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論文

Production of radioisotopes for nuclear medicine using ion beam technology and its utilization for both therapeutic and diagnostic application in cancer

飯田 靖彦*; 花岡 宏史*; 片渕 竜也*; 渡辺 智; 石岡 典子; 松橋 信平; 織内 昇*; 樋口 徹也*; 宮久保 満之*; 遠藤 啓吾*

JAEA-Review 2006-042, JAEA Takasaki Annual Report 2005, P. 165, 2007/02

Radioimmunotherapy (RIT) becomes one of the most promising treatments for cancer therapy. Recently, because various radioisotopes are being used for RIT, the efficient tailor-made therapy is thought to be possible. The high energy $$beta$$-particle-emitter, such as $$^{90}$$Y (2.28 MeV), seems particularly well suited for the treatment of relatively large tumor masses, but the middle energy $$beta$$-particles, such as $$^{67}$$Cu (0.18-0.58 MeV), may have an advantage in treating small lesions. In this study, we prepared $$^{67}$$Cu and evaluated its potential of application for RIT in tumor bearing mice. Our results of tumor localization studies show that $$^{67}$$Cu was expected to be suitable for RIT.

口頭

がん診断・治療における新規放射性核種の有用性

飯田 靖彦*; 花岡 宏史*; 吉岡 弘樹*; 宮久保 満之*; Paudyal, B.*; 樋口 徹也*; 織内 昇*; 遠藤 啓吾*; 片渕 竜也*; 石岡 典子; et al.

no journal, , 

近年、がん診断における$$^{18}$$F標識グルコース($$^{18}$$F-FDG)の有用性が明らかとなり、多数の施設においてPETによる画像診断が行われるようになっている。しかしながら、現在PETに用いられている放射性同位元素はいずれも半減期が短く、その利用には制限があるのが現状である。そこで、製薬会社において製造し、医療現場への供給が可能な半減期を有する新規PET用核種の製造とそれを用いた放射性薬剤の開発・有効性の確認に関する研究を進めている。本シンポジウムにおいては、新規核種として開発を進めている、$$^{64}$$Cu, $$^{67}$$Cu, $$^{76}$$Br, $$^{177}$$Luについて、それぞれの核種の特徴及び研究開発の進捗を紹介する。

口頭

Utility of $$^{64}$$Cu for immuno-PET; In vivo measurement of radiation dose for radioimmunotherapy

飯田 靖彦*; 花岡 宏史*; 片渕 竜也*; 渡辺 智; 石岡 典子; 松橋 信平; 織内 昇*; 樋口 徹也*; 宮久保 満之*; 遠藤 啓吾*

no journal, , 

Radioimmunotherapy (RIT) becomes one of the most promising treatments for cancer therapy. Recently, RIT becomes available for clinical use and shows high efficacy, but it has some adverse effects for radiation to normal tissues and its therapeutic window is limited. So, assessment of radiation dose deliver to both tumor and normal tissues is very important for RIT. PET is superior in quantitative measurement and it can estimate radiation dose directly. Although representative positron emitter has short half-life, which is not good for labeling of antibody, $$^{64}$$Cu has appropriate property, T$$_{1/2}$$ = 12.7 hr, and it may have a great potential for immuno-PET. In this study, we prepared a radioimmunoconjugate, NuB2, anti-CD20 monoclonal antibody (mAb), labeled with $$^{64}$$Cu, and evaluated potential for in vivo quantitative measurement of radiation dose for RIT. NuB2 was labeled with $$^{64}$$Cu. For in vivo studies, SCID mice bearing CD20$$^{+}$$ tumor were used. After administration, biodistribution and PET imaging were performed. For the results of biodistribution, $$^{64}$$Cu-NuB2 was highly accumulated to CD20$$^{+}$$ tumor, and PET images could show the same results. From these date, the use of $$^{64}$$Cu immuno-PET has potential for accurately measurement of radiation dose for RIT.

口頭

Application of PET imaging with $$^{64}$$Cu for quantitative evaluation of radioimmunotherapy

飯田 靖彦*; 花岡 宏史*; 片渕 竜也*; 渡辺 智; 石岡 典子; 松橋 信平; 織内 昇*; 樋口 徹也*; 宮久保 満之*; 遠藤 啓吾*

no journal, , 

$$^{64}$$Cu is one of the most attractive candidate emitter for radioimmunotherapy (RIT). $$^{64}$$Cu releases positron emitter (0.653 MeV, 18%) as well as middle energy $$beta$$-particles (0.578 MeV, 37%), so it can be applied for diagnostic imaging with PET. PET is superior in quantitative measurement and suitable for evaluation of therapeutic effect with RIT. PET can also directly estimate radiation dose of RIT. In this study, we prepared a radioimmunoconjugate, NuB2, anti-CD20 monoclonal antibody (mAb), labeled with $$^{64}$$Cu, and evaluated its potential for PET imaging with RIT. NuB2 was labeled with $$^{64}$$Cu. For in vivo studies, SCID mice bearing CD20$$^{+}$$ tumor were used. After administration, biodistribution and PET imaging were performed. For the results of biodistribution, $$^{64}$$Cu-NuB2 was highly accumulated to CD20$$^{+}$$ tumor, and PET images could show the same results. From these date, the use of $$^{64}$$Cu for PET imaging has potential for accurately evaluation of therapeutic effect of RIT.

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