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Saga, Ryo*; Matsuya, Yusuke; Takahashi, Rei*; Hasegawa, Kazuki*; Date, Hiroyuki*; Hosokawa, Yoichiro*
Scientific Reports (Internet), 11(1), p.8258_1 - 8258_10, 2021/04
Times Cited Count：4 Percentile：44.81(Multidisciplinary Sciences)Hyaluronan synthesis inhibitor 4-methylumbelliferone (4-MU) is a candidate of radiosensitizers in X-ray therapy. The curative effects under such 4-MU administration have been investigated in vitro; however, the radiosensitizing mechanisms remain unclear. Here, we investigated the radiosensitizing effects under 4-MU treatment from cell experiments and model estimations. We generated experimental surviving fractions of human fibrosarcoma cells (HT1080) after 4-MU treatment combined with X-ray irradiation. Meanwhilst, we also modelled the pharmacological effects of 4-MU treatment and theoretically analyzed the synergetic effects between 4-MU treatment and X-ray irradiation. The results show that the enhancement of cell killing by 4-MU treatment is the greatest in the intermediate dose range of around 4 Gy, which indicates the involvement of intercellular communication. In addition, the oxidative stress level, which leads to DNA damage induction, significantly increased under 4-MU treatment, and the radiosensitization by 4-MU can be suppressed by the inhibitors for intercellular communication. These findings suggest that the synergetic effects between 4-MU treatment and irradiation are predominantly attributed to intercellular communication and provide more efficient tumour control than conventional X-ray therapy.
Saga, Ryo*; Matsuya, Yusuke; Takahashi, Rei*; Hasegawa, Kazuki*; Date, Hiroyuki*; Hosokawa, Yoichiro*
Journal of Radiation Research, 60(3), p.298 - 307, 2019/05
Times Cited Count：23 Percentile：81.89(Biology)In radiotherapy, it is recognized that cancer stem cells (CSCs) in tumor tissue shows radio-resistance. However, the relationship between content percentage of the CSCs and dose-response curve on cell survival remain unclear. In this study, we developed a stochastic model considering progeny cells and stem cells, and investigated the impact of stem cells on radio-sensitivity. From the flow-cytometric analysis (cell experiments), the content percentage of stem cells was 3.2% or less which agreed well with the model estimation from the cell survival curve. Based on the verification, it is suggested that cell survival in high-dose range is largely affected by the CSCs. In addition, regarding the sub-population of stem cells, the present model well reproduces the dose response on lethal lesions to DNA comparing with the conventional LQ model. This outcome indicates that the stem cells must be considered for describing the dose-response curve in wide dose range.
Minami, Ryutaro*; Kariya, Tsuyoshi*; Imai, Tsuyoshi*; Numakura, Tomoharu*; Endo, Yoichi*; Nakabayashi, Hidetaka*; Eguchi, Taku*; Shimozuma, Takashi*; Kubo, Shin*; Yoshimura, Yasuo*; et al.
Nuclear Fusion, 53(6), p.063003_1 - 063003_7, 2013/06
Minami, Ryutaro*; Kariya, Tsuyoshi*; Imai, Tsuyoshi*; Numakura, Tomoharu*; Endo, Yoichi*; Nakabayashi, Hidetaka*; Eguchi, Taku*; Shimozuma, Takashi*; Kubo, Shin*; Yoshimura, Yasuo*; et al.
Nuclear Fusion, 53(6), p.063003_1 - 063003_7, 2013/06
Times Cited Count：12 Percentile：46.91(Physics, Fluids & Plasmas)Taguchi, Yasujiro*; Sakai, Hideaki*; Okuyama, Daisuke*; Ishiwata, Shintaro*; Fujioka, Jun*; Fukuda, Tatsuo; Hashizume, Daisuke*; Kagawa, Fumitaka*; Takahashi, Yoichiro*; Shimano, Ryo*; et al.
Physica B; Condensed Matter, 407(11), p.1685 - 1688, 2012/06
Times Cited Count：5 Percentile：23.80(Physics, Condensed Matter)Sugihara, Shinji*; Tanaka, Masahiro*; Tamari, Toshiya*; Shimada, Jun*; Takahashi, Tomoyuki*; Momoshima, Noriyuki*; Fukutani, Satoshi*; Atarashi-Andoh, Mariko; Sakuma, Yoichi*; Yokoyama, Sumi*; et al.
Fusion Science and Technology, 60(4), p.1300 - 1303, 2011/11
Times Cited Count：2 Percentile：18.18(Nuclear Science & Technology)The purpose of this study is to develop the technique to evaluate the environmental tritium behavior of the nuclear facility origin. Tritium concentrations of river water, precipitation and ground water around the NIFS site were determined by low background liquid scintillation measurement system combined with the electrolysis using solid polymer electrolyte. The electric conductivity and flow rate of the river and isotopic ratio of oxygen and hydrogen of water samples were also measured. The tritium concentrations in precipitation showed the seasonal variation and the range were 0.09-0.78 Bq/L. The tritium concentrations of river water and ground water were almost constant, 0.34 and 0.24 Bq/L respectively. The simple dynamic model for the site around the NIFS facilities was developed using measured data, and the behavior of tritium was simulated.
Kariya, Tsuyoshi*; Minami, Ryutaro*; Imai, Tsuyoshi*; Sakamoto, Keishi; Kubo, Shin*; Shimozuma, Takashi*; Takahashi, Hiromi*; Ito, Satoshi*; Muto, Takashi*; Mitsunaka, Yoshika*; et al.
Fusion Science and Technology, 55(2T), p.91 - 94, 2009/02
Times Cited Count：11 Percentile：59.56(Nuclear Science & Technology)
TiO
under hydrogen atmosphere conditionHoshino, Tsuyoshi; Tsuchiya, Kunihiko; Hayashi, Kimio; Terai, Takayuki*; Tanaka, Satoru*; Takahashi, Yoichi*
Fusion Engineering and Design, 75-79, p.939 - 943, 2005/11
Times Cited Count：13 Percentile：65.32(Nuclear Science & Technology)no abstracts in English
TiO added with TiOHoshino, Tsuyoshi; Kobayashi, Takeshi*; Nashimoto, Makoto*; Kawamura, Hiroshi; Dokiya, Masayuki*; Terai, Takayuki*; Yamawaki, Michio*; Takahashi, Yoichi*
JAERI-Conf 2004-012, p.140 - 147, 2004/07
no abstracts in English
TiOHoshino, Tsuyoshi; Kobayashi, Takeshi*; Nashimoto, Makoto*; Kawamura, Hiroshi; Terai, Takayuki*; Yamawaki, Michio*; Takahashi, Yoichi*
Journal of the Ceramic Society of Japan, Supplement, Vol.112, No.1 (CD-ROM), p.S354 - S357, 2004/05
no abstracts in English
Matsuda, Yasuhiro*; Ueda, Yuji*; Nojiri, Hiroyuki*; Takahashi, Toshiharu*; Inami, Toshiya; Owada, Kenji; Murakami, Yoichi; Arima, Takahisa*
Physica B; Condensed Matter, 346-347, p.519 - 523, 2004/04
Times Cited Count：51 Percentile：86.07(Physics, Condensed Matter)A very small capacitor bank and miniature pulsed magnets have been developed to perform high-field synchrotron radiation experiments. A 20T pulsed field can be generated using an energy of 1kJ with typical pulse duration about 1ms. Electron spin resonance experiments in millimeter wave range and high-field X-ray diffraction experiments have been done successfully.
Hanzawa, Yukiko; Magara, Masaaki; Watanabe, Kazuo; Esaka, Fumitaka; Miyamoto, Yutaka; Yasuda, Kenichiro; Gunji, Katsubumi*; Yamamoto, Yoichi; Takahashi, Tsukasa; Sakurai, Satoshi; et al.
JAERI-Tech 2002-103, 141 Pages, 2003/02
JAERI-Tech-2002-103.pdf:10.38MB
The JAERI has established a facility with a cleanroom: the Clean Laboratory for Environmental Analysis and Research (CLEAR). This report is an overview of the design, construction and performance evaluation of the CLEAR in the initial stage of the laboratory operation in June 2001. The CLEAR is a facility to be used for ultra trace analyses of nuclear materials in environmental samples for the safeguards, for the CTBT verification and for researches on environmental sciences. The CLEAR meets double requirements of a cleanroom and for handling of nuclear materials. Much attention was paid to the construction materials of the cleanroom for trace analysis of metal elements using corrosive acids. The air conditioning and purification system, experimental equipment, utilities and safety systems are also demonstrated. The potential contamination from the completed cleanroom atmosphere during the analytical procedure was evaluated. It can be concluded that the CLEAR has provided a suitable condition for reliable analysis of ultra trace amounts of nuclear materials in environmental samples.
; Yamauchi, Toshihiko; ; ; Yoshida, Hidetoshi; Kozawa, Teruo; ; ; D.Dimock*; B.LeBlanc*; et al.
JAERI-Tech 98-048, 49 Pages, 1998/10
no abstracts in English
Takemura, Tomoyuki*; Shingu, Kazuki*; Takahashi, Eiichiro*; Okada, Yoichi*; Takebe, Akimitsu*; Nakajima, Toshihide*; Inoue, Toshio*
JNC TJ7420 2005-033, 128 Pages, 1998/03
JNC-TJ7420-2005-033.pdf:51.98MB
The active fault survey tunnel that crossed the Mozumi-Sukenobu fault (a member of the Atotsugawa fault system) is located at the Kamioka mine, northern Gifu prefecture, Central Japan. The comprehensive study of the active fault is done by using this tunnel. The purpose of this investigation is to define the hydrological characteristics of the Mozumi-Sukenobu fault crush zones. The permeability of the crush zones is measured by the Lugeon test and the simple injection test.
tobermorite in aqueous solutionIkeda, Yasuhisa*; Yasuike, Yoshiyuki*; Takahashi, Koichi*; Yamamoto, Mitsuo*; Takahashi, Yoichi*
Nihon Seramikkusu Kyokai Gakujutsu Rombunshi, 101(1170), p.145 - 148, 1993/02
None
Sn demo poloidal coil(DPC-EX)Ando, Toshinari; Takahashi, Yoshikazu; Okuno, Kiyoshi; Tsuji, Hiroshi; Hiyama, Tadao; Nishi, Masataka; Tada, Eisuke; Yoshida, Kiyoshi; Koizumi, Norikiyo; Nakajima, Hideo; et al.
IEEE Transactions on Magnetics, 28(1), p.206 - 209, 1992/01
Times Cited Count：4 Percentile：47.72(Engineering, Electrical & Electronic)no abstracts in English
Sn demo poloidal coil(DPC-EX)Takahashi, Yoshikazu; Yoshida, Kiyoshi; Ando, Toshinari; Hiyama, Tadao; Tsuji, Hiroshi; Nishi, Masataka; Tada, Eisuke; Okuno, Kiyoshi; Koizumi, Koichi; Nakajima, Hideo; et al.
Cryogenics, 31, p.640 - 644, 1991/07
Times Cited Count：12 Percentile：66.78(Thermodynamics)no abstracts in English
Sn Demo Poloidal Coil(DPC-EX)Ando, Toshinari; Hiyama, Tadao; Tsuji, Hiroshi; Takahashi, Yoshikazu; Nishi, Masataka; Tada, Eisuke; Yoshida, Kiyoshi; Okuno, Kiyoshi; Koizumi, Koichi; Nakajima, Hideo; et al.
Fusion Technology 1990, p.243 - 247, 1991/00
no abstracts in English
Tada, Eisuke; Kato, Takashi; Hiyama, Tadao; Kawano, Katsumi; Ando, Toshinari; Tsuji, Hiroshi; Takahashi, Yoshikazu; Nishi, Masataka; Yoshida, Kiyoshi; Okuno, Kiyoshi; et al.
Proc. of the 11th Int. Conf. on Magnet Technology, p.830 - 834, 1990/00
no abstracts in English
; ; ;
Netsu Sokutei, 7(4), p.107 - 111, 1980/00
no abstracts in English
