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Journal Articles

Resumption of radioisotope production in the Research Reactor JRR-3

Endo, Akira

Isotope News, (781), P. 3, 2022/06

The research reactor JRR-3 at the Nuclear Science Research Institute of Japan Atomic Energy Agency resumed its operation in February 2021 for the first time in 10 years. After commissioning, neutron beam experimental apparatus and irradiation facilities were used from July to November, and the operation in 2021 was completed as planned. During this period, Ir-192 and Au-198 were produced and supplied for therapeutic use, and test irradiation for the production of Mo-99 was performed. This is resumption of radioisotope production using nuclear reactors in Japan, which had stopped after the Great East Japan Earthquake. This article introduces future efforts of radioisotope production for medical applications in JRR-3.

Journal Articles

Large scale production of $$^{64}$$Cu and $$^{67}$$Cu via the $$^{64}$$Zn(n, p)$$^{64}$$Cu and $$^{68}$$Zn(n, np/d)$$^{67}$$Cu reactions using accelerator neutrons

Kawabata, Masako*; Motoishi, Shoji*; Ota, Akio*; Motomura, Arata*; Saeki, Hideya*; Tsukada, Kazuaki; Hashimoto, Shintaro; Iwamoto, Nobuyuki; Nagai, Yasuki*; Hashimoto, Kazuyuki*

Journal of Radioanalytical and Nuclear Chemistry, 330(3), p.913 - 922, 2021/12

 Times Cited Count:7 Percentile:75.12(Chemistry, Analytical)

Both $$^{64}$$Cu and $$^{67}$$Cu are promising radionuclides in nuclear medicine. Production yields of these radionuclides were quantified by irradiating 55.4 g of natural zinc with accelerator neutrons. Clinically suitable $$^{64}$$Cu and $$^{67}$$Cu yields were estimated by experimental based numerical simulations using 100 g of enriched $$^{64}$$Zn and $$^{68}$$Zn, respectively, and elevated neutron fluxes from 40 MeV, 2 mA deuterons. A combined thermal- and resin-separation method was developed to isolate $$^{64}$$Cu and $$^{67}$$Cu from zinc, resulting in 73% separation efficiency and 97% zinc recovery. Such methods can provide large scale production of $$^{64}$$Cu and $$^{67}$$Cu for clinical applications.

Journal Articles

Mesoporous alumina-titania composites with enhanced molybdenum adsorption towards medical radioisotope production

Benu, D. P.*; Earnshaw, J.*; Ashok, A.*; Tsuchiya, Kunihiko; Saptiama, I.*; Yuliarto, B.*; Suendo, V.*; Mukti, R. R.*; Fukumitsu, Nobuyoshi*; Ariga, Katsuhiko*; et al.

Bulletin of the Chemical Society of Japan, 94(2), p.502 - 507, 2021/02

 Times Cited Count:11 Percentile:64.63(Chemistry, Multidisciplinary)

no abstracts in English

Journal Articles

$$^{99}$$Mo yield using large sample mass of MoO$$_{3}$$ for sustainable production of $$^{99}$$Mo

Tsukada, Kazuaki; Nagai, Yasuki*; Hashimoto, Kazuyuki*; Kawabata, Masako*; Minato, Futoshi; Saeki, Hideya*; Motoishi, Shoji*; Ito, Masatoshi*

Journal of the Physical Society of Japan, 87(4), p.043201_1 - 043201_5, 2018/04

 Times Cited Count:10 Percentile:59.63(Physics, Multidisciplinary)

Journal Articles

New production method and applications of $$^{67}$$Cu suitable for both cancer diagnosis and therapy

Nagai, Yasuki*; Tsukada, Kazuaki

Isotope News, (753), p.28 - 32, 2017/10

no abstracts in English

Journal Articles

Deuteron nuclear data for the design of accelerator-based neutron sources; Measurement, model analysis, evaluation, and application

Watanabe, Yukinobu*; Kin, Tadahiro*; Araki, Shohei*; Nakayama, Shinsuke; Iwamoto, Osamu

EPJ Web of Conferences, 146, p.03006_1 - 03006_6, 2017/09

 Times Cited Count:2 Percentile:77.79(Nuclear Science & Technology)

The design of $$(d,xn)$$ neutron sources requires comprehensive nuclear data of deuteron-induced reactions. Therefore, we have launched a research project on deuteron nuclear data, which is composed of measurements, theoretical model code development, cross section evaluation, and application to production of radioisotopes for medical use. Our goal is to develop a state-of-art deuteron nuclear data library up to 200 MeV necessary for the design of accelerator neutron sources with deuteron beam. The present status is reported in the presentation.

Journal Articles

Application of $$^{67}$$Cu produced by $$^{68}$$Zn($$n,n'p+d$$)$$^{67}$$Cu to biodistribution study in tumor-bearing mice

Sugo, Yumi*; Hashimoto, Kazuyuki*; Kawabata, Masako*; Saeki, Hideya*; Sato, Shunichi*; Tsukada, Kazuaki; Nagai, Yasuki*

Journal of the Physical Society of Japan, 86(2), p.023201_1 - 023201_3, 2017/02

 Times Cited Count:14 Percentile:67.59(Physics, Multidisciplinary)

$$^{67}$$Cu produced by the $$^{68}$$Zn($$n,n'p+d$$)$$^{67}$$Cu reaction was used for the first time to determine the biodistribution of $$^{67}$$CuCl$$_{2}$$ in colorectal tumor-bearing mice. High uptake of $$^{67}$$Cu was observed in the tumor as well as in the liver and kidney which are the major organs for copper metabolism. The result showing $$^{67}$$Cu accumulation in the tumor suggests that $$^{67}$$CuCl$$_{2}$$ can be a potential radionuclide agent for cancer radiotherapy. It would also encourage further studies on the therapeutic effect in small animals using an increased dose of $$^{67}$$Cu produced by the $$^{68}$$Zn($$n,n'p+d$$)$$^{67}$$Cu reaction using intense neutrons available at present.

Journal Articles

Present status of radioisotope production for medical use with reactors and a cyclotron in JAERI

Proc. of Korea Atomic Industrial Forum,Inc., p.347 - 357, 1997/04

no abstracts in English

Journal Articles

Impression of Japan-Russia Seminar on Utilization of Radiation and Radioisotopes for Medical Purposes

Isotope News, 0(483), p.38 - 39, 1994/09

no abstracts in English

Journal Articles

Second EUROMET comparison of air kerma rate and activity measurements of $$^{192}$$Ir brachytherapy wires

D.F.G.Reher*; A.H.L.Aalbers*; H.Bjerke*; N.Drugge*; Genka, Tsuguo; M.J.Rossiter*; D.Santry*; J.P.Sephton*; G.Sibbens*; J.Seuntjens*; et al.

Nuclear Instruments and Methods in Physics Research A, 339, p.386 - 390, 1994/00

 Times Cited Count:5 Percentile:53.31(Instruments & Instrumentation)

no abstracts in English

Journal Articles

Inhibition of oxidative degradation of polymer materials in radiation sterilization

Yoshii, Fumio

J. Radiat. Steril., 1, p.171 - 194, 1993/00

no abstracts in English

Journal Articles

Lowering the degradation in materials using electron beam sterilization

Yoshii, Fumio

Ika Kikaigaku, 62(2), p.78 - 86, 1992/02

no abstracts in English

Journal Articles

Radiation effects on polymer materials in radiation sterilization of medical supplies

Ishigaki, Isao; Yoshii, Fumio

Radiation Physics and Chemistry, 39(6), p.527 - 533, 1992/00

no abstracts in English

Journal Articles

The Present status of development of radioisotope sources in Russia

Genka, Tsuguo

Radioisotopes, 41(8), p.61 - 62, 1992/00

no abstracts in English

Journal Articles

Effect of electron beam irradiation for disinfection and sterilization

Ito, Hitoshi

Ika Kikaigaku, 60(10), p.469 - 475, 1990/10

no abstracts in English

Journal Articles

Radiation vulcanization of natural rubber latex

Makuuchi, Keizo

Isotope News, 0(2), p.10 - 12, 1990/02

no abstracts in English

Journal Articles

Damage of polymer materials in radiation sterilization

Yoshii, Fumio

Hoshasen Kagaku, 0(48), p.34 - 37, 1989/00

no abstracts in English

Journal Articles

Durability of radiation-sterilized polymers, XII; The effect of nucleating agent on the oxidative degradation of polypropylene

Z.A.Kadir*; Yoshii, Fumio; Makuuchi, Keizo; Ishigaki, Isao

Polymer, 30, p.1425 - 1432, 1989/00

 Times Cited Count:22 Percentile:72.31(Polymer Science)

no abstracts in English

Journal Articles

Electron beam sterilization considered from the standpoint of durability of the materials

;

Hoshasen To Sangyo, 32, p.15 - 20, 1986/00

no abstracts in English

Journal Articles

Durability of radiation-sterilized polymers,III;Oxidation layer determined by chemiluminescence

; ; ;

J.Appl.Polym.Sci., 31, p.1343 - 1350, 1986/00

 Times Cited Count:30 Percentile:81.14(Polymer Science)

no abstracts in English

49 (Records 1-20 displayed on this page)