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Journal Articles

Evaluation of photocatalytic abilities by variation of conductivity and dimethyl sulfoxide; Photocatalytically active TiO$$_{2}$$-coated wire mesh prepared via a double-layer coating method

Mori, Masanobu*; Sugita, Tsuyoshi; Fujii, Kengo*; Yamazaki, Taiki*; Isaka, Mayu*; Kobayashi, Kentaro*; Iwamoto, Shinji*; Itabashi, Hideyuki*

Analytical Sciences, 34(12), p.1449 - 1453, 2018/12

 Percentile:100(Chemistry, Analytical)

The photocatalyst coating stainless-steel wire mesh (TiO$$_{2}$$-WM) was prepared by double-layer coating method. The TiO$$_{2}$$-WM was evaluated using flow analytical system, which included the reactor and conductimetric detector (FAS-CD). The DMSO decomposition test through the FAS-CD reveal that photocatalytst was stable coating on the stainless-steel wire mesh.

Journal Articles

Recent progress of radiation physicochemical process (third part)

Kai, Takeshi; Yokoya, Akinari*; Fujii, Kentaro*; Watanabe, Ritsuko*

Hoshasen Kagaku (Internet), (106), p.21 - 29, 2018/11

It is thought to that the biological effects such as cell death or mutation are induced by complex DNA damage which are formed by several damage sites within a few nm. As the prediction of complex DNA damage at an electron track end, we report our outcomes. These results indicate that DNA damage sites comprising multiple nucleobase lesions with a single strand breaks can be formed by multiple collisions of the electrons within 1 nm. This multiple damage site cannot be processed by base excision repair enzymes. Pre-hydrated electrons can also be produced resulting in an additional base lesion over a few nm from the multi-damage site. This clustered damage site may be finally converted into a double strand break. These DSBs include another base lesion(s) at their termini that escape from the base excision process and which may result in biological effect. Our simulation is useful to reveal phenomena involved in radiation physico-chemistry as well as the DNA damage prediction.

Journal Articles

Enhanced aqueous adsorption and photodecomposition of anionic organic target by amino group-modified TiO$$_{2}$$ as anionic adsorptive photocatalyst

Sugita, Tsuyoshi; Kobayashi, Kenichi*; Kobayashi, Kentaro*; Yamazaki, Taiki*; Fujii, Kengo*; Itabashi, Hideyuki*; Mori, Masanobu*

Journal of Photochemistry and Photobiology A; Chemistry, 356, p.71 - 80, 2018/04

Photocatalysts shows high redox property only by light irradiation. However, the reaction performance is lowered in aqueous phase due to the low contact efficiency between catalyst and targets. In this study, to enhance aqueous adsorption and photodecomposition of anionic organic target, we developed an amino functional-based spacer (3-[2-(2- aminoethylamino)ethylamino]propyl-trimethoxysilane, DETA), and used it to modify TiO$$_{2}$$. The modified catalyst with positively charged amino groups could enhance the adsorption and photodecomposition of anionic organic targets.

Journal Articles

A Significant role of non-thermal equilibrated electrons in the formation of deleterious complex DNA damage

Kai, Takeshi; Yokoya, Akinari*; Ukai, Masatoshi*; Fujii, Kentaro*; Toigawa, Tomohiro; Watanabe, Ritsuko*

Physical Chemistry Chemical Physics, 20(4), p.2838 - 2844, 2018/01

 Times Cited Count:2 Percentile:37.68(Chemistry, Physical)

It is thought that complex DNA damage which induces in radiation biological effects is formed at radiation track end. Thus, the earliest stage of water radiolysis at the electron track end was studied to predict DNA damage. These results indicate that DNA damage sites comprising multiple nucleobase lesions with a single strand breaks can therefore be formed by multiple collisions of the electrons within three base pairs (3bp) of a DNA strand. This multiple damage site cannot be processed by base excision repair enzymes. However, pre-hydrated electrons can also be produced resulting in an additional base lesion more than 3bp away from the multi-damage site. This clustered damage site may be finally converted into a double strand break (DSB) when base excision enzymes process the additional base lesions. These DSBs include another base lesion(s) at their termini that escape from the base excision process and which may result in biological effects such as mutation in surviving cells.

Journal Articles

Reactivity of an antioxidant, edaravone, with reactive oxygen species and its chemical repair properties against oxidative damage on DNA

Hata, Kuniki; Lin, M.*; Yokoya, Akinari*; Fujii, Kentaro*; Yamashita, Shinichi*; Muroya, Yusa*; Katsumura, Yosuke*

Hoshasen Kagaku (Internet), (103), p.29 - 34, 2017/04

Reactivity of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), which is known to show high antioxidative properties, with oxidative species, such as hydroxyl radical ($${}^{bullet}$$OH) and azide radical (N$$^{bullet}$$$$_{3}$$), was investigated by a pulse radiolysis experiment, and generation behavior of edaravone radicals produced through these reactions were observed. It was shown that OH-adducts are produced by the reaction with $${}^{bullet}$$OH in contrast to the other oxidative radicals, which react with edaravone by an electron transfer reaction. Chemical repair properties of edaravone against DNA lesions produced by reactions of DNA with oxidative species were also investigated by a pulse radiolysis experiment with deoxyguanosine monophosphate (dGMP) and a $$gamma$$-radiolysis experiment with plasmid DNA solutions. It was observed that edaravone reduced dGMP radicals just after produced in a dilute aqueous solution and inhibited some base lesions on plasmid DNA more effectively than single strand breaks. These results show that edaravone may protect living system from oxidative stress, such as radiation, by not only scavenging oxidative species but also reducing precursors of DNA leisons.

Journal Articles

Dynamic behavior of secondary electrons produced by a high-energy electron in liquid water

Kai, Takeshi; Yokoya, Akinari*; Fujii, Kentaro*; Watanabe, Ritsuko*

Yodenshi Kagaku, (8), p.11 - 17, 2017/03

It is thought to that the biological effects such as cell death or mutation are induced by complex DNA damage which are formed by several damage sites within a few nm. We calculated dynamic behavior of secondary electrons produced by primary electron and positon of high energy in water whose composition ratio is similar to biological context. The secondary electrons induce the ionization or electronic excitation near the parent cations. The decelerated electrons about 10% are distributed to their parent cations by the attractive Coulombic force. From the results, we predicted the following formation mechanism for the complex DNA damage. The electrons ejected from DNA could induce the ionization or the electronic excitation within the DNA. The electrons attracted by the Coulombic force are pre-hydrated in water layer of the DNA. The pre-hydrated electrons could induce to the DNA damage by dissociative electron transfer. As the results, the complex DNA damage with 1 nm could be formed by the interaction of not only the primary electron or positon but also the secondary electrons.

Journal Articles

Deceleration processes of secondary electrons produced by a high-energy Auger electron in a biological context

Kai, Takeshi; Yokoya, Akinari; Ukai, Masatoshi; Fujii, Kentaro; Watanabe, Ritsuko

International Journal of Radiation Biology, 92(11), p.654 - 659, 2016/11

 Times Cited Count:1 Percentile:76.09(Biology)

Journal Articles

Dynamic behavior of secondary electrons in liquid water at the earliest stage upon irradiation; Implications for DNA damage localization mechanism

Kai, Takeshi; Yokoya, Akinari*; Ukai, Masatoshi*; Fujii, Kentaro*; Watanabe, Ritsuko*

Journal of Physical Chemistry A, 120(42), p.8228 - 8233, 2016/10

 Times Cited Count:2 Percentile:82.37(Chemistry, Physical)

Low energy secondary electrons produced by an ionizing radiation in a living cell may involve in formation of complexed DNA damage. We performed theoretical study for numerical calculation of dynamic behavior of the electrons to imply a formation of radiation damage to DNA. The decelerating electrons are gradually attracted to their parent cations by the Coulombic force within hundreds of fs, and about 12.6 % of electrons are finally distributed within 2 nm from the cations. The collision fraction of the ionization and excitation within 1 nm from the cation was estimated to be about 40 %. From those analyses, we suggested a process of DNA damage that the secondary electrons may cause highly localized lesions around a cation in DNA molecule through additional dissociative electron transfer as well as the ionization or the excitation if the electrons are ejected from DNA. The localized damage may involve ultimately in biological effects such as cell death or mutation induction.

Journal Articles

Recent progress of radiation physicochemical process (first part)

Kai, Takeshi; Yokoya, Akinari; Fujii, Kentaro; Watanabe, Ritsuko

Hoshasen Kagaku (Internet), (101), p.3 - 11, 2016/04

Behavior analysis of low energy electrons in liquid water provides the fundamentals for successive radiation chemistry, and it makes analysis of DNA damage implication involved in the electrons possible. We have progressed theoretical studies for radiation physicochemical process of liquid water to clear the role of low-energy secondary electrons damage to DNA. The process has included many unknown factors for the DNA damage so far. Based on the results, we implied a newly formation process of unrepair DNA damage produced by the secondary electrons assumed that it was ejected from DNA by impact of a high energy electron. We report our outcomes separately in three manuscripts entitled "Recent progress of radiation physicochemical process (first, second, third parts)" to journal of radiation chemistry. In this first part, we outline recent status of studies for the DNA damage and the radiation physicochemical process, we also show calculation method of electron impact cross sections involved strongly in electron deceleration in liquid water in the topics of our outcomes. From the calculated results, we also report our prediction, which are different from previous one, for electron thermalization.

Journal Articles

Ultraviolet circular dichroism spectroscopy for protein structural study

Izumi, Yudai; Yamamoto, Satoshi*; Fujii, Kentaro; Yokoya, Akinari

Hoshasen Seibutsu Kenkyu, 51(1), p.91 - 106, 2016/03

no abstracts in English

Journal Articles

Recent progress of radiation physicochemical process (second part)

Kai, Takeshi; Yokoya, Akinari*; Fujii, Kentaro*; Watanabe, Ritsuko*

Hoshasen Kagaku (Internet), (102), p.49 - 56, 2016/00

Behavior analysis of low energy electrons in liquid water provides the fundamentals for successive radiation chemistry, and it makes analysis of DNA damage implication involved in the electrons possible. We have progressed theoretical studies for radiation physicochemical process of water to clear the role of secondary electrons damage to DNA. The process has included many unknown factors for the DNA damage so far. We implied a newly formation process of unrepair DNA damage produced by the secondary electrons. We report our outcomes separately in three manuscripts entitled "Recent progress of radiation physicochemical process (first, second, third parts)". In this second part, we show calculated results of thermalization lengths and times of electrons in water to verify a dynamic Monte Carlo code developed in this study. From the calculated results, we also report our prediction, which are different from previous one, for thermalization and pre-hydration processes.

Journal Articles

Investigation of the fragmentation of core-ionised deoxyribose; A Study as a function of the tautomeric form

Herv$'e$ du Penhoat, M.-A.*; Kamol Ghose, K.*; Gaigeot, M.-P.*; Vuilleumier, R.*; Fujii, Kentaro; Yokoya, Akinari; Politis, M.-F.*

Physical Chemistry Chemical Physics, 17(48), p.32375 - 32383, 2015/12

 Times Cited Count:4 Percentile:70.81(Chemistry, Physical)

Journal Articles

Secondary structure alterations of histones H2A and H2B in X-irradiated human cancer cells; Altered histones persist in cells for at least 24 hours

Izumi, Yudai; Yamamoto, Satoshi*; Fujii, Kentaro; Yokoya, Akinari

Radiation Research, 184(5), p.554 - 558, 2015/11

 Times Cited Count:4 Percentile:59.33(Biology)

Journal Articles

Thermal equilibrium and prehydration processes of electrons injected into liquid water calculated by dynamic Monte Carlo method

Kai, Takeshi; Yokoya, Akinari; Ukai, Masatoshi*; Fujii, Kentaro; Watanabe, Ritsuko

Radiation Physics and Chemistry, 115, p.1 - 5, 2015/10

 Times Cited Count:7 Percentile:22.72(Chemistry, Physical)

Role of secondary electrons on DNA damage have not been understood sufficiently because there still exists a lack of study for thermalization process of an electron in liquid phase. We calculated thermalization lengths and spatial distributions of an electron in liquid water using cross sections for rotation and phonon excitations in a liquid phase. Obtained thermalization lengths are in good agreement with experimental results reported by literatures. Thermalization time was also estimated from time evolution of spatial distributions of the incident electron to be hundreds femtoseconds. From these results, we predict that thermalization and pre-hydration of electron might progress simultaneously. These electrons possibly cause damage in biological molecules in a cell. Particularly severe types of DNA damage consisting of proximately located multiple lesions are potentially induced by reaction of DNA with the thermalized electrons by dissociative electron transfer.

Journal Articles

Live-cell imaging study of mitochondrial morphology in mammalian cells exposed to X-rays

Noguchi, Miho; Kanari, Yukiko; Yokoya, Akinari; Narita, Ayumi; Fujii, Kentaro

Radiation Protection Dosimetry, 166(1-4), p.101 - 103, 2015/09

 Percentile:100(Environmental Sciences)

Journal Articles

Real-time observation of irradiated HeLa-cell modified by fluorescent ubiquitination-based cell-cycle indicator using synchrotron X-ray microbeam

Narita, Ayumi; Kaminaga, Kiichi; Yokoya, Akinari; Noguchi, Miho; Kobayashi, Katsumi*; Usami, Noriko*; Fujii, Kentaro

Radiation Protection Dosimetry, 166(1-4), p.192 - 196, 2015/09

 Times Cited Count:2 Percentile:66.76(Environmental Sciences)

For the knowledge about irradiation effects of mammalian cells depending on the cell cycle, most of them had been analyzed by statistical approches. Our purpose is to establish the method for real-time observation of irradiated cells under a microscope. Fluorescent ubiquitination-based cell cycle indicator (FUCCI) human cancer (HeLa) cells (red indicates G1; green, S/G2) were exposed to a synchrotron X-ray microbeam. Cells in either G1 or S/G2 were selectively irradiated according to cell color observed in the same microscopic field in a culture dish. Time-lapse micrographs of the irradiated cells were acquired for 24 h after irradiation. The cell cycle was strongly arrested by irradiation at S/G2 and never progressed to G1. In contrast, cells irradiated at G1 progress to S/G2 with a similar time course as non-irradiated control cells. These results show single FUCCI cell exposure and live cell imaging are powerful methods for studying radiation effects on the cell cycle.

Journal Articles

Nitrogen K-edge X-ray absorption near edge structure of pyrimidine-containing nucleotides in aqueous solution

Shimada, Hiroyuki*; Minami, Hirotake*; Okuizumi, Naoto*; Sakuma, Ichiro*; Ukai, Masatoshi*; Fujii, Kentaro; Yokoya, Akinari; Fukuda, Yoshihiro*; Saito, Yuji

Journal of Chemical Physics, 142(17), p.175102_1 - 175102_9, 2015/05

AA2015-0073.pdf:1.15MB

 Times Cited Count:5 Percentile:63.57(Chemistry, Physical)

Journal Articles

Dynamics of low-energy electrons in liquid water with consideration of Coulomb interaction with positively charged water molecules induced by electron collision

Kai, Takeshi; Yokoya, Akinari; Ukai, Masatoshi*; Fujii, Kentaro; Higuchi, Mariko; Watanabe, Ritsuko

Radiation Physics and Chemistry, 102, p.16 - 22, 2014/09

 Times Cited Count:10 Percentile:18.68(Chemistry, Physical)

no abstracts in English

Journal Articles

Nitrogen K-edge X-ray absorption near edge structure (XANES) spectra of purine-containing nucleotides in aqueous solution

Shimada, Hiroyuki*; Fukao, Taishi*; Minami, Hirotake*; Ukai, Masatoshi*; Fujii, Kentaro; Yokoya, Akinari; Fukuda, Yoshihiro*; Saito, Yuji

Journal of Chemical Physics, 141(5), p.055102_1 - 055102_8, 2014/08

 Times Cited Count:6 Percentile:63.92(Chemistry, Physical)

Journal Articles

Cross section measurements of the radioactive $$^{107}$$Pd and stable $$^{105,108}$$Pd nuclei at J-PARC/MLF/ANNRI

Nakamura, Shoji; Kimura, Atsushi; Kitatani, Fumito; Ota, Masayuki; Furutaka, Kazuyoshi; Goko, Shinji*; Hara, Kaoru; Harada, Hideo; Hirose, Kentaro; Kin, Tadahiro*; et al.

Nuclear Data Sheets, 119, p.143 - 146, 2014/05

 Times Cited Count:4 Percentile:55.88(Physics, Nuclear)

We have started the measurements of the neutron-capture cross sections for stable $$^{105,108}$$Pd nuclei as well as the radioactive $$^{107}$$Pd. The neutron-capture cross-section measurements by the time-of flight method were performed using an apparatus called "Accurate Neutron-Nucleus Reaction measurement Instrument (ANNRI)" installed at the neutron Beam Line No.4 of the Materials and Life science experimental Facility (MLF) in the J-PARC. The neutron-capture cross sections of $$^{107}$$Pd and $$^{105,108}$$Pd have been measured in the neutron energy range from thermal to 300 eV. Some new information was obtained for resonances of these Pd nuclei.

208 (Records 1-20 displayed on this page)