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Matsumoto, Atsushi; Kamata, Tetsuji*; Takagi, Junichi*; Iwasaki, Kenji*; Yura, Kei
Biophysical Journal, 95(6), p.2895 - 2908, 2008/09
Times Cited Count:20 Percentile:44.45(Biophysics)Protein is activated, but the activation mechanism and generality of the conformational change remain to be elucidated. We performed normal mode analysis of the elastic network model on integrin 


ectodomain in the bent form and identified key residues which were influential on molecular motions. Iterative normal mode calculations demonstrated that the specific non-bonded interactions involving the key residues work as a snap to keep integrin in the bent form. The importance of the key residues for the conformational change was further verified by mutation experiments. Conservation pattern of amino acid residues among integrin family showed that the characteristic pattern of residues seen around these key residues is found in the limited groups of integrin
chains.
Yoshikawa, Hiroshi; Sakaki, Hironao; Sako, Hiroyuki; Takahashi, Hiroki; Shen, G.; Kato, Yuko; Ito, Yuichi; Ikeda, Hiroshi*; Ishiyama, Tatsuya*; Tsuchiya, Hitoshi*; et al.
Proceedings of International Conference on Accelerator and Large Experimental Physics Control Systems (ICALEPCS '07) (CD-ROM), p.62 - 64, 2007/10
J-PARC is a large scale facility of the proton accelerators for the multi-purpose of scientific researches in Japan. This facility consists of three accelerators and three experimental stations. Now, J-PARC is under construction, and LINAC is operated for one year, 3GeV synchrotron has just started the commissioning in this October the 1st. The completion of this facility will be next summer. The control system of accelerators established fundamental performance for the initial commissioning. The most important requirement to the control system of this facility is to minimize the activation of accelerator devices. In this paper, we show that the performances of each layer of this control system have been achieved in the initial stage.
; ; Wakai, Takashi; Aoto, Kazumi; Ueno, Fumiyoshi; Nagae, Yuji; Kato, Shoichi; Saito, Junichi
JNC TN9400 2003-034, 26 Pages, 2003/05
The structual material of the future Fast Breeder Reactors(FBRs) must be improved to achive some requirements for improvement of safety and economical competitiveness. To prepare the desired data for the structural material development for the future FBRs, some mechanical and chemical tests, i.e. high temterature tensile tests and sodium corrosion tests, of the high-purity Fe-Cr alloys were conducted under the FBR conditions. As a result, following conclusions are obtained; 1) By eliminating the trace elements, high Cr content iron based alloys can be produced. It was clarified that such alloys have good tensile properties and creep strength enough for practical use at elevated temperature. 2) Through the manufacturing of a full size structure using the high purity Fe-50% Cr alloy, it was confirmed that the alloy has good manufacturability enough for practical use."
; ; ; ; Aoto, Kazumi;
JNC TN9400 2000-059, 43 Pages, 2000/05
The purpose of this study is to understand the material properties of manufacturable high-purity iron and high-purity iron-based alloy in present technology and to get an applicable prospect for the structural and functional material of the frontier fast reactor. Then the about 10kg high-purity iron and iron-based alloy were melted using a cold-crucible induction melting furnace under the ultra-high vacuum. Subsequent to that, the compatibility between the melted material and the high-temperature sodium environment which is a special feature of the fast reactor and tensile property at room and elevated temperatures were investigated using the melted materials. Also, the creep test using the high-purity 50%Cr-Fe alloy at 550
C in air in order to understand the high temperature creep property. ln addition, the material properties such as thermal expansion coefficient, specific heat and electrical resistance were measured and to evaluate the outlook for the structural material for the fast reactor. The following results were obtained based on the property test and evaluation. (1)lt was possible to melt the about 10kg high-purity ingot and high-purity 50%Cr-Fe alloy ingot using a cold-crucible induction melting furnace under the ultra-high vacuum. (2)The tensile tests of the high-purity 50%Cr-Fe alloy were performed at room and elevated temperatures in order to understand the deformation behavior. From the experimental results, it was clear that the high-purity 50%Cr-Fe alloy possesses high strength and good ductility at elevated temperatures. (3)The physical properties (the thermal expansion coefficient and specific heat etc.) were measured using the high-purity 50%Cr-Fe alloy. lt was clear that the thermal expansion coefficient of high-purity 50%Cr-Fe alloy was smaller than that of SUS304. (4)From the corrosion test in liquid sodium, the ordinary-purity iron showed the weight loss after corrosion test. However the high-purity iron showed ...
Matsumoto, Atsushi; Takagi, Junichi*; Iwasaki, Kenji*
no journal, ,
Iwasaki, Kenji*; Takagi, Junichi*; Matsumoto, Atsushi
no journal, ,
no abstracts in English
Matsumoto, Atsushi; Takagi, Junichi*; Iwasaki, Kenji*
no journal, ,
Matsumoto, Atsushi; Takagi, Junichi*; Iwasaki, Kenji*
no journal, ,
Matsumoto, Atsushi; Takagi, Junichi*; Iwasaki, Kenji*
no journal, ,
Matsumoto, Atsushi; Takagi, Junichi*; Iwasaki, Kenji*
no journal, ,
no abstracts in English
Matsumoto, Atsushi; Takagi, Junichi*; Iwasaki, Kenji*
no journal, ,
Matsumoto, Atsushi; Kamata, Tetsuji*; Iwasaki, Kenji*; Takagi, Junichi*; Yura, Kei
no journal, ,
Integrin, a membrane protein with a huge extracellular domain, participates in cell-cell and cell-extracellular matrix interactions for metazoan. A group of integrins are known to perform a large-scale structural change when they are activated, but their mechanism and generality of the conformational change in other integrins remain to be elucidated. We performed normal mode analysis based on the elastic network models of integrin in the bent form to identify key residues dominating the molecular motions toward activation. We simulated the large conformational change of integrin from the bent to the extended forms by iterative normal mode calculations and demonstrated that specific non-bonded interactions involving the key residues work as a snap to lock integrin in the bent form. The importance of the key residues for the conformational change was verified by mutation experiments.
Matsumoto, Atsushi; Iwasaki, Kenji*; Takagi, Junichi*
no journal, ,
Iwasaki, Kenji*; Matsumoto, Atsushi; Takagi, Junichi*
no journal, ,