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Fukui, Roman*; Saga, Ryo*; Matsuya, Yusuke; Tomita, Kazuo*; Kuwahara, Yoshikazu*; Ouchi, Kentaro*; Sato, Tomoaki*; Okumura, Kazuhiko*; Date, Hiroyuki*; Fukumoto, Manabu*; et al.
Scientific Reports (Internet), 12(1), p.1056_1 - 1056_12, 2022/01
Times Cited Count：10 Percentile：91.34(Multidisciplinary Sciences)Alive cancer cells after fractionated irradiations with 2 Gy X-rays per day for more than 30 days show clinically relevant radioresistant. Such radioresistance is experimentally interpreted to attributed to the increment of stem-like cell content. However, only an experimental approach cannot clarify the cell responses (DNA damage and cell death induction) of cancer stem cells, so the radioresistant mechanisms remain uncertain. In addition to the conventional cell experiments using radio-resistant cell lines established after fractionated irradiations, in this study we developed a mathematical model (so called integrated microdosimetric-kinetic (IMK) model) explicitly considering cancer stem-like cell content and DNA damage responses and investigated radioresistant mechanisms acquired after fractionated irradiations. The IMK model analysis suggested that the changes of stem-like cell fraction and DNA repair efficiency play important roles of radioresisitance acquired after irradiations. Considering these into the IMK model, we successfully reproduced the experimental survival of various cell lines and various irradiation conditions. This work would contribute to not only the precise understanding of the radioresistant mechanisms induced after irradiation but also predicting curative effects with high precision.
Sasaki, Koei; Miura, Shuichiro*; Fukumoto, Kenichi*; Goto, Minoru; Ohashi, Hirofumi
Proceedings of 28th International Conference on Nuclear Engineering (ICONE 28) (Internet), 6 Pages, 2021/08
Cs-Bi and Cs-Sb absorbed graphite samples (Cs-Bi/graphite and Cs-Sb/graphite) were synthesized and their high temperature chemical stabilities were tested up to 1500
C by TG and analyzed by TEM-EDS for the development of Cs trap material in high temperature gas-cooled reactor (HTGR) fuel particles. It was observed that Cs was stabilized by Sb but not by Bi in the specimens after the TG test. A rapid weight loss from 800 to 1000C may be caused by evaporation of Cs (boiling point: 671C) was seen in the TG result of both specimens. Precipitated Cs-Sb substance in the graphite matrix were not resolved even after the 1500C heating. The chemical composition of the Cs-Sb was specified as Cs
Sb. The experimental results suggest that Sb have potential to be a Cs getter material in graphite matrix. Long term heating test should be performed to confirm adaptability of Sb for Cs trap material in HTGR fuel particles.
Nakashima, Yosuke*; Takeda, Hisahito*; Ichimura, Kazuya*; Hosoi, Katsuhiro*; Oki, Kensuke*; Sakamoto, Mizuki*; Hirata, Mafumi*; Ichimura, Makoto*; Ikezoe, Ryuya*; Imai, Tsuyoshi*; et al.
Journal of Nuclear Materials, 463, p.537 - 540, 2015/08
Times Cited Count：19 Percentile：82.55(Materials Science, Multidisciplinary)Nakashima, Yosuke*; Sakamoto, Mizuki*; Yoshikawa, Masayuki*; Oki, Kensuke*; Takeda, Hisahito*; Ichimura, Kazuya*; Hosoi, Katsuhiro*; Hirata, Mafumi*; Ichimura, Makoto*; Ikezoe, Ryuya*; et al.
Proceedings of 25th IAEA Fusion Energy Conference (FEC 2014) (CD-ROM), 8 Pages, 2014/10
Kanamori, Masashi; Hashimoto, Kazuichiro; Terunuma, Hiroshi; Ikeda, Takeshi; Omura, Akiko; Terakado, Naoya; Nagakura, Tomohiro; Fukumoto, Masahiro; Watanabe, Fumitaka; Yamamoto, Kazuya; et al.
JAEA-Review 2009-023, 61 Pages, 2009/09
JAEA-Review-2009-023.pdf:8.49MB
When a nuclear emergency occurs in Japan, the Japan Atomic Energy Agency (JAEA) provides technical support to the National government, local governments, police, fire station and license holder etc. They are Designated Public Organizations conforming to the Basic Law on Emergency Preparedness and the Basic Plan for Disaster Countermeasures. The Nuclear Emergency Assistance and Training Center (NEAT) of JAEA provides a comprehensive range of technical support activities to an Off-Site Center in case of a nuclear emergency. Specifically, NEAT gives technical advice and information, provides for the dispatch of specialist as required, supplies emergency equipments and materials to the Joint Council of Nuclear Disaster Countermeasures, which meets at the Off-Site Center. NEAT provide various lectures and training course concerning nuclear disaster prevention for those personnel taking an active part in emergency response organizations at normal time. And NEAT researches on nuclear disaster prevention and also cooperate with international organizations. This annual report summarized the activities of JAEA/NEAT in the fiscal year 2008.
Auguste, T.*; Faenov, A. Y.*; Fukumoto, Ichiro; Hulin, S.*; Magunov, A. I.*; Monot, P.*; D'Oliveira, P.*; Pikuz, T. A.*; Sasaki, Akira; Sharkov, B. Y.*; et al.
Journal of Quantitative Spectroscopy & Radiative Transfer, 71(2-6), p.147 - 156, 2001/10
Times Cited Count：14 Percentile：57.94(Optics)no abstracts in English
Zhidkov, A. G.; Sasaki, Akira; Fukumoto, Ichiro; Tajima, Toshiki; Auguste, T.*; D'Oliveira, P.*; Hulin, S.*; Monot, P.*; Faenov, A. Y.*; Pikuz, T. A.*; et al.
Physics of Plasmas, 8(8), p.3718 - 3723, 2001/08
Times Cited Count：44 Percentile：76.96(Physics, Fluids & Plasmas)no abstracts in English
Fukumoto, Ichiro; Omura, Etsuji*
Seimitsu Kogakkai-Shi, 67(6), p.916 - 921, 2001/06
no abstracts in English
Zhidkov, A. G.; Sasaki, Akira; Utsumi, Takayuki*; Fukumoto, Ichiro; Tajima, Toshiki; Saito, Fumikazu*; Hironaka, Yoichiro*; Nakamura, Kazutaka*; Kondo, Kenichi*; Yoshida, Masataka*
Physical Review E, 62(5), p.7232 - 7240, 2000/11
Times Cited Count：51 Percentile：85.94(Physics, Fluids & Plasmas)no abstracts in English
Fukumoto, Kenichi*; Matsui, Hideki*; Akasaka, Naoaki; Yamagata, Ichiro
no journal, ,
The relationship between the addition of minor element and the swelling behavior was investigated using nine heats of Fe-15Cr-20Ni austenitic model alloys, Fe-15Cr-xNi(x = 20, 25 and 30) and a PNC1520 steel irradiated at 480, 570, 620 and 700 C in the Joyo to doses of 20-56 dpa. Phosphorus and boron suppressed the appearance of swelling for these experimental irradiation conditions. Additions of titanium and niobium were effective for suppression of swelling at low temperature, below 570 C. Complicated microstructural dependence of nickel contents for Fe-15Cr-xNi alloys could be seen.
Nakashima, Yosuke*; Ichimura, Kazuya*; Takeda, Hisahito*; Iwamoto, Miki*; Hosoda, Yasunari*; Shimizu, Keita*; Oki, Kensuke*; Sakamoto, Mizuki*; Ono, Noriyasu*; Kado, Shinichiro*; et al.
no journal, ,
no abstracts in English
