Intracellular changes of metal elements by fucoidan extracted from brown seaweed;

Nagamine, Takeaki*; Takada, Hisashi*; Kusakabe, Takahiko*; Nakazato, Kyomi*; Sakai, Takuro; Oikawa, Masakazu*; Kamiya, Tomihiro; Arakawa, Kazuo; Iha, Masahiko*

Biological Trace Element Research, 124(1), p.60 - 69, 2008/07

https://doi.org/10.1007/s12011-008-8123-x

This study was undertaken to elucidate the intracellular changes of metal elements after the administration of fucoidan extracted from . TRL1215 cells (normal rat liver cell line) were treated with 0, 0.1, or 1.0 mg/mL fucoidan. The cellular distribution of elements was analyzed using in-air micro-PIXE induced X-ray emission. In fucoidan-treated cells, the focal accumulation of Br (BrdU) was correlated spatially with phosphorous-rich region, suggesting that Br was localized within the nucleus. Al distribution provided a spatial association with Br map. These data suggest that fucoidan binding Al us postulated to be transferred into the nucleus.

Research of disease onset mechanism by determining the distribution of intracellular trace elements using an in-air micro-PIXE analyzer system

Nakano, Takashi*; Arakawa, Kazuo; Sakurai, Hideyuki*; Hasegawa, Masatoshi*; Yuasa, Kazuhisa*; Saito, Etsuko*; Takagi, Hitoshi*; Nagamine, Takeaki*; Kusakabe, Takahiko*; Takada, Hisashi*; et al.

International Journal of PIXE, 16(1&2), p.69 - 76, 2006/00

https://doi.org/10.1142/S0129083506000824

A new program was started out to create a new medical scientific field, which is consisting of radiation oncology and nuclear medicine, utilizing the advanced accelerator and ion beam technology. An in-air micro-PIXE analyzer system, which is among the most important technical basis of the program, was upgraded to improve accuracy of elemental mapping for samples having thickness variation in a scope of microbeam scanning. In the program, on the other hand, in order to approach important bio-medical problems on cancer, intracellular dynamics of the trace elements according to mechanism of development of diseases were studied using this system. This paper outlines this program and shows the system upgraded, and results of preliminary studied about the problems.

A study on in-situ measuring method and modeling technique of an unsaturated zone

Imai, Hisashi; Amemiya, Kiyoshi*; Kato, Takashi*; Nishida, Kaoru*; Arakawa, Tetsuichi*; Maemura, Tsuneyuki*

JNC TJ7400 99-009, 318 Pages, 1999/02

JNC-TJ7400-99-009.pdf:15.91MB

None

Development of a heat-resistant magnetic sensor

Takaya, Shigeru; Arakawa, Hisashi*; Keyakida, Satoshi*

no journal, , 

A heat-resistant flux gate magnetic sensor has been developed. Permendur, which has high Curie temperature, is employed as the magnetic core material and the detection method of the external magnetic field is modified. The characteristics of the developed magnetic sensor at 300C were evaluated. The sensor output increases linearly with the external magnetic field in the range of 5 G and the sensitivity is about 0.89 G.

Recent development of the plasma diagnostics for JT-60SA

Itami, Kiyoshi; Shinohara, Koji; Hatae, Takaki; Kamiya, Kensaku; Fukumoto, Masakatsu; Nakano, Tomohide; Yoshida, Maiko; Tojo, Hiroshi; Arakawa, Hiroyuki; Kokusen, Shigeharu; et al.

no journal, , 

Development of heat-resistant magnetic sensor

Takaya, Shigeru; Arakawa, Hisashi*; Keyakida, Satoshi*

no journal, , 

A hear-resistant magnetic sensor was newly developed. Permendur, a high Curie temperature material, was employed as a magnetic core material, and magnetic detection principle was modified by taking the magnetic property of Permendur into account. It was shown that sensor output is linear with respect to external magnetic field at least up to 500C, though sensitivity decreased slightly with temperature. Effect of oxidation of magnetic core was investigated, but it was concluded that oxidation of magnetic core is not major factor of decreasing in sensitivity.