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Journal Articles

Tumor radioresistance caused by radiation-induced changes of stem-like cell content and sub-lethal damage repair capability

Fukui, Roman*; Saga, Ryo*; Matsuya, Yusuke; Tomita, Kazuo*; Kuwahara, Yoshikazu*; Ouchi, Kentaro*; Sato, Tomoaki*; Okumura, Kazuhiko*; Date, Hiroyuki*; Fukumoto, Manabu*; et al.

Scientific Reports (Internet), 12(1), p.1056_1 - 1056_12, 2022/01

 Times Cited Count:1 Percentile:79.81(Multidisciplinary Sciences)

Alive cancer cells after fractionated irradiations with 2 Gy X-rays per day for more than 30 days show clinically relevant radioresistant. Such radioresistance is experimentally interpreted to attributed to the increment of stem-like cell content. However, only an experimental approach cannot clarify the cell responses (DNA damage and cell death induction) of cancer stem cells, so the radioresistant mechanisms remain uncertain. In addition to the conventional cell experiments using radio-resistant cell lines established after fractionated irradiations, in this study we developed a mathematical model (so called integrated microdosimetric-kinetic (IMK) model) explicitly considering cancer stem-like cell content and DNA damage responses and investigated radioresistant mechanisms acquired after fractionated irradiations. The IMK model analysis suggested that the changes of stem-like cell fraction and DNA repair efficiency play important roles of radioresisitance acquired after irradiations. Considering these into the IMK model, we successfully reproduced the experimental survival of various cell lines and various irradiation conditions. This work would contribute to not only the precise understanding of the radioresistant mechanisms induced after irradiation but also predicting curative effects with high precision.

Journal Articles

A 3 MeV linac for development of accelerator components at J-PARC

Kondo, Yasuhiro; Asano, Hiroyuki*; Chishiro, Etsuji; Hirano, Koichiro; Ishiyama, Tatsuya; Ito, Takashi; Kawane, Yusuke; Kikuzawa, Nobuhiro; Meigo, Shinichiro; Miura, Akihiko; et al.

Proceedings of 28th International Linear Accelerator Conference (LINAC 2016) (Internet), p.298 - 300, 2017/05

We have constructed a linac for development of various accelerator components at J-PARC. The ion source is same as the J-PARC linac's, and the RFQ is a used one in the J-PARC linac. The beam energy is 3 MeV and nominal beam current is 30 mA. The accelerator has been already commissioned, and the first development program, laser-charge-exchange experiment for the transmutation experimental facility, has been started. In this paper, present status of this 3-MeV linac is presented.

Journal Articles

Development of beam scrapers using a 3-Mev linac at J-PARC

Hirano, Koichiro; Asano, Hiroyuki; Ishiyama, Tatsuya; Ito, Takashi; Okoshi, Kiyonori; Oguri, Hidetomo; Kondo, Yasuhiro; Kawane, Yusuke; Kikuzawa, Nobuhiro; Sato, Yoshikatsu; et al.

Proceedings of 13th Annual Meeting of Particle Accelerator Society of Japan (Internet), p.310 - 313, 2016/11

We have used a beam scraper with the incident angle of 65deg to reduce the beam power deposition density in the MEBT between a 324 MHz RFQ and a 50-MeV DTL of the J-PARC linac. The 65$$^{circ}$$ scraper was irradiated by the H$$^{-}$$ beam up to particle number of 1.47E22. We observed a lot of surface projections with several hundred micrometers high in the beam irradiation damage on the scraper by using the laser microscope. In order to study the limits of scrapers, we constructed a new 3 MeV linac at J-PARC. We will conduct the scraper irradiation test at the end of this year.

JAEA Reports

Study on crystalline rock aiming at evaluation method of long-term behavior of rock mass; FY2013 (Contract research)

Fukui, Katsunori*; Hashiba, Kimihiro*; Sato, Toshinori; Sanada, Hiroyuki; Kuwabara, Kazumichi

JAEA-Research 2014-020, 50 Pages, 2014/11

JAEA-Research-2014-020.pdf:2.8MB

On the radioactive waste disposal, the long-term mechanical stability of shafts and galleries excavated in rock is required. Therefore, it is very important to understand the time-dependent behavior of rock mass for evaluating long-term mechanical stability. The purpose of this study is determining the mechanisms of time-dependent behavior of rock mass by precise testing, observation and measurement in order to develop methods for evaluating long-term mechanical stability of a rock mass. This report describes the results of the activities in fiscal year 2013. In Chapter 1, we described the overview and background of this study. In Chapter 2, the results of a long-term creep test on Tage tuff, started in fiscal year 1997 are described. In Chapter 3, the result of organization and analysis for time-dependent behavior of crystalline rock was described. In Chapter 4, for the drafting of in-situ test plan, examination of the numerical analysis technique of rock mass was carried out.

Journal Articles

Present status of J-PARC linac

Oguri, Hidetomo; Hasegawa, Kazuo; Ito, Takashi; Chishiro, Etsuji; Hirano, Koichiro; Morishita, Takatoshi; Shinozaki, Shinichi; Ao, Hiroyuki; Okoshi, Kiyonori; Kondo, Yasuhiro; et al.

Proceedings of 11th Annual Meeting of Particle Accelerator Society of Japan (Internet), p.389 - 393, 2014/10

no abstracts in English

JAEA Reports

Study on crystalline rock for evaluating method of long-term behavior; FY2012 (Contract research)

Fukui, Katsunori*; Hashiba, Kimihiro*; Tanno, Takeo; Hikima, Ryoichi; Sanada, Hiroyuki; Sato, Toshinori

JAEA-Research 2013-031, 52 Pages, 2013/12

JAEA-Research-2013-031.pdf:4.06MB

It is very important to understand the time-dependent behavior of rock for evaluating long-term mechanical stability. The purpose of this study is determining the mechanisms of time-dependent behavior of rock by the precise test, observation and measurement, to develop methods for evaluating long-term mechanical stability. This report describes the results of the activities in fiscal year 2012. In Chapter 1, we provide an overview and the background to this study. In Chapter 2, the results of a long-term creep test on Tage tuff, started in fiscal year 1997 are described. In Chapter 3, the experimental results concerning the loading-rate dependency of strength were examined to understand the time-dependency of rock. In Chapter 4, the stability of tunnels, around which rock stress is larger than that around a circular tunnel, were examined to obtain useful information on the future plan for ${it in-situ}$ tests in the underground research laboratory.

Journal Articles

RF control system for the RFQ test station at J-PARC linac

Fukui, Yuji*; Kawamura, Masato*; Kobayashi, Tetsuya*; Fang, Z.*; Futatsukawa, Kenta*; Sato, Fumiaki; Shinozaki, Shinichi; Suzuki, Hiroyuki; Chishiro, Etsuji; Hori, Toshihiko; et al.

Proceedings of 9th Annual Meeting of Particle Accelerator Society of Japan (Internet), p.762 - 764, 2013/08

no abstracts in English

JAEA Reports

Phenomenological study on crystalline rock for evaluating of long-term behavior (Contract research)

Okubo, Seisuke*; Fukui, Katsunori*; Hashiba, Kimihiro*; Hikima, Ryoichi; Tanno, Takeo; Sanada, Hiroyuki; Matsui, Hiroya; Sato, Toshinori

JAEA-Research 2011-040, 54 Pages, 2012/02

JAEA-Research-2011-040.pdf:2.85MB

With respect to high-level radioactive waste disposal, knowledge of the long-term mechanical stability of shafts and galleries excavated in rock are required, not only during construction and operation but also over a period of thousands of years after closure. Therefore, it is very important to understand the time-dependent behavior of rock for evaluating long-term mechanical stability. This report describes the results of the activities in FY2010. In Chapter 1, we provide an overview and the background to this study. In Chapter 2, the results of a long-term creep test on Tage tuff, started in FY1997 are described. In Chapter 3, the relation of loading-rate dependency of strength and stress dependency of creep life, the relationship of time dependency and probability distribution of strength or creep life and size effects are discussed to indicate more clearly the meaning of the value of "n" to express the degree of time dependency of the rock. In Chapter 4, failure criterions of a rock mass considering time dependency are discussed. In Chapter 5, the FEM analysis implemented with a generalized variable-compliance-type constitutive equation considering the change of "n" in confining pressure and strength distribution of rock mass carried out to clarify the long-term behavior of Toki granite is described. Finally, based on the numerical analysis, an in situ testing method is proposed.

Journal Articles

Power supply system for klystron in J-PARC linac

Kawamura, Masato*; Fukui, Yuji*; Naito, Fujio*; Chishiro, Etsuji; Yamazaki, Masayoshi*; Suzuki, Hiroyuki*; Shinozaki, Shinichi; Hasegawa, Kazuo

Proceedings of 25th International Linear Accelerator Conference (LINAC 2010) (CD-ROM), p.887 - 889, 2010/09

This paper describes the present status, technical specifications, operating experience, and upgrade plane for the power supply system (PS system) for the klystrons in the J-PARC. The PS systems include both the high voltage DC power supplies (DCPSs), which drives one or four modulating-anode klystron each, and the anode-modulators, one per klystron. Currently, the energy output of the J-PARC linac is 181 MeV, which includes the energy necessary to run twenty 324 MHz klystrons. In 2012, the linac will add twenty-five 972 MHz klystrons and upgrade the energy output to 400 MeV.

Journal Articles

Development of LLRF control software for the J-PARC 400 MeV Linac

Fang, Z.*; Michizono, Shinichiro*; Anami, Shozo*; Yamaguchi, Seiya*; Naito, Fujio*; Fukui, Yuji*; Kobayashi, Tetsuya; Suzuki, Hiroyuki; Chishiro, Etsuji; Shinozaki, Shinichi

Proceedings of 7th Annual Meeting of Particle Accelerator Society of Japan (DVD-ROM), p.1068 - 1070, 2010/08

The output energy of the J-PARC proton Linac will be upgraded from 181 to 400 MeV in the next two years by adding 972-MHz high-beta acceleration sections. The RF signals are controlled by the FPGA-based digital feedback control systems installed in a compact PCI (cPCI). Recently, the LLRF control software has also been upgraded for the J-PARC Linac, especially for the 972-MHz high-beta systems. Many functions have been added to the LLRF control software, such as (1) gradually increasing the feedback gains in the feedback loop instead of fixed ones, (2) automatic chopped-beam compensation, (3) automatically switching the beam loading compensation in accordance with the different beam operation mode, (4) input RF-frequency tuning carried out by a FPGA to match the RF cavities during the RF start-up, (5) auto-tuning of the RF cavity tuner by detecting the phase curve of the RF cavity during the field decay instead of the phase difference between the cavity input and output signals.

Journal Articles

LLRF controller upgrade for the J-PARC 400 MeV linac

Fang, Z.*; Michizono, Shinichiro*; Anami, Shozo*; Yamaguchi, Seiya*; Naito, Fujio*; Fukui, Yuji*; Kawamura, Masato*; Kubota, Chikashi*; Nammo, Kesao*; Kobayashi, Tetsuya; et al.

Proceedings of 1st International Particle Accelerator Conference (IPAC '10) (Internet), p.1434 - 1436, 2010/05

The output energy of the J-PARC proton linac will be upgraded from 181 to 400 MeV in the next two years by adding high-b acceleration sections. The upgrade of the FPGA-based digital LLRF controller for the 400 MeV linac will be presented in this paper. This new LLRF controller works for both the 324-MHz low-b and 972-MHz high-b sections. Many functions have been added into the LLRF controller, such as (1) working for different RF systems, (2) gradually increasing the feedback gains in the feedback loop instead of fixed ones, (3) automatic chopped beam compensation, (4) automatically switching the beam loading compensation in accordance with different beam operation mode, (5) input RF-frequency tuning to match the RF cavities during RF start-up, and (6) auto-tuning of the RF cavity tuner by detecting the phase curve of the RF cavity during the field decay instead of the phase difference between the cavity input and output signals.

Journal Articles

Structure of liquid water under high pressure up to 17 GPa

Katayama, Yoshinori; Hattori, Takanori; Saito, Hiroyuki; Ikeda, Takashi; Aoki, Katsutoshi; Fukui, Hiroshi*; Funakoshi, Kenichi*

Physical Review B, 81(1), p.014109_1 - 014109_6, 2010/01

 Times Cited Count:64 Percentile:89.95(Materials Science, Multidisciplinary)

The structure of liquid water was studied along the melting curve up to 17.1 GPa and 850 K by in situ X-ray diffraction. At low pressures, the local structure changed toward a simple liquid-like structure through an increase in the coordination number of water molecules. Once densely packed structure of water molecules was achieved around 4 GPa, the volume was reduced through the decrease of the intermolecular distance on further compression. Classical molecular dynamics simulations well reproduced the experimental results although the degree of agreement depended on pressure. Limitations of the pair potential model were discussed.

Journal Articles

Operating experience of the J-PARC linac

Hasegawa, Kazuo; Asano, Hiroyuki; Chishiro, Etsuji; Hori, Toshihiko; Ito, Takashi; Kobayashi, Tetsuya; Kondo, Yasuhiro; Namekawa, Yuya; Oguri, Hidetomo; Okoshi, Kiyonori; et al.

Proceedings of 24th International Linear Accelerator Conference (LINAC 2008) (CD-ROM), p.55 - 57, 2009/00

The beam commissioning of the J-PARC linac started in November 2006 and 181 MeV acceleration was successfully achieved in January 2007. The linac has delivered beams to the 3 GeV Rapid Cycling Synchrotron for its commissioning, and then, the subsequent Main Ring Synchrotron and the neutron target commissioning. The linac uses a Cs-free LaB$$_{6}$$-driven ion source and 20 units of 324 MHz klystrons. As of June 2008, the operation times are about 3,000 and 6,000 hours for the ion source and the RF source, respectively. The operating experience of the linac is described.

Journal Articles

Present status of RF source operation at J-PARC linac

Yamazaki, Masayoshi; Chishiro, Etsuji; Kobayashi, Tetsuya; Hori, Toshihiko; Suzuki, Hiroyuki; Anami, Shozo*; Kawamura, Masato*; Fukui, Yuji*; Nammo, Kesao*; Fang, Z.*; et al.

Proceedings of 5th Annual Meeting of Particle Accelerator Society of Japan and 33rd Linear Accelerator Meeting in Japan (CD-ROM), p.485 - 487, 2008/00

no abstracts in English

Journal Articles

DATA collection using memory area of PLC touch panel for J-PARC linac RF

Suzuki, Hiroyuki; Chishiro, Etsuji; Kobayashi, Tetsuya; Hori, Toshihiko; Yamazaki, Masayoshi; Anami, Shozo*; Yamaguchi, Seiya*; Kawamura, Masato*; Fukui, Yuji*; Fang, Z.*

Proceedings of 5th Annual Meeting of Particle Accelerator Society of Japan and 33rd Linear Accelerator Meeting in Japan (CD-ROM), p.467 - 469, 2008/00

no abstracts in English

Journal Articles

Performance of J-PARC linac RF system

Kobayashi, Tetsuya; Chishiro, Etsuji; Hori, Toshihiko; Suzuki, Hiroyuki; Yamazaki, Masayoshi; Anami, Shozo*; Fang, Z.*; Fukui, Yuji*; Kawamura, Masato*; Michizono, Shinichiro*; et al.

Proceedings of 2007 Particle Accelerator Conference (PAC '07) (Internet), p.2128 - 2130, 2007/08

High power operation of all the RF systems of J-PARC linac was started for the cavity conditioning in October 2006. Twenty 324-MHz klystrons have supplied the power to the accelerating cavities successfully, and the beam commissioning was started in November 2006. The RF drive and control systems are working well, and required stability is satisfied.

Journal Articles

Confinement of microwave in RF equipment of J-PARC linac

Chishiro, Etsuji; Kobayashi, Tetsuya; Suzuki, Hiroyuki; Yamazaki, Masayoshi; Hori, Toshihiko; Fang, Z.*; Fukui, Yuji*; Kawamura, Masato*; Yamaguchi, Seiya*; Anami, Shozo*

Proceedings of 4th Annual Meeting of Particle Accelerator Society of Japan and 32nd Linear Accelerator Meeting in Japan (CD-ROM), p.519 - 521, 2007/00

High power RF sources have been installed in J-PARC linac building. The RF source is defined as the microwave application equipment by the Radio low, and is needed the charge minister's permission to offer the service. To pass the regulation, we sought the leakage point using a search coil and a bilog antenna, and stopped up the leak by contacting the metal connection completely. The result of measuring the microwave at the J-PARC site boundary, we confirmed the field strength which is less than permissible level.

Journal Articles

Present status of RF source operation at J-PARC LINAC

Yamazaki, Masayoshi; Chishiro, Etsuji; Kobayashi, Tetsuya; Hori, Toshihiko; Suzuki, Hiroyuki; Anami, Shozo*; Kawamura, Masato*; Fukui, Yuji*; Nammo, Kesao*; Fang, Z.*; et al.

Proceedings of 4th Annual Meeting of Particle Accelerator Society of Japan and 32nd Linear Accelerator Meeting in Japan (CD-ROM), p.516 - 518, 2007/00

no abstracts in English

Journal Articles

Performance of J-PARC LINAC RF system

Kobayashi, Tetsuya; Chishiro, Etsuji; Hori, Toshihiko; Suzuki, Hiroyuki; Yamazaki, Masayoshi; Anami, Shozo*; Fang, Z.*; Fukui, Yuji*; Kawamura, Masato*; Michizono, Shinichiro*; et al.

Proceedings of 4th Annual Meeting of Particle Accelerator Society of Japan and 32nd Linear Accelerator Meeting in Japan (CD-ROM), p.510 - 512, 2007/00

High power operation of all the RF systems of J-PARC linac was started for the cavity conditioning in October 2006. Twenty 324-MHz klystrons have supplied the power to the accelerating cavities successfully. The beam commissioning was started in November 2006 then the acceleration to the design energy of 181 MeV was succeeded. The injection to the 3-GeV synchrotron will be started in September 2007. The RF control systems are performing according to the expectation, and the required field stability is satisfied.

Journal Articles

PLC control of J-PARC low level RF system

Suzuki, Hiroyuki; Chishiro, Etsuji; Ito, Takashi; Kobayashi, Tetsuya; Hasegawa, Kazuo; Anami, Shozo*; Yamaguchi, Seiya*; Michizono, Shinichiro*; Fang, Z.*; Naito, Fujio*; et al.

Proceedings of 4th Annual Meeting of Particle Accelerator Society of Japan and 32nd Linear Accelerator Meeting in Japan (CD-ROM), p.513 - 515, 2007/00

no abstracts in English

46 (Records 1-20 displayed on this page)