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Journal Articles

Labeling of bifunctional chelating agent, MAG3, with carrier-free $$^{188}$$Re

Hashimoto, Kazuyuki; Wan, K. W. H. B. B.*; Matsuoka, Hiromitsu

Journal of Nuclear and Radiochemical Sciences, 6(3), p.193 - 196, 2005/12

https://doi.org/10.14494/jnrs2000.6.3_193

The radioisotopes of rhenium ($$^{186}$$Re and $$^{188}$$Re) are attractive radionuclides for radiotherapy because of their energetic beta particles and gamma rays suitable for imaging. Mercaptoacetyltriglycine, MAG3 (N$$_{3}$$S ligand), is a useful bifunctional ligand in labeling monoclonal antibodies with metallic radionuclides. In this study, the labeling of MAG3 with carrier-free $$^{188}$$Re from a $$^{188}$$W/$$^{188}$$Re generator was investigated in detail. The $$^{188}$$Re-MAG3 complex was synthesized by the direct labeling method and by the indirect labeling method using a transfer ligand (citric acid or gluconic acid). The dependence of the labeling yield upon the reaction conditions such as the concentrations of tin(II) chloride dihydrate as a reducing agent, S-benzoyl MAG3 and the transfer ligand, pH, temperature, reaction time and the addition of a carrier was examined. The labeling yield of $$^{188}$$Re-MAG3 synthesized by the all method was over 90% under the optimum conditions.

Journal Articles

Application of PZC to $$^{188}$$W/$$^{188}$$Re generators

Matsuoka, Hiromitsu; Hashimoto, Kazuyuki; Hishinuma, Yukio*; Ishikawa, Koji*; Terunuma, Hitoshi*; Tatenuma, Katsuyoshi*; Uchida, Shoji*

Journal of Nuclear and Radiochemical Sciences, 6(3), p.189 - 191, 2005/12

https://doi.org/10.14494/jnrs2000.6.3_189

Applicability of Mo adsorbent PZC(Poly Zirconium Compound) for $$^{188}$$W/$$^{188}$$Re generator was investigated. Long term stability of adsorption of $$^{188}$$W to the PZC column, elution of $$^{188}$$Re from PZC column, desorption of $$^{188W}$$ from PZC column, and labeling of Hydroxyethylidene Diphosphonic Acid(HEDP) and Mercaptoacetyltriglycine(MAG3) with $$^{188}$$Re eluted from PZC column were tested. The PZC generator gave reproducible $$^{188}$$Re elution yields with low $$^{188}$$W parent breakthrough for a long period of time(about 5 months), that is the $$^{188}$$W/$$^{188}$$Re generator using PZC has a potential for practical use.

Journal Articles

Analysis of $$^{188}$$Re-EDTMP complexes by HPLC and ultrafiltration

Hashimoto, Kazuyuki; Matsuoka, Hiromitsu

Radiochimica Acta, 92(4-6), p.285 - 290, 2004/07

https://doi.org/10.1524/ract.92.4.285.35587
 Times Cited Count：1 Percentile：9.92(Chemistry, Inorganic & Nuclear)

no abstracts in English

Journal Articles

Production of no-carrier-added $$^{177}$$Lu via the $$^{176}$$Yb(n,$$gamma$$)$$^{177}$$Yb$$rightarrow$$$$^{177}$$Lu process

Hashimoto, Kazuyuki; Matsuoka, Hiromitsu; Uchida, Shoji*

Journal of Radioanalytical and Nuclear Chemistry, 255(3), p.575 - 579, 2003/03

https://doi.org/10.1023/A:1022557121351
 Times Cited Count：42 Percentile：91.70(Chemistry, Analytical)

The $$beta^{-}$$ emitter $$^{177}$$Lu is a promising therapeutic radioisotope for the treatment of cancer. It has a half-life of 6.73 days and maximum $$beta^{-}$$ energy of 498 keV, resulting in a short range of radiation in tissue. The decay is accompanied by the emission of low energy $$gamma$$-radiation with $$E_{gamma}$$ = 208 keV (11.0%) and 113 keV (6.4%) suitable for simultaneous imaging. Lutetium-177 can be usually produced at nuclear reactors with high yield and high specific radioactivity by the $$^{176}$$Lu(n,$$gamma$$)$$^{177}$$Lu reaction. However, radioisotopes with higher specific radioactivity are required in the field of radioimmunotherapy using labeled monoclonal antibodies. Thus, an alternative production route, namely the $$^{176}$$Yb(n,$$gamma$$)$$^{177}$$Yb $$rightarrow$$ $$^{177}$$Lu process was studied to produce no-carrier-added (nca) $$^{177}$$Lu in this work. The radiochemical separation of the nca $$^{177}$$Lu from the macroscopic ytterbium target was investigated by means of reversed-phase ion-pair HPLC. The nca $$^{177}$$Lu was obtained in radiochemical pure form with a separation yield of 80%.

Journal Articles

Excitation functions of rhenium isotopes on the $$^{nat.}$$W(d,xn) reactions and production of no-carrier-added $$^{186}$$Re

Ishioka, Noriko; Watanabe, Satoshi; Osa, Akihiko; Koizumi, Mitsuo; Matsuoka, Hiromitsu; Sekine, Toshiaki

Journal of Nuclear Science and Technology, 39(Suppl.2), p.1334 - 1337, 2002/08

http://wwwndc.jaea.go.jp/nd2001/proc/pdf/2_1334.pdf

Experimental cross sections for the reactions $$^{186}$$W(d,2n)$$^{186}$$Re, $$^{nat.}$$W(d,xn)$$^{181-184}$$Re and $$^{186}$$W(d,p)$$^{187}$$W are measured up to 34 MeV using the stacked foil method. The values obtained are compared with cross sections calculated using the ALICE code. The experimental and theoretical excitation functions are in reasonable agreement except for the $$^{186}$$W(d,p)$$^{187}$$W reaction.

JAEA Reports

Production of $$^{139}$$Ce by the $$^{139}$$La(p,n)$$^{139}$$Ce reaction

Ishioka, Noriko; Izumo, Mishiroku; Hashimoto, Kazuyuki; Kobayashi, Katsutoshi; Matsuoka, Hiromitsu; Sekine, Toshiaki

JAERI-Tech 2001-095, 23 Pages, 2002/01

JAERI-Tech-2001-095.pdf:1.1MB

no abstracts in English

Journal Articles

Adsorption of $$^{188}$$Re complexes with aminomethylenephosphonate on hydroxyapatite

Hashimoto, Kazuyuki; Matsuoka, Hiromitsu; Izumo, Mishiroku

Journal of Nuclear and Radiochemical Sciences, 2(1-2), p.5 - 9, 2001/12

https://doi.org/10.14494/jnrs2000.2.5

The radioactive rhenium complexes with phosphonate-containing ligands are good bone seeking compounds, and have been developed for the palliative treatment of metastatic bone pain. In this paper, we describe the adsorption properties of newly developed $$^{188}$$Re complexes with aminomethylenephosphonate ($$^{188}$$Re-EDTMP, EDBMP and NTMP) on hydroxyapatite, which is the major constituent of the hard tissues of bone. The influence of the shaking time, pH and the ionic strength on the adsorption was investigated. The adsorption of $$^{188}$$Re complexes was strongly affected by pH and ionic strength in a solution. The adsorption coefficient increased with decreasing pH and ionic strength. These observations suggest that one of the causes of the adsorption of $$^{188}$$Re-amp is considered the electrostatic forces between the negative $$^188$$Re-amp complex and the positive HAP surface. The adsorption affinity of the $$^{188}$$Re-amp complex for HAP increased in the order $$^{188}$$Re-EDBMP$$<^{188}$$Re-NTMP$$<^{188}$$Re-EDTMP.

Journal Articles

Production of positron emitters and application of their labeled compounds to plant studies

Ishioka, Noriko; Matsuoka, Hiromitsu; Watanabe, Satoshi; Osa, Akihiko; Koizumi, Mitsuo; Matsuhashi, Shimpei; Kume, Tamikazu; Sekine, Toshiaki; Uchida, Hiroshi*; Tsuji, Atsunori*; et al.

Journal of Radioanalytical and Nuclear Chemistry, 239(2), p.417 - 421, 1999/00

https://doi.org/10.1007/BF02349523
 Times Cited Count：27 Percentile：86.09(Chemistry, Analytical)

no abstracts in English

Journal Articles

A New water target system for the production of $$^{18}$$F and $$^{13}$$N to be used in plant study

Ishioka, Noriko; Matsuoka, Hiromitsu; Watanabe, Satoshi; Osa, Akihiko; Koizumi, Mitsuo; Sekine, Toshiaki

Synthesis and Applications of Isotopically Labelled Compounds 1997, p.669 - 672, 1998/00

no abstracts in English

Journal Articles

Analysis of carbon translocation in plants using positron-emitting tracer

Kume, Tamikazu; Matsuhashi, Shimpei; Ito, Hitoshi; G.W.Roeb*; Ishioka, Noriko; Osa, Akihiko; Matsuoka, Hiromitsu; Sekine, Toshiaki; Uchida, Hiroshi*; Tsuji, Atsunori*; et al.

JAERI-Review 97-015, p.51 - 53, 1997/11

https://jopss.jaea.go.jp/pdfdata/JAERI-Review-97-015.pdf

no abstracts in English

Journal Articles

Uptake and transport of positron-emitting tracer ($$^{18}$$F) in plants

Kume, Tamikazu; Matsuhashi, Shimpei; ; Ito, Hitoshi; Fujimura, Takashi; ; Uchida, Hiroshi*; Ishioka, Noriko; Matsuoka, Hiromitsu; Osa, Akihiko; et al.

Applied Radiation and Isotopes, 48(8), p.1035 - 1043, 1997/00

https://doi.org/10.1016/S0969-8043(97)00117-6
 Times Cited Count：53 Percentile：94.98(Chemistry, Inorganic & Nuclear)

no abstracts in English

Journal Articles

Uptake and transport of positron-emitting tracer in irradiated plants

Kume, Tamikazu; Matsuhashi, Shimpei; ; Ito, Hitoshi; Uchida, Hiroshi*; Tsuji, Atsunori*; Ishioka, Noriko; Matsuoka, Hiromitsu; Osa, Akihiko; Sekine, Toshiaki

Plant Nutrition for Sustainable Food Production and Environment, 0, p.169 - 170, 1997/00

no abstracts in English

Journal Articles

Tantalum-183: Cyclotron production of a neutron-rich biomedical tracer

Ishioka, Noriko; Lambrecht, R. M.*; Matsuoka, Hiromitsu; Osa, Akihiko; Koizumi, Mitsuo; Kobayashi, Katsutoshi; Izumo, Mishiroku; Hashimoto, Kazuyuki; Sekine, Toshiaki

Applied Radiation and Isotopes, 47(2), p.171 - 174, 1996/00

https://doi.org/10.1016/0969-8043(95)00254-5
 Times Cited Count：4 Percentile：39.37(Chemistry, Inorganic & Nuclear)

no abstracts in English

Journal Articles

Production method of no-carrier-added $$^{186}$$Re

Ishioka, Noriko; Matsuoka, Hiromitsu; Osa, Akihiko; Koizumi, Mitsuo; Izumo, Mishiroku; Kobayashi, Katsutoshi; Hashimoto, Kazuyuki; Sekine, Toshiaki; Lambrecht, R. M.*

Journal of Radioanalytical and Nuclear Chemistry, 205(1), p.85 - 92, 1996/00

https://doi.org/10.1007/BF02040553
 Times Cited Count：46 Percentile：95.14(Chemistry, Analytical)

no abstracts in English

Journal Articles

Synthesis and biodistribution of rhenium-186-labeled HEDP

Shigeta, Noriko; Matsuoka, Hiromitsu; Sekine, Toshiaki; Osa, Akihiko; Koizumi, Mitsuo; ; ; ; ; Lambrecht, R. M.*

Dai-4-Kai TIARA Kenkyu Happyokai Yoshishu, p.70 - 71, 1995/06

no abstracts in English

Journal Articles

A New radioisotope-production research facility utilizing ion beams from AVF cyclotron

Sekine, Toshiaki; Izumo, Mishiroku; Matsuoka, Hiromitsu; Kobayashi, Katsutoshi; Ishioka, Noriko; Osa, Akihiko; Koizumi, Mitsuo; Motoishi, Shoji; Hashimoto, Kazuyuki; ; et al.

Proc. of the 5th Int. Workshop on Targetry and Target Chemistry, 0, p.347 - 352, 1994/00

no abstracts in English

Journal Articles

Design of a fast method to produce $$^{14}$$C-labeled carboxylic acids

G.Ferro-Flores*; ; Sakamoto, Fuminori; Matsuoka, Hiromitsu;

Journal of Radioanalytical and Nuclear Chemistry, Letters, 175(3), p.219 - 228, 1993/00

no abstracts in English

Journal Articles

Production of $$^{95m}$$Tc with proton bombardment of $$^{95}$$Mo

Izumo, Mishiroku; Matsuoka, Hiromitsu; Sorita, Takami; Nagame, Yuichiro; Sekine, Toshiaki; ;

Applied Radiation and Isotopes, 42(3), p.297 - 301, 1991/00

https://doi.org/10.1016/0883-2889(91)90092-F

no abstracts in English

JAEA Reports

Production of $$^{95m}$$Tc with the $$^{95}$$Mo(p,n) reaction

Izumo, Mishiroku; Sorita, Takami; Matsuoka, Hiromitsu; Nagame, Yuichiro; ; Sekine, Toshiaki;

JAERI-M 90-156, 13 Pages, 1990/09

JAERI-M-90-156.pdf:0.4MB

no abstracts in English

JAEA Reports

Production of $$^{237}$$Pu and $$^{236}$$Pu with $$^{237}$$Np targets

Izumo, Mishiroku; Sorita, Takami; ; Sekine, Toshiaki; Matsuoka, Hiromitsu; Motoki, Ryozo;

JAERI-M 90-102, 28 Pages, 1990/07

JAERI-M-90-102.pdf:0.85MB

no abstracts in English

27 (Records 1-20 displayed on this page)