated bystander signal transductions induced by high-LET heavy-ion microbeam irradiation in normal human fibroblasts. Our findings suggest that Akt- and NF-
B-dependent signaling pathway involving COX-2 plays an important role in the NO-mediated high-LET heavy-ion-induced bystander responses. Additionally, COX-2 may be used as a molecular marker of high-LET heavy-ion-induced bystander cells, which are distinguish form directly irradiated cells.
Tomita, Masanori*; Matsumoto, Hideki*; Otsuka, Kensuke*; Funayama, Tomoo; Yokota, Yuichiro; Suzuki, Michiyo; Sakashita, Tetsuya; Kobayashi, Yasuhiko
JAEA-Review 2014-050, JAEA Takasaki Annual Report 2013, P. 77, 2015/03
Radiation-induced bystander responses are defined as responses in cells that have not been directly targeted by radiation but are in the neighborhood of cells that have been directly exposed. In this study, we aim to clarify a role of bystander response to sustain the homeostasis of damaged tissue using heavy-ion microbeams. We established the heavy-ion microbeam irradiation method to a 3D cultured human epidermis. Using this method, a viable cell rate of the 3D cultured human epidermis irradiated with 260 MeV 
Ne-ion microbeams or broadbeams was analyzed by the MTT method.
Matsumoto, Hideki*; Tomita, Masanori*; Otsuka, Kensuke*; Hatashita, Masanori*; Maeda, Munetoshi*; Funayama, Tomoo; Yokota, Yuichiro; Suzuki, Michiyo; Sakashita, Tetsuya; Ikeda, Hiroko; et al.
JAEA-Review 2014-050, JAEA Takasaki Annual Report 2013, P. 76, 2015/03
The objective of this project is to elucidate molecular mechanisms for the induction of radioadaptive response through radiation-induced bystander responses induced by irradiation with heavy ion microbeams in JAEA. We found that the adaptive response was induced by Ar (520 MeV 
Ar
) microbeam-irradiation of a limited number of cells, followed by the broad beam-irradiation and that the adaptive response was almost completely suppressed by the addition of carboxy-PTIO, as a nitric oxide (NO) scavenger. In addition, we found several genes induced specifically and preferentially when radioadaptive response could be induced. We confirmed that 
expression was specifically induced only when radioadaptive response could be induced. Our findings strongly suggested that radioadaptive response can be induced by NO-mediated bystander responses evoked by irradiation with heavy ion microbeams.
Ishigami, Tsutomu; Kobayashi, Kensuke; Umemoto, Michitaka; Matsunaga, Takeshi
Reliability Engineering & System Safety, 86(1), p.61 - 74, 2004/10
Times Cited Count：3 Percentile：12.11(Engineering, Industrial)no abstracts in English
Umemoto, Michitaka; Ishigami, Tsutomu; Kobayashi, Kensuke
Chiiki Anzen Gakkai Rombunshu, 4, p.231 - 240, 2002/11
no abstracts in English
Matsunaga, Takeshi; Kobayashi, Kensuke
Hoken Butsuri, 36(1), p.31 - 44, 2001/03
no abstracts in English
Umemoto, Michitaka; Kobayashi, Kensuke; Ishigami, Tsutomu; Watanabe, Minoru*
Chiiki Anzen Gakkai Kogaishu, 10, p.113 - 116, 2000/11
On September 30 in 1999, the reactivity accident occurred at the Tokai uranium processifn facility of J. C. O. Co. Ltd(JCO) at Tokai-mura, Japan. Before the accident had been brought under control, the local authorities evacuated the population living within a few hundred meters and advised people within 10km of the facility to take shelter for a period of about one day. Questionnaires were conducted to know when, where and how the inhabitants received the information of protective action requests from the local authories and how they responded to the requests.
Matsunaga, Takeshi; Kobayashi, Kensuke
Proceedings of 10th International Congress of the International Radiation Protection Association (IRPA-10) (CD-ROM), 10 Pages, 2000/05
no abstracts in English
Ishigami, Tsutomu; Kobayashi, Kensuke
Journal of Nuclear Science and Technology, 35(6), p.443 - 453, 1998/06
Times Cited Count：1 Percentile：15.01(Nuclear Science & Technology)no abstracts in English
Ishigami, Tsutomu; Kobayashi, Kensuke
Hoken Butsuri, 33(1), p.57 - 66, 1998/00
no abstracts in English
Umemoto, Michitaka; ; Kobayashi, Kensuke; Ishigami, Tsutomu; ; ;
Chiiki Anzen Gakkai Rombun Hokokushu, (7), p.228 - 233, 1997/11
no abstracts in English
Ishigami, Tsutomu; Kobayashi, Kensuke;
Proc. of the 6th Topical Meeting on Emergency Preparedness and Response, 0, p.319 - 320, 1997/04
no abstracts in English
; Ishigami, Tsutomu; Kobayashi, Kensuke
29th Int. Symp. on Automotive Technology & Automation, 0, p.341 - 348, 1996/00
no abstracts in English
Ishigami, Tsutomu; ; Kobayashi, Kensuke
29th Int. Symp. on Automotive Technology & Automation, 0, p.349 - 356, 1996/00
no abstracts in English
Kobayashi, Kensuke; Ishigami, Tsutomu; ; ; ; ;
Genshiryoku Kogyo, 42(1), p.44 - 53, 1996/00
no abstracts in English
Kobayashi, Kensuke; Ishigami, Tsutomu; ; ;
Journal of Nuclear Science and Technology, 32(5), p.476 - 487, 1995/05
Times Cited Count：3 Percentile：36.70(Nuclear Science & Technology)no abstracts in English
; Ishigami, Tsutomu; ; Kobayashi, Kensuke
Proc., Dedicated Conf. on Mechatronics & Supercomputing Applications in the Transportation Industries, 0, p.865 - 871, 1994/00
no abstracts in English
Ishigami, Tsutomu; ; ; Kobayashi, Kensuke
Proc., Dedicated Conf. on Mechatronics & Supercomputing Applications in the Transportation Industries, 0, p.857 - 865, 1994/00
no abstracts in English
Ishigami, Tsutomu; Kobayashi, Kensuke
Nihon Genshiryoku Gakkai-Shi, 35(6), p.549 - 560, 1993/06
Times Cited Count：0 Percentile：0.01(Nuclear Science & Technology)no abstracts in English
Izumi, Fumio; ; Kobayashi, Kensuke;
JAERI-M 92-204, 532 Pages, 1993/01
no abstracts in English
