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Journal Articles

Passive sweat collection and colorimetric analysis of biomarkers relevant to kidney disorders using a soft microfluidic system

Zhang, Y.*; Guo, H.*; Kim, S. B.*; Wu, Y.*; Ostojich, D.*; Park, S. H.*; Wang, X.*; Weng, Z.*; Li, R.*; Bandodkar, A. J.*; et al.

Lab on a Chip, 19(9), p.1545 - 1555, 2019/05

 Times Cited Count:11 Percentile:1.69(Biochemical Research Methods)

This paper introduces two important advances in recently reported classes of soft, skin-interfaced microfluidic systems for sweat capture and analysis: (1) a simple, broadly applicable means for collection of sweat that bypasses requirements for physical/mental exertion or pharmacological stimulation and (2) a set of enzymatic chemistries and colorimetric readout approaches for determining the concentrations of creatinine and urea in sweat, across physiologically relevant ranges. The results allow for routine, non-pharmacological capture of sweat across patient populations, such as infants and the elderly, that cannot be expected to sweat through exercise, and they create potential opportunities in the use of sweat for kidney disease screening/monitoring.

Journal Articles

Battery-free, skin-interfaced microfluidic/electronic systems for simultaneous electrochemical, colorimetric, and volumetric analysis of sweat

Bandodkar, A. J.*; Gutruf, P.*; Choi, J.*; Lee, K.-H.*; Sekine, Yurina; Reeder, J. T.*; Jeang, W. J.*; Aranyosi, A. J.*; Lee, S. P.*; Model, J. B.*; et al.

Science Advances (Internet), 5(1), p.eaav3294_1 - eaav3294_15, 2019/01

 Times Cited Count:60 Percentile:0.14(Multidisciplinary Sciences)

Interest in advanced wearable technologies increasingly extends beyond systems for biophysical measurements to those that enable continuous, non-invasive monitoring of biochemical markers in biofluids. Here, we introduce battery-free, wireless microelectronic platforms that perform sensing via schemes inspired by the operation of biofuel cells. Combining these systems in a magnetically releasable manner with chrono-sampling microfluidic networks that incorporate assays based on colorimetric sensing yields thin, flexible, lightweight, skin-interfaced technologies with broad functionality in sweat analysis. A demonstration device allows simultaneous monitoring of sweat rate/loss, along with quantitative measurements of pH and of lactate, glucose and chloride concentrations using biofuel cell and colorimetric approaches.

Journal Articles

Soft, skin-interfaced microfluidic systems with wireless, battery-free electronics for digital, real-time tracking of sweat loss and electrolyte composition

Kim, S. B.*; Lee, K.-H.*; Raj, M. S.*; Reeder, J. T.*; Koo, J.*; Hourlier-Fargette, A.*; Bandodkar, A. J.*; Won, S. M.*; Sekine, Yurina; Choi, J.*; et al.

Small, 14(45), p.1802876_1 - 1802876_9, 2018/11

 Times Cited Count:16 Percentile:11.46(Chemistry, Multidisciplinary)

Excretion of sweat from eccrine glands is a dynamic physiological process that varies with body position, activity level, and health status. Information content embodied in sweat rate and chemistry can be used to assess health status and athletic performance. This paper presents a thin, miniaturized, skin-interfaced microfluidic technology that includes a reusable, battery-free electronics module for measuring sweat conductivity and rate in real-time using wireless power from and data communication with capabilities in near field communications (NFC). Systematic studies of these combined microfluidic/electronic systems, accurate correlations of measurements performed with them to those of laboratory standard instrumentation, and field tests on human subjects establish the key operational features and their utility in sweat analytics.

Journal Articles

A Fluorometric skin-interfaced microfluidic device and smartphone imaging module for ${{it in situ}}$ quantitative analysis of sweat chemistry

Sekine, Yurina; Kim, S. B.*; Zhang, Y.*; Bandodkar, A. J.*; Xu, S.*; Choi, J.*; Irie, Masahiro*; Ray, T. R.*; Kohli, P.*; Kozai, Naofumi; et al.

Lab on a Chip, 18(15), p.2178 - 2186, 2018/08

The rich composition of solutes and metabolites in sweat and its relative ease of collection upon excretion from skin pores make this class of biofluid an attractive candidate for point of care analysis. Here, we present a complementary approach that exploits fluorometric sensing modalities integrated into a soft, skin-interfaced microfluidic system which, when paired with a simple smartphone-based imaging module, allows for in-situ measurement of important biomarkers in sweat. A network array of microchannels and a collection of microreservoirs pre-filled with fluorescent probes that selectively react with target analytes in sweat (e.g. probes), enable quantitative, rapid analysis. Field studies on human subjects demonstrate the ability to measure the concentrations of chloride, sodium and zinc in sweat, with accuracy that matches that of conventional laboratory techniques.

Journal Articles

Super-absorbent polymer valves and colorimetric chemistries for time-sequenced discrete sampling and chloride analysis of sweat via skin-mounted soft microfluidics

Kim, S. B.*; Zhang, Y.*; Won, S. M.*; Bandodkar, A. J.*; Sekine, Yurina; Xue, Y.*; Koo, J.*; Harshman, S. W.*; Martin, J. A.*; Park, J. M.*; et al.

Small, 14(12), p.1703334_1 - 1703334_11, 2018/03

 Times Cited Count:26 Percentile:5.63(Chemistry, Multidisciplinary)

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