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Journal Articles

Biological significance of fluorine-18-$$alpha$$-methyltyrosine (FAMT) uptake on PET in patients with oesophageal cancer

Suzuki, Shigemasa*; Kaira, Kyoichi*; Ohshima, Yasuhiro; Ishioka, Noriko; Soda, Makoto*; Yokobori, Takehiko*; Miyazaki, Tatsuya*; Oriuchi, Noboru*; Tominaga, Hideyuki*; Kanai, Yoshikatsu*; et al.

British Journal of Cancer, 110(8), p.1985 - 1991, 2014/04

 Times Cited Count:20 Percentile:58.79(Oncology)

Journal Articles

Quantitative analysis of cisplatin sensitivity of human esophageal squamous cancer cell lines using in-air micro-PIXE

Tanaka, Naritake*; Kimura, Hitoshi*; Faried, A.*; Sakai, Makoto*; Sano, Takaaki*; Inose, Takanori*; Soda, Makoto*; Okada, Koji*; Nakajima, Masanobu*; Miyazaki, Tatsuya*; et al.

Cancer Science, 101(6), p.1487 - 1492, 2010/06

 Times Cited Count:12 Percentile:33.54(Oncology)

We examined the intracellular localization of cisplatin, a key chemotherapeutic agent, in esophageal cancer cell lines and determined their sensitivity to cisplatin using in-air micro-PIXE. Two human esophageal squamous cell carcinoma (ESCC) cell lines, TE-2 and TE-13, were examined for their response to cisplatin using MTT assay, flow cytometry and DNA fragmentation assays. Real-time reverse transcription-polymerase chain reaction was also used to evaluate the mRNA expression of multidrug resistance protein 2 (MRP2) in both cell lines. Platinum localizations of intracellular and intranuclear were measured using in-air micro-PIXE. TE-2 cells were more sensitive to cisplatin than TE-13 cells. The results of this study suggest that in-air micro-PIXE could be a useful quantitative method for evaluating the cisplatin sensitivity of individual cells. Finally, we speculate that MRP2 in the cell membrane may play an important role in regulating cisplatin sensitivity of ESCC cells.

Journal Articles

Electron optical injection with head-on and countercrossing colliding laser pulses

Kotaki, Hideyuki; Daito, Izuru; Kando, Masaki; Hayashi, Yukio; Kawase, Keigo; Kameshima, Takashi*; Fukuda, Yuji; Homma, Takayuki; Ma, J.*; Chen, L. M.*; et al.

Physical Review Letters, 103(19), p.194803_1 - 194803_4, 2009/11

 Times Cited Count:54 Percentile:88.31(Physics, Multidisciplinary)

Journal Articles

Wide-$$q$$ observation from 10$$^{-4}$$ to 2.0$AA $^{-1}$$ using a focusing and polarized neutron small-angle scattering spectrometer, SANS-J-II

Iwase, Hiroki; Koizumi, Satoshi; Suzuki, Junichi; Oku, Takayuki; Sasao, Hajime*; Tanaka, Hirokazu*; Shimizu, Hirohiko*; Hashimoto, Takeji

Journal of Applied Crystallography, 40(s1), p.s414 - s417, 2007/04

 Times Cited Count:12 Percentile:76.72(Chemistry, Multidisciplinary)

In order to extend an upper q-limit larger, high-angle He sub-detectors were installed on focusing and polarized neutron small-angle scattering spectrometer (SANS-J-II) at JRR-3, Tokai. Consequently, its upper q-limit was improved from 0.2$AA $^{-1}$$ to 2$AA $^{-1}$$. To quantitatively discriminate spin incoherent scattering from hydrogen or to perform nuclear spin polarization contrast variation, a remanent supermirror analyser is also available on the high-angle sub detector. By combining a focusing ultra-small angle scattering, realized by compound and/or magnetic lens and high resolution area detector, SANS-J-II is able to cover from 3$$times$$10$$^{-3}$$ $AA $^{-1}$$ to 2$AA $^{-1}$$ (four order of magnitude of q), which profits to investigate hierarchically ordered system, found widely in hard, soft and bio-materials.

Journal Articles

A Magnetic neutron lens based on an extended Halbach-type permanent sextupole magnet

Oku, Takayuki; Yamada, Satoru; Sasao, Hajime*; Suzuki, Junichi; Shinohara, Takenao*; Hirota, Katsuya*; Ikeda, Kazuaki*; Tsuzaki, Tsuyoshi*; Kiyanagi, Yoshiaki*; Furusaka, Michihiro*; et al.

Physica B; Condensed Matter, 385-386(2), p.1225 - 1228, 2006/11

 Times Cited Count:10 Percentile:45.66(Physics, Condensed Matter)

We have developed a magnetic neutron lens based on an extended Halbach-type permanent sextupole magnet with magnet pieces of NEOMAX-44H, -35EH and high saturation magnetization material, permendule. The aperture size of the magnet is 35 mm in diameter and the magnet length is 2,400 mm. The magnet generates a sextupole magnetic field $$B_s=(C/2)r^2$$ with a gradient coefficient $$C$$=10,600 T/m$$^2$$ inside the aperture, where $$r$$ is a distance from the magnet center axis. To prevent neutrons from hitting and reflecting at the inner surface of the magnet, the surface is covered with cadmium (Cd) sheets and also Cd pinhole slits with size of 30 mm in diameter are positioned in series inside the magnet aperture, resulting in the effective diameter of 30 mm. The neutron focusing property of the magnet is investigated by using pulsed polarized neutrons. The obtained results are discussed with the precise simulation results. Its application to the focusing-geometry small-angle neutron scattering experiments is also discussed.

Journal Articles

Focusing and Polarized Neutron ultra-small-angle scattering spectrometer (SANS-J-II) at research reactor JRR3, Japan

Koizumi, Satoshi; Iwase, Hiroki; Suzuki, Junichi; Oku, Takayuki; Motokawa, Ryuhei; Sasao, Hajime*; Tanaka, Hirokazu; Yamaguchi, Daisuke; Shimizu, Hirohiko; Hashimoto, Takeji

Physica B; Condensed Matter, 385-386(2), p.1000 - 1006, 2006/11

 Times Cited Count:38 Percentile:81.15(Physics, Condensed Matter)

no abstracts in English

Journal Articles

A Demonstration study of focusing geometry SANS using a magnetic neutron lens

Oku, Takayuki; Suzuki, Junichi; Sasao, Hajime*; Yamada, Satoru; Furusaka, Michihiro*; Adachi, Tomohiro*; Shinohara, Takenao*; Ikeda, Kazuaki*; Shimizu, Hirohiko

Physica B; Condensed Matter, 356(1-4), p.126 - 130, 2005/02

 Times Cited Count:11 Percentile:46.44(Physics, Condensed Matter)

We have developed a magnetic neutron lens (MNL) based on a sextupole magnet. A neutron beam, which is incident to the sextupole magnet, either converges or diverges depending on the neutron spin state. Small-angle neutron scattering in focusing geometry (FSANS) was proposed to improve the q-resolution and/or measuring efficiency. The MNL is considered to be the most suitable focusing device for FSANS experiments using a polarized neutron beam, since it focuses the polarized neutron beam free from neutron attenuation and scattering by substances. Recently, we have developed the MNLs with sufficiently large apertures and strong focusing power for FSANS experiments. In this study, we evaluate the focusing property of the MNLs for the polarized neutron beam, and performed FSANS experiments using the MNL. The obtained results are discussed.

Journal Articles

Scenario to focusing polarized small-angle neutron scattering spectrometer SANS-J-II

Koizumi, Satoshi; Iwase, Hiroki; Tanaka, Hirokazu; Hashimoto, Takeji; Suzuki, Junichi; Oku, Takayuki; Sasao, Hajime*; Shimizu, Hirohiko

Hamon, 14(4), p.266 - 274, 2004/10

no abstracts in English

Journal Articles

Feasibility study on application of a magnetic neutron lens to SANS experiments

Oku, Takayuki; Suzuki, Junichi; Sasao, Hajime*; Adachi, Tomohiro*; Shinohara, Takenao*; Ikeda, Kazuaki*; Morishima, Takahiro*; Sakai, Kenji*; Kiyanagi, Yoshiaki*; Furusaka, Michihiro*; et al.

Nuclear Instruments and Methods in Physics Research A, 529(1-3), p.116 - 119, 2004/08

 Times Cited Count:18 Percentile:75.33(Instruments & Instrumentation)

As a neutron has a magnetic dipole moment, it is accelerated in a magnetic field gradient. Thus, we can control a neutron trajectory free from neutron beam attenuation and scattering using the magnetic field gradient. A sextupole magnetic field functions as a neutron focusing and defocusing lens depending on the neutron spin state. The neutron focusing effect was experimentally verified using a 6-piece permanent sextupole magnet. For the application in practical neutron scattering experiments, a sextupole magnet with a sufficiently large aperture accompanied with strong focusing power is demanded. Recently, a superconducting sextupole magnet, a Halbach-type permanent sextupole magnet and a sextupole pulse electro-magnet have been developed in a project of the development and application of neutron optics. These magnets will be dedicated to practical uses in neutron scattering experiments. In this paper, current status of the development of the magnetic neutron lenses is reported, and their application in the neutron scattering experiments is discussed.

JAEA Reports

Analysis on the fuel cycle requirements of the FR systems

Maki, Takashi*; Ichikawa, Hajime*; Asao, Takayuki*; Horiuchi, Nobutake*

JNC TJ9400 2002-004, 228 Pages, 2001/02

JNC-TJ9400-2002-004.PDF:9.97MB

We developed two computer codes to evaluate fuel cycle requirements of FR systems, which were selected in "the feasibility studies on commercialized FBR cycle systems". One code (CODE for material balance analysis) is to calculate the material balance data to evaluate the characteristics of each candidate. The other is to calculate the time-series data of material balance of fuel cycle as a whole, to evaluate an optimum scenario of FR systems introduction. The main characteristics of these codes are as follows: (1) Common function of both codes (a) They execute burn up calculation using characteristics values of reactor calculated with ORIGEN2 code. And they adjust Pu content using a concept of physical accounting method for adjusted fissile enrichment. (b) They simulate 18 type of FR systems, 10 reactor types and 6 reprocessing types. (2) Function of CODE for material balance analysis (a) It calculates nuclide inventory and thermal power, radioactivity, radio-toxicity in the waste and environmental release. (b) It evaluates safety of geological disposal of HLW and TRU waste (iodine waste) with simplified safety estimation method. (3) Function of CODE for time-series analysis (a) In addition to FR systems, it simulates 4 type of LWR systems and 5 type of Pu-Thermal LWR systems. (b)It calculates the Pu demand-and-supply situation. The precision of these codes was checked and verified by using other code result. Then we investigation characteristics of each FR system by evaluating material balance of fuel cycle. In addition we clarified differences between scenarios of introduction of FR systems.

JAEA Reports

Research on the reduction of environmental load

Maki, Takashi*; Asao, Takayuki*

JNC TJ9440 2000-012, 35 Pages, 2000/03

JNC-TJ9440-2000-012.pdf:2.08MB

Effects from the viewpoint of the reduction of environmental load have been evaluated in studies of the validity of the FBR fuel Cycle. As an index of environmental load, the dose rate, whish's caused by radionuclide migration from an underground repository to biosphere, is one of the most important items. For the evaluations of this dose rate, a simplified safety estimation method for the radioactive waste repository was developed. Furthermore, information related to index of environmental load was collected. And collected information was categorized and analyzed. Through this research, we got the following results. (1)A simplified safety estimation method for the radioactive waste repository that based on specified evaluation model and target nuclides was developed. Calculated results were compared to results of an existing safely estimation code, and were verified. (2)Though the most suitable item is varied with the goal and object of assessment, the most su㎜arized item that characterizes environmental load is "the volume of the waste".

Oral presentation

2D elemental analysis approach in focused neutron beam induced prompt $$gamma$$-ray analysis at JAEA

Segawa, Mariko; Matsue, Hideaki; Sekiya, Yuji*; Yamada, Satoru*; Shinohara, Takenao; Oku, Takayuki; Sasao, Hajime*; Suzuki, Junichi; Shimizu, Hirohiko

no journal, , 

Since neutron has the stronger penetration power than those for charged particles, the 2 dimensional prompt $$gamma$$-ray analysis method with use of neutron beam is the only way enables the nondestructive, isotopic and position dependent observation on small quantities of samples. Hence, we aimed at developing 2 dimensional prompt $$gamma$$-ray analysis systems in focused neutron beam at JAEA with a high resolution within a 1mm. A 2-demeinsinal analysis system is set at JRR-3 prompt $$gamma$$-ray system. The neutron beam is 0.6mm FWHM focused and collimated with use of a multichannel parabolic guide and a 6LiF collimator set at 90cm and 1.5 cm upstream with respect to the neutron beam from sample position, respectively. The sample could be stepping drive with 0.1mm. Finally, we succeed to increase the position resolution within 1mm, since we could split two neutron captured $$gamma$$-ray peaks from two minute Cd wire-sample, the diameter is 0.25mm$$phi$$ and the length is 5 mm, set at 1mm intervals.

Oral presentation

Evaluation of cisplatin localization in a cell and evaluation of sensitivity of esophageal cancer cell line

Tanaka, Naritake*; Sakai, Makoto*; Kimura, Hitoshi*; Soda, Makoto*; Nakajima, Masanobu*; Kato, Hiroyuki*; Asao, Takayuki*; Kuwano, Hiroyuki*; Oikawa, Masakazu*; Sato, Takahiro; et al.

no journal, , 

no abstracts in English

Oral presentation

Improvement of the stability of the laser accelerated electron beam by using colliding laser pulses

Kotaki, Hideyuki; Daito, Izuru; Kando, Masaki; Hayashi, Yukio; Kawase, Keigo; Kameshima, Takashi; Fukuda, Yuji; Homma, Takayuki; Ma, J.*; Chen, L. M.*; et al.

no journal, , 

no abstracts in English

Oral presentation

Improvement of the stability of laser accelerated electron bunch using counter-crossing and head-on laser pulses

Kotaki, Hideyuki; Daito, Izuru; Kando, Masaki; Hayashi, Yukio; Kawase, Keigo; Kameshima, Takashi; Fukuda, Yuji; Homma, Takayuki; Ma, J.*; Chen, L. M.*; et al.

no journal, , 

Oral presentation

Laser acceleration for stable electron beams at JAEA-APRC

Kotaki, Hideyuki; Kando, Masaki; Daito, Izuru; Hayashi, Yukio; Kawase, Keigo; Kameshima, Takashi*; Chen, L. M.*; Fukuda, Yuji; Homma, Takayuki; Esirkepov, T. Z.; et al.

no journal, , 

Oral presentation

Improvement of the laser-accelerated electron beam and its control

Kotaki, Hideyuki; Mori, Michiaki; Kando, Masaki; Hayashi, Yukio; Kawase, Keigo; Homma, Takayuki; Koga, J. K.; Daito, Izuru; Kameshima, Takashi*; Fukuda, Yuji; et al.

no journal, , 

no abstracts in English

Oral presentation

Clinical significance of l-type amino acid transporter 1 expression as a prognostic marker and potential of new targeting therapy in tongue cancer

Kaira, Kyoichi*; Toyoda, Minoru*; Ohshima, Yasuhiro; Oriuchi, Noboru*; Kanai, Yoshikatsu*; Oyama, Tetsunari*; Yamada, Masanobu*; Asao, Takayuki*; Chikamatsu, Kazuaki*

no journal, , 

18 (Records 1-18 displayed on this page)
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