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菊地 弘記*; 長嶺 竹明*; 時田 佳治*; 佐藤 隆博; 神谷 富裕
JAEA-Review 2011-043, JAEA Takasaki Annual Report 2010, P. 88, 2012/01
Erythrocyte is a specimen which is easy to use for the analysis of the trace elements in internal organs of living subjects and appropriate material to investigate the distributions of those elements. In this research, the trace elements of erythrocyte in hemo-dialysis patients were analyzed by in-air micro-PIXE, and the pathogenesis of the anemia in these patients were elucidated. The form of a normal erythrocyte shows a dent at the center of erythrocyte. A large number of erythrocytes in hemo-dialysis patient's bloods did not show a dent at the center of erythrocyte. The change of the erythrocyte form was also observed in patients with hereditary spherocytosis. Iron distribution was similar between the hemo-dialysis patients and healthy controls. Other elements did not show clear difference of distribution between the hemo-dialysis patients and healthy controls.
菊地 弘記*; 時田 佳治*; 長嶺 竹明*; 佐藤 隆博; 神谷 富裕
no journal, ,
本研究では、透析による貧血の病態解明を目的として、透析患者の赤血球中の微量元素を大気micro-PIXEを用いて分析した。その結果、透析患者と健常人のX線スペクトルに違いは見られなかったが、透析患者の赤血球は中心が窪んでいないものが多く、透析患者の赤血球の形態的変化が明らかとなった。