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Journal Articles

Nitric oxide-mediated bystander signal transduction induced by heavy-ion microbeam irradiation

Tomita, Masanori*; Matsumoto, Hideki*; Funayama, Tomoo; Yokota, Yuichiro; Otsuka, Kensuke*; Maeda, Munetoshi*; Kobayashi, Yasuhiko

Life Sciences in Space Research, 6, p.36 - 43, 2015/07

A radiation-induced bystander response is generally known as a cellular response induced in unirradiated cell by receiving bystander signaling factors released from directly irradiated cells of a cell population. Bystander responses induced by high-LET heavy ions at low fluence are an important problem concerning the health of astronauts in the space environment. Here we set out NO-mediated bystander signal transductions induced by high-LET heavy-ion microbeam irradiation in normal human fibroblasts. Our findings suggest that Akt- and NF-$$kappa$$B-dependent signaling pathway involving COX-2 plays an important role in the NO-mediated high-LET heavy-ion-induced bystander responses. Additionally, COX-2 may be used as a molecular marker of high-LET heavy-ion-induced bystander cells, which are distinguish form directly irradiated cells.

Journal Articles

Analysis of bystander response in 3D cultured tissue induced by heavy-ion microbeam irradiation

Tomita, Masanori*; Matsumoto, Hideki*; Otsuka, Kensuke*; Funayama, Tomoo; Yokota, Yuichiro; Suzuki, Michiyo; Sakashita, Tetsuya; Kobayashi, Yasuhiko

JAEA-Review 2014-050, JAEA Takasaki Annual Report 2013, P. 77, 2015/03

Radiation-induced bystander responses are defined as responses in cells that have not been directly targeted by radiation but are in the neighborhood of cells that have been directly exposed. In this study, we aim to clarify a role of bystander response to sustain the homeostasis of damaged tissue using heavy-ion microbeams. We established the heavy-ion microbeam irradiation method to a 3D cultured human epidermis. Using this method, a viable cell rate of the 3D cultured human epidermis irradiated with 260 MeV $$^{20}$$Ne-ion microbeams or broadbeams was analyzed by the MTT method.

Journal Articles

Mechanisms for the induction of radioadaptive response by radiation-induced bystander response

Matsumoto, Hideki*; Tomita, Masanori*; Otsuka, Kensuke*; Hatashita, Masanori*; Maeda, Munetoshi*; Funayama, Tomoo; Yokota, Yuichiro; Suzuki, Michiyo; Sakashita, Tetsuya; Ikeda, Hiroko; et al.

JAEA-Review 2014-050, JAEA Takasaki Annual Report 2013, P. 76, 2015/03

The objective of this project is to elucidate molecular mechanisms for the induction of radioadaptive response through radiation-induced bystander responses induced by irradiation with heavy ion microbeams in JAEA. We found that the adaptive response was induced by Ar (520 MeV $$^{40}$$Ar$$^{14+}$$) microbeam-irradiation of a limited number of cells, followed by the broad beam-irradiation and that the adaptive response was almost completely suppressed by the addition of carboxy-PTIO, as a nitric oxide (NO) scavenger. In addition, we found several genes induced specifically and preferentially when radioadaptive response could be induced. We confirmed that ${it iNOS}$ expression was specifically induced only when radioadaptive response could be induced. Our findings strongly suggested that radioadaptive response can be induced by NO-mediated bystander responses evoked by irradiation with heavy ion microbeams.

Journal Articles

A Simplified simulation method for selecting the most effective off-site protective action

Ishigami, Tsutomu; Kobayashi, Kensuke; Umemoto, Michitaka; Matsunaga, Takeshi

Reliability Engineering & System Safety, 86(1), p.61 - 74, 2004/10

 Times Cited Count:3 Percentile:12.11(Engineering, Industrial)

no abstracts in English

Journal Articles

The Inhabitants' reaction after contact with disaster information at the JCO criticality accident

Umemoto, Michitaka; Ishigami, Tsutomu; Kobayashi, Kensuke

Chiiki Anzen Gakkai Rombunshu, 4, p.231 - 240, 2002/11

no abstracts in English

Journal Articles

Sensitivity analysis on the deposition of inhaled radioactive iodine and the effectiveness of iodine prophylaxis

Matsunaga, Takeshi; Kobayashi, Kensuke

Hoken Butsuri, 36(1), p.31 - 44, 2001/03

no abstracts in English

Journal Articles

The Inhabitants' receiving disaster information and their reaction at the JCO criticality accident in Tokai-mura

Umemoto, Michitaka; Kobayashi, Kensuke; Ishigami, Tsutomu; Watanabe, Minoru*

Chiiki Anzen Gakkai Kogaishu, 10, p.113 - 116, 2000/11

On September 30 in 1999, the reactivity accident occurred at the Tokai uranium processifn facility of J. C. O. Co. Ltd(JCO) at Tokai-mura, Japan. Before the accident had been brought under control, the local authorities evacuated the population living within a few hundred meters and advised people within 10km of the facility to take shelter for a period of about one day. Questionnaires were conducted to know when, where and how the inhabitants received the information of protective action requests from the local authories and how they responded to the requests.

Journal Articles

Sensitivity analysis on the effectiveness of iodine prophylaxis to reduce thyroid gland exposure in nuclear emergency

Matsunaga, Takeshi; Kobayashi, Kensuke

Proceedings of 10th International Congress of the International Radiation Protection Association (IRPA-10) (CD-ROM), 10 Pages, 2000/05

no abstracts in English

Journal Articles

A Real-time prediction technique of severe accident progression in containment for emergency response

Ishigami, Tsutomu; Kobayashi, Kensuke

Journal of Nuclear Science and Technology, 35(6), p.443 - 453, 1998/06

 Times Cited Count:1 Percentile:15.01(Nuclear Science & Technology)

no abstracts in English

Journal Articles

Current status of research on emergency response measures at JAERI

Ishigami, Tsutomu; Kobayashi, Kensuke

Hoken Butsuri, 33(1), p.57 - 66, 1998/00

no abstracts in English

Journal Articles

Transmission of evacuation recommendation during a LPG leak incident at Higashinada ward, Kobe city in the Great Hanshin-Awaji Earthquake Disaster

Umemoto, Michitaka; ; Kobayashi, Kensuke; Ishigami, Tsutomu; ; ;

Chiiki Anzen Gakkai Rombun Hokokushu, (7), p.228 - 233, 1997/11

no abstracts in English

Journal Articles

Development of evacuation simulation system

Ishigami, Tsutomu; Kobayashi, Kensuke;

Proc. of the 6th Topical Meeting on Emergency Preparedness and Response, 0, p.319 - 320, 1997/04

no abstracts in English

Journal Articles

Application of TRAF-NETSIM to evacuation simulation in an emergency

; Ishigami, Tsutomu; Kobayashi, Kensuke

29th Int. Symp. on Automotive Technology & Automation, 0, p.341 - 348, 1996/00

no abstracts in English

Journal Articles

Transportation evacuation simulation with STREEM

Ishigami, Tsutomu; ; Kobayashi, Kensuke

29th Int. Symp. on Automotive Technology & Automation, 0, p.349 - 356, 1996/00

no abstracts in English

Journal Articles

A Computerized support system for the emergency technical advisory body in Japan

Kobayashi, Kensuke; Ishigami, Tsutomu; ; ; ; ;

Genshiryoku Kogyo, 42(1), p.44 - 53, 1996/00

no abstracts in English

Journal Articles

COSTA: A Computerized support system for emergency technical advisory body in Japan

Kobayashi, Kensuke; Ishigami, Tsutomu; ; ;

Journal of Nuclear Science and Technology, 32(5), p.476 - 487, 1995/05

 Times Cited Count:3 Percentile:36.70(Nuclear Science & Technology)

no abstracts in English

Journal Articles

Comparative study of transportation evacuation simulation in emergency with STREEM and NETSIM

; Ishigami, Tsutomu; ; Kobayashi, Kensuke

Proc., Dedicated Conf. on Mechatronics & Supercomputing Applications in the Transportation Industries, 0, p.865 - 871, 1994/00

no abstracts in English

Journal Articles

Development of a computer program STREEM for simulating transportation evacuation in emergency

Ishigami, Tsutomu; ; ; Kobayashi, Kensuke

Proc., Dedicated Conf. on Mechatronics & Supercomputing Applications in the Transportation Industries, 0, p.857 - 865, 1994/00

no abstracts in English

Journal Articles

Analysis of accident management in steam generator tube rupture event

Ishigami, Tsutomu; Kobayashi, Kensuke

Nihon Genshiryoku Gakkai-Shi, 35(6), p.549 - 560, 1993/06

 Times Cited Count:0 Percentile:0.01(Nuclear Science & Technology)

no abstracts in English

JAEA Reports

Data list of nuclear power plants in Japan; PWR edition, 1992

Izumi, Fumio; ; Kobayashi, Kensuke;

JAERI-M 92-204, 532 Pages, 1993/01

JAERI-M-92-204.pdf:15.06MB

no abstracts in English

60 (Records 1-20 displayed on this page)