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Sugo, Yumi*; Hashimoto, Kazuyuki*; Kawabata, Masako*; Saeki, Hideya*; Sato, Shunichi*; Tsukada, Kazuaki; Nagai, Yasuki*
Journal of the Physical Society of Japan, 86(2), p.023201_1 - 023201_3, 2017/02
Times Cited Count:14 Percentile:67.59(Physics, Multidisciplinary)Cu produced by the Zn()Cu reaction was used for the first time to determine the biodistribution of CuCl in colorectal tumor-bearing mice. High uptake of Cu was observed in the tumor as well as in the liver and kidney which are the major organs for copper metabolism. The result showing Cu accumulation in the tumor suggests that CuCl can be a potential radionuclide agent for cancer radiotherapy. It would also encourage further studies on the therapeutic effect in small animals using an increased dose of Cu produced by the Zn()Cu reaction using intense neutrons available at present.
Tsukada, Kazuaki; Watanabe, Satoshi*; Ishioka, Noriko*; Hatsukawa, Yuichi*; Hashimoto, Kazuyuki*; Sugo, Yumi*; Sato, Nozomi*; Kin, Tadahiro*; Kawabata, Masako*; Saeki, Hideya*; et al.
no journal, ,
A new system has been proposed for the generation of radioisotopes with accelerator neutrons by deuterons, especially the production of Mo-99, Y-90, Cu-67, and Cu-64. Enriched Mo-100, Zr-90, Zn-68 and Zn-64 oxide samples were irradiated with neutrons, which were obtained by the C(d,n) and Be(d,n) using 12 - 50 MeV deuterons provided from the TIARA cyclotron and the JAEA tandem accelerator. Mo-99, Y-90, Cu-67, and Cu-64 were successfully produced via the (n, x) reactions, and we clearly observed the -rays. The present results demonstrate that the radioisotopes, Mo-99, Y-90, Cu-67, and Cu-64, can be produced by using fast neutrons, and strongly suggest that the reaction system is one of the most promising routes to produce high quality medical radioisotope.