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Journal Articles

Experimental study of Gamow-Teller transitions via the high-energy-resolution $$^{18}$$O($$^3$$He,$$t$$)$$^{18}$$F reaction; Identification of the low-energy "super" -Gamow-Teller state

Fujita, Hirohiko*; Fujita, Yoshitaka*; Utsuno, Yutaka; Yoshida, Kenichi*; Adachi, Tatsuya*; Algora, A.*; Csatl$'o$s, M.*; Deaven, J. M.*; Estevez-Aguado, E.*; Guess, C. J.*; et al.

Physical Review C, 100(3), p.034618_1 - 034618_13, 2019/09

 Times Cited Count:2 Percentile:52.25(Physics, Nuclear)

no abstracts in English

Journal Articles

Seven cysteine-deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1

Nakaniwa, Tetsuko*; Fukata, Harumi*; Inoue, Tatsuya*; Goda, Masaki*; Nakai, Ryoko*; Kirii, Yasuyuki*; Adachi, Motoyasu; Tamada, Taro; Segawa, Shinichi*; Kuroki, Ryota; et al.

Biochemistry, 51(42), p.8410 - 8421, 2012/10

 Times Cited Count:13 Percentile:63.79(Biochemistry & Molecular Biology)

Protein kinase is a vital drug target for the treatment of a wide range of diseases. To investigate the effect of cysteine mutation on the function, stability and structure of kinase, free cysteines of c-Jun N-terminal kinase 1 (JNK1) were systematically removed by mutation. Two cysteine-destructed mutants in which three (M3) and seven (M7) cysteine residues are removed, yielded about 5 and 2 times than wild type JNK-1 (M0). SDS PAGE analysis showed that the aggregation was less in the case of M3 and M7. Thermal unfolding experiment of M0, M3 and M7 using by differential scanning calorimetry proceeded at least three state unfolding. Crystal structure of the M3 mutant was determined to 2.6 ${AA}$ resolution, which was identical to that of the wild-type. Consequently, due to the highest yield, its improved stability against aggregation and its structural similarity to the wild type, the M3 mutant is suitable for the use of further characterization of its function and structure.

Journal Articles

Current status of the control system for J-PARC accelerator complex

Yoshikawa, Hiroshi; Sakaki, Hironao; Sako, Hiroyuki; Takahashi, Hiroki; Shen, G.; Kato, Yuko; Ito, Yuichi; Ikeda, Hiroshi*; Ishiyama, Tatsuya*; Tsuchiya, Hitoshi*; et al.

Proceedings of International Conference on Accelerator and Large Experimental Physics Control Systems (ICALEPCS '07) (CD-ROM), p.62 - 64, 2007/10

J-PARC is a large scale facility of the proton accelerators for the multi-purpose of scientific researches in Japan. This facility consists of three accelerators and three experimental stations. Now, J-PARC is under construction, and LINAC is operated for one year, 3GeV synchrotron has just started the commissioning in this October the 1st. The completion of this facility will be next summer. The control system of accelerators established fundamental performance for the initial commissioning. The most important requirement to the control system of this facility is to minimize the activation of accelerator devices. In this paper, we show that the performances of each layer of this control system have been achieved in the initial stage.

Oral presentation

Improvement of crystal packing of human MAP kinase JNK1 by point mutation for neutron crystallography

Nakaniwa, Tetsuko*; Fukata, Harumi*; Inoue, Tatsuya*; Kinoshita, Takayoshi*; Adachi, Motoyasu; Tamada, Taro; Kuroki, Ryota; Tada, Toshiji*

no journal, , 

JNK1 is a MAP kinase responsible for response of stress. JNK1 has 4 and 3 cysteine residues in embedded region and at molecular surface, respectively. Those cysteine residues would cause inactivation and aggregation of the molecule. Based of the analysis of packing in crystal of isozyme of JNK1, we found more salt bridge and hydrogen bonding interactions on the interface. In this study, we focus on the two cysteine residues and introduced modification into M3 mutant previously reported.

Oral presentation

Study on the generation process of radioactive particles emitted from Unit 1 of FDNPP

Ishii, Tatsuya*; Sueki, Keisuke*; Matsuo, Kazuki*; Kurosawa, Masanori*; Satou, Yukihiko; Kobata, Masaaki; Fukuda, Tatsuo; Yoshii, Kenji; Tanida, Hajime; Okane, Tetsuo; et al.

no journal, , 

Radioactive particles were released into the environment by the accident of Fukushima Daiichi Nuclear Power Plant (FDNPP). They have information to understand the inside of the reactor during the accident. Now, nobody knows the generation process of radioactive particles. In this study, we analyzed (1) elements of particles' cross section with SEM-EDS to reveal what is the material and (2) chemical states of elements on particles' surface with HAXPES. (1) Radioactive particles are composed of the two parts. One is the basic material and the other is the heavy elemental materials. We considered the basic material was soda-lime glass and the heavy elemental materials included lead glass. (2) HAXPES brought out that the chemical states of Cs on particles, surface was different in the Na-poor areas and the Na-rich areas. In the Na-poor areas, the chemical state of Cs showed CsFeSiO$$_4$$ mainly, but zero valence partly. In the Na-rich areas, the chemical state of Cs couldn't be identified. For above analyses, we can reveal the generation process of radioactive particles.

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