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Hartzell, S.*; Furutani, K. M.*; Parisi, A.*; 佐藤 達彦; 加瀬 優紀*; Deglow, C.*; Friedrich, T.*; Beltran, C. J.*
Radiation (Internet), 5(2), p.21_1 - 21_24, 2025/06
Microdosimetry is essential in particle therapy for understanding the biological effects of treatments by quantifying energy depositions within microscopic volumes. The calculation of the microdosimetric distributions can be carried out with physical models such as the Kiefer-Chatterjee (KC) track structure function and the Sato analytical microdosimetric function (AMF). Comprehensive comparisons across these physical models are lacking. The AMF is calculated for spherical domains, while the KC is traditionally calculated for a cylindrical domain. This study introduces a novel version of the KC function for spherical domains, allowing a direct comparison with AMF. The influence of each function on the calculation of the relative biological effectiveness (RBE) in carbon ion radiotherapy (CIRT) was evaluated.
Hartzell, S.*; Parisi, A.*; 佐藤 達彦; Beltran, C. J.*; Furutani, K. M.*
Physics in Medicine & Biology, 70(10), p.105010_1 - 105010_19, 2025/05
被引用回数：0 パーセンタイル：72.00(Engineering, Biomedical)In this study, we presented the implementation of the Analytical Microdosimetric Function (AMF) within the TOPAS Monte Carlo platform as an efficient and accurate surrogate for track structure simulations. The AMF extension demonstrated strong agreement with TOPAS nBio track structure simulations for ions relevant to particle therapy and space applications, while offering significant computational advantages.
Parisi, A.*; Furutani, K. M.*; 佐藤 達彦; Beltran, C. J.*
Medical Physics, 51(10), p.7589 - 7605, 2024/10
被引用回数：4 パーセンタイル：85.64(Radiology, Nuclear Medicine & Medical Imaging)本研究では、陽子線治療における生物学的相対有効性(RBE)モデルの課題に対処するため、LET(線量平均線エネルギー伝達)に基づく近似的なMKM(マイクロドシメトリックキネティックモデル)を開発した。これは、炭素イオン治療で使用されるメカニズムに基づくアプローチを陽子線に適用する試みでる。このLETベースのMKMは、線量平均LETと微生物学的指標の相関を確立し、複数の細胞株に対する生存率のモデリングに成功した。これにより、陽子線治療計画システムで容易に利用可能な物理量に基づくRBEの数学的記述が実現された。
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UParisi, A.*; Furutani, K. M.*; 佐藤 達彦; Beltran, C. J.*
Quantum Beam Science (Internet), 8(3), p.18_1 - 18_16, 2024/09
The analytical microdosimetric function (AMF) implemented in the Monte Carlo code PHITS is a unique tool that bridges the gap between macro- and microscopic scales of radiation interactions, enabling accurate microdosimetric calculations over macroscopic bodies. This study compares the older and newer AMFs in computing microdosimetric probability distributions, mean values, and the relative biological effectiveness (RBE). The newer AMF was found to offer superior performance, particularly for very heavy ions, producing results that align more closely with published in vitro clonogenic survival experiments. These findings suggest that the updated AMF provides a more reliable tool for microdosimetric calculations and RBE modeling, essential for ion radiation therapy and space radiation protection.
