Refine your search:     
Report No.
 - 
Search Results: Records 1-20 displayed on this page of 247

Presentation/Publication Type

Initialising ...

Refine

Journal/Book Title

Initialising ...

Meeting title

Initialising ...

First Author

Initialising ...

Keyword

Initialising ...

Language

Initialising ...

Publication Year

Initialising ...

Held year of conference

Initialising ...

Save select records

Journal Articles

Evaluation of phase bunching in the central region of a cyclotron by a radial probe with a plastic scintillator

Miyawaki, Nobumasa; Fukuda, Mitsuhiro*; Kurashima, Satoshi; Kashiwagi, Hirotsugu; Okumura, Susumu; Arakawa, Kazuo*; Kamiya, Tomihiro

Nuclear Instruments and Methods in Physics Research A, 767, p.372 - 378, 2014/12

 Times Cited Count:3 Percentile:30.04(Instruments & Instrumentation)

Journal Articles

Time resolution of beam phase distribution measurement system for the JAEA AVF cyclotron

Miyawaki, Nobumasa; Fukuda, Mitsuhiro*; Kurashima, Satoshi; Kashiwagi, Hirotsugu; Okumura, Susumu; Arakawa, Kazuo*; Kamiya, Tomihiro

Proceedings of 11th Annual Meeting of Particle Accelerator Society of Japan (Internet), p.1179 - 1181, 2014/10

no abstracts in English

Journal Articles

Analysis of phase bunching in a central region of a cyclotron

Miyawaki, Nobumasa; Fukuda, Mitsuhiro*; Kurashima, Satoshi; Kashiwagi, Hirotsugu; Okumura, Susumu; Arakawa, Kazuo*; Kamiya, Tomihiro

Proceedings of 10th Annual Meeting of Particle Accelerator Society of Japan (Internet), p.500 - 502, 2014/06

no abstracts in English

Journal Articles

Geometric analysis of phase bunching in the central region of cyclotron

Miyawaki, Nobumasa; Fukuda, Mitsuhiro*; Kurashima, Satoshi; Kashiwagi, Hirotsugu; Okumura, Susumu; Arakawa, Kazuo*; Kamiya, Tomihiro

Nuclear Instruments and Methods in Physics Research A, 715, p.126 - 131, 2013/07

 Times Cited Count:2 Percentile:21.46(Instruments & Instrumentation)

An optimum condition for realizing phase bunching in the central region of a cyclotron was quantitatively clarified by a simplified geometric trajectory analysis of charged particles from the first to the second acceleration gap. The phase-bunching performance was evaluated for a general case of a cyclotron. The phase difference of incident particles at the second acceleration gap depends on the combination of four parameters: the acceleration harmonic number ${it h}$, the span angle ${it $theta$$_{D}$}$ of the dee electrode, the span angle ${it $theta$$_{F}$}$ from the first to the second acceleration gap, the ratio ${it R$_{V}$}$ of the peak acceleration voltage between the cyclotron and ion source. Optimum values of ${it $theta$$_{F}$}$ for phase bunching were limited by the relationship between ${it h}$ and ${it $theta$$_{D}$}$, which is 90$$^{circ}$$/${it h}$+${it $theta$$_{D}$}$/2 $$leq$$ ${it $theta$$_{F}$}$ $$leq$$ 180$$^{circ}$$/${it h}$+${it $theta$$_{D}$}$/2, and sin${it $theta$$_{F}$}$ $$>$$ 0. The phase difference with respect to the reference particle at the second acceleration gap is minimized for voltage-ratios between two and four for an initial phase difference within 40 RF degrees. Although the slope of the first acceleration gap contributes to the RF phase at which the particles reach the second acceleration gap, phase bunching was not affected. An orbit simulation of the JAEA AVF cyclotron verifies the evaluation based on geometric analysis.

Journal Articles

Three-dimensional and multienergy $$gamma$$-ray simultaneous imaging by using a Si/CdTe Compton camera

Suzuki, Yoshiyuki*; Yamaguchi, Mitsutaka; Odaka, Hirokazu*; Shimada, Hirofumi*; Yoshida, Yukari*; Torikai, Kota*; Sato, Takahiro; Arakawa, Kazuo*; Kawachi, Naoki; Watanabe, Shigeki; et al.

Radiology, 267(3), p.941 - 947, 2013/06

 Times Cited Count:10 Percentile:42.69(Radiology, Nuclear Medicine & Medical Imaging)

Journal Articles

An Evaluation of three-dimensional imaging by use of Si/CdTe Compton cameras

Yamaguchi, Mitsutaka; Nagao, Yuto; Kawachi, Naoki; Fujimaki, Shu; Kamiya, Tomihiro; Odaka, Hirokazu*; Kokubun, Motohide*; Takeda, Shinichiro*; Watanabe, Shin*; Takahashi, Tadayuki*; et al.

Proceedings of 2013 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC), 3 Pages, 2013/00

Journal Articles

A New method for monitoring beam range by measuring low energy photons

Yamaguchi, Mitsutaka; Torikai, Kota*; Kawachi, Naoki; Shimada, Hirofumi*; Sato, Takahiro; Nagao, Yuto; Fujimaki, Shu; Kokubun, Motohide*; Watanabe, Shin*; Takahashi, Tadayuki*; et al.

Proceedings of 2013 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC), 2 Pages, 2013/00

Journal Articles

Beam range estimation by measuring bremsstrahlung

Yamaguchi, Mitsutaka; Torikai, Kota*; Kawachi, Naoki; Shimada, Hirofumi*; Sato, Takahiro; Nagao, Yuto; Fujimaki, Shu; Kokubun, Motohide*; Watanabe, Shin*; Takahashi, Tadayuki*; et al.

Physics in Medicine & Biology, 57(10), p.2843 - 2856, 2012/05

 Times Cited Count:21 Percentile:65.06(Engineering, Biomedical)

Journal Articles

Three-dimensional imaging test for a head module of a Si/CdTe Compton camera for medical application

Yamaguchi, Mitsutaka; Kawachi, Naoki; Kamiya, Tomihiro; Sato, Takahiro; Suzui, Nobuo; Fujimaki, Shu; Odaka, Hirokazu*; Ishikawa, Shinnosuke*; Kokubun, Motohide*; Watanabe, Shin*; et al.

JAEA-Review 2011-043, JAEA Takasaki Annual Report 2010, P. 145, 2012/01

no abstracts in English

Journal Articles

Analysis on the co-localization of asbestos bodies and Fas or CD163 expression in asbestos lung tissue by in-air micro-PIXE

Dobashi, Kunio*; Shimizu, Yasuo*; Matsuzaki, Shinichi*; Nagamine, Takeaki*; Sato, Takahiro; Okubo, Takeru; Yokoyama, Akihito; Ishii, Yasuyuki; Kamiya, Tomihiro; Arakawa, Kazuo*; et al.

JAEA-Review 2011-043, JAEA Takasaki Annual Report 2010, P. 87, 2012/01

Journal Articles

Development of head module for multi-head Si/CdTe Compton camera for medical applications

Yamaguchi, Mitsutaka; Kawachi, Naoki; Suzui, Nobuo; Fujimaki, Shu; Kamiya, Tomihiro; Odaka, Hirokazu*; Ishikawa, Shinnosuke*; Kokubun, Motohide*; Watanabe, Shin*; Takahashi, Tadayuki*; et al.

Nuclear Instruments and Methods in Physics Research A, 648(Suppl.1), p.S2 - S7, 2011/08

 Times Cited Count:1 Percentile:12.7(Instruments & Instrumentation)

We are constructing a three-dimensional imaging system for medical and biological applications. The system will allow simultaneous imaging at high spatial and energy resolutions across a wide energy range, from several tens of keV to a few MeV. In this work, one prototype head module have been developed for a multi-head Si/CdTe Compton camera system. The performance of the prototype was evaluated with a sealed Ba-133 radiation source. The experiments confirmed that the imaging results were consistent with actual source position. In addition to the resolution for the parallel directions to the detector surface, the position resolution was evaluated for the depth direction at a point in near region of the head-module. These position resolutions were well reproduced by Monte Carlo simulation results.

Journal Articles

Realization of a phase bunching effect for minimization of beam phase width in a central region of an AVF cyclotron

Miyawaki, Nobumasa; Fukuda, Mitsuhiro*; Kurashima, Satoshi; Okumura, Susumu; Kashiwagi, Hirotsugu; Nara, Takayuki; Ishibori, Ikuo; Yoshida, Kenichi; Yokota, Wataru; Nakamura, Yoshiteru*; et al.

Nuclear Instruments and Methods in Physics Research A, 636(1), p.41 - 47, 2011/04

 Times Cited Count:5 Percentile:42.62(Instruments & Instrumentation)

A phase bunching effect has been achieved for the first time using a rising slope of the dee voltage waveform produced at the first acceleration gap between the RF shielding cover of the inflector and the puller in the new central region of the JAEA AVF cyclotron. The feasibility of the phase bunching effect in the central region for a two-dee system with a span angle of 86 $$^{circ}$$ in three acceleration harmonic modes was assessed by a simple geometrical analysis of particle trajectories and a three-dimensional beam orbit simulation. The simulation indicated that the initial beam phase width of 40 RF degrees is compressed to 11 RF degrees in the second harmonic mode. A phase width of 1.5 RF degrees FWHM for a 260 MeV $$^{20}$$Ne$$^{7+}$$ beam accelerated in the second harmonic mode was reduced by the bunching effect, compared with the beam phase width of 7.3 RF degrees FWHM in the same harmonic mode for a 10 MeV H$$^{+}$$ beam accelerated in the original central region.

Journal Articles

Counting rate performance measurement of newly developed Si/CdTe Compton camera for biological and medical applications

Yamaguchi, Mitsutaka; Kawachi, Naoki; Kamiya, Tomihiro; Suzui, Nobuo; Fujimaki, Shu; Odaka, Hirokazu*; Ishikawa, Shinnosuke*; Kokubun, Motohide*; Watanabe, Shin*; Takahashi, Tadayuki*; et al.

2010 IEEE Nuclear Science Symposium Conference Record (CD-ROM), p.2004 - 2007, 2010/10

Journal Articles

Quantitative analysis of cisplatin sensitivity of human esophageal squamous cancer cell lines using in-air micro-PIXE

Tanaka, Naritake*; Kimura, Hitoshi*; Faried, A.*; Sakai, Makoto*; Sano, Takaaki*; Inose, Takanori*; Soda, Makoto*; Okada, Koji*; Nakajima, Masanobu*; Miyazaki, Tatsuya*; et al.

Cancer Science, 101(6), p.1487 - 1492, 2010/06

 Times Cited Count:12 Percentile:34.46(Oncology)

We examined the intracellular localization of cisplatin, a key chemotherapeutic agent, in esophageal cancer cell lines and determined their sensitivity to cisplatin using in-air micro-PIXE. Two human esophageal squamous cell carcinoma (ESCC) cell lines, TE-2 and TE-13, were examined for their response to cisplatin using MTT assay, flow cytometry and DNA fragmentation assays. Real-time reverse transcription-polymerase chain reaction was also used to evaluate the mRNA expression of multidrug resistance protein 2 (MRP2) in both cell lines. Platinum localizations of intracellular and intranuclear were measured using in-air micro-PIXE. TE-2 cells were more sensitive to cisplatin than TE-13 cells. The results of this study suggest that in-air micro-PIXE could be a useful quantitative method for evaluating the cisplatin sensitivity of individual cells. Finally, we speculate that MRP2 in the cell membrane may play an important role in regulating cisplatin sensitivity of ESCC cells.

Journal Articles

Analysis on the Co-localization of asbestos bodies and Fas or CD163 expression in asbestos lung tissue by in-air micro-PIXE

Matsuzaki, Shinichi*; Shimizu, Yasuo*; Dobashi, Kunio*; Nagamine, Takeaki*; Sato, Takahiro; Okubo, Takeru; Yokoyama, Akihito; Ishii, Yasuyuki; Kamiya, Tomihiro; Arakawa, Kazuo*; et al.

International Journal of Immunopathology and Pharmacology, 23(1), p.1 - 11, 2010/01

Journal Articles

Single-turn extraction from a K110 AVF cyclotron by flat-top acceleration

Kurashima, Satoshi; Miyawaki, Nobumasa; Okumura, Susumu; Ishibori, Ikuo; Nara, Takayuki; Agematsu, Takashi; Yoshida, Kenichi; Yokota, Wataru; Nakamura, Yoshiteru*; Arakawa, Kazuo; et al.

Review of Scientific Instruments, 80(3), p.033302_1 - 033302_9, 2009/03

 Times Cited Count:5 Percentile:28.36(Instruments & Instrumentation)

Single-turn extraction from the JAEA AVF cyclotron with a K number of 110 using a flat-top (FT) acceleration system has been achieved to reduce the energy spread of an ion beam for microbeam formation with energy up to hundreds of MeV and to increase extraction efficiency from the cyclotron. In order to generate an FT waveform voltage using the fifth-harmonic frequency on a dee electrode, an FT resonator was designed using MAFIA code to achieve downsizing and low power consumption. The FT resonator, coupled to the main resonator through a coupling capacitor, covered the full range of the fifth harmonic frequency from 55 to 110 MHz. Various ion beams, accelerated using different acceleration harmonic mode of h = 1 and 2, such as 220 MeV $$^{12}$$C$$^{5+}$$ (h = 2), 260 MeV $$^{20}$$Ne$$^{7+}$$ (h = 2), and 45 MeV H$$^{+}$$ (h = 1) were developed by FT acceleration. A clear turn separation of the beam bunches was successfully observed at the extraction region of the large-scale AVF cyclotron with number of revolutions greater than 200. As a result, high extraction efficiency (over 95%) from the cyclotron was achieved. Single-turn extraction was confirmed by counting the number of beam bunches out of the cyclotron for an injected beam pulsed by a beam chopping system in the injection line. The energy spread of the 260 MeV $$^{20}$$Ne$$^{7+}$$ beam was measured using an analyzing magnet and we verified a reduction of the energy spread from $$Delta$$E/E = 0.1% to 0.05% by single-turn extraction.

Journal Articles

Basic characteristics of a newly developed Si/CdTe Compton camera for medical imaging

Kawachi, Naoki; Watanabe, Shigeki; Sato, Takahiro; Arakawa, Kazuo; Takeda, Shinichiro*; Ishikawa, Shinnosuke*; Aono, Hiroyuki*; Watanabe, Shin*; Yamaguchi, Mitsutaka*; Takahashi, Tadayuki*; et al.

2008 IEEE Nuclear Science Symposium Conference Record (CD-ROM), p.1540 - 1543, 2008/10

Journal Articles

Monte Carlo simulation of multi-head Si/CdTe Compton camera for medical imaging

Yamaguchi, Mitsutaka*; Kawachi, Naoki; Watanabe, Shin*; Odaka, Hirokazu*; Takeda, Shinichiro*; Ishikawa, Shinnosuke*; Aono, Hiroyuki*; Takahashi, Tadayuki*; Arakawa, Kazuo; Nakano, Takashi*

2008 IEEE Nuclear Science Symposium Conference Record (CD-ROM), p.4000 - 4002, 2008/10

Journal Articles

Intracellular changes of metal elements by fucoidan extracted from brown seaweed; ${it Cladosiphon okamuranus}$

Nagamine, Takeaki*; Takada, Hisashi*; Kusakabe, Takahiko*; Nakazato, Kyomi*; Sakai, Takuro; Oikawa, Masakazu*; Kamiya, Tomihiro; Arakawa, Kazuo; Iha, Masahiko*

Biological Trace Element Research, 124(1), p.60 - 69, 2008/07

 Times Cited Count:2 Percentile:7.24(Biochemistry & Molecular Biology)

This study was undertaken to elucidate the intracellular changes of metal elements after the administration of fucoidan extracted from ${it Cladosiphon okamuranus}$. TRL1215 cells (normal rat liver cell line) were treated with 0, 0.1, or 1.0 mg/mL fucoidan. The cellular distribution of elements was analyzed using in-air micro-PIXE induced X-ray emission. In fucoidan-treated cells, the focal accumulation of Br (BrdU) was correlated spatially with phosphorous-rich region, suggesting that Br was localized within the nucleus. Al distribution provided a spatial association with Br map. These data suggest that fucoidan binding Al us postulated to be transferred into the nucleus.

JAEA Reports

Construction and commissioning of K110 AVF cyclotron

Arakawa, Kazuo; Yokota, Wataru; Agematsu, Takashi; Nakamura, Yoshiteru; Ishibori, Ikuo; Kurashima, Satoshi; Miyawaki, Nobumasa; Okumura, Susumu; Kamiya, Tomihiro; Nara, Takayuki; et al.

JAEA-Technology 2008-024, 141 Pages, 2008/03

JAEA-Technology-2008-024.pdf:14.07MB

The TIARA facilities (Takasaki Ion Accelerators for Advanced Radiation Application: TIARA) have been constructed at Takasaki Radiation Chemistry Research Establishment (Takasaki Advanced Radiation Research Institute) under 6-year program from 1988. The first phase of the construction including those of a K110 AVF cyclotron and a 3 MV tandem accelerator was complete in October 1991. Large AVF cyclotrons have been used mostly for fundamental nuclear physics and medical applications to radiation therapy and radioisotope production so far. The JAEA K110 AVF cyclotron is the first one dedicated to R&D in materials science and other irradiation purpose. This cyclotron facility consists of three external ion sources, an injection line, a K110 AVF cyclotron, eight main beam transport lines, and a control system. The first beam, 50 MeV $$^{4}$$He$$^{2+}$$, was extracted from the cyclotron in March 1991. This Report describes an outline of the K110 AVF cyclotron system and results of performance tests.

247 (Records 1-20 displayed on this page)