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Journal Articles

Study on microwave power dependency of electron spin resonance spectrum of carbonate radicals in teeth

Iwami, Satone*; Yamashita, Takuma*; Mitsuyasu, Yusuke*; Ono, Kenta*; Oka, Toshitaka; Takahashi, Atsushi*; Kino, Yasushi*; Sekine, Tsutomu*; Shimizu, Yoshinaka*; Chiba, Mirei*; et al.

KEK Proceedings 2024-6, p.91 - 95, 2024/12

We aim to improve the detection limit of the ESR dosimetry method. In this study, the saturation behavior of each radical was investigated by varying the microwave power during ESR measurement. Based on the difference in spin relaxation time between carbonate radicals and native radicals, it is expected that the signal-to-noise ratio improves and the detection limit can be lowered when the microwave power is increased to 4.0 mW.

Journal Articles

Improved multicomponent analysis method for electron spin resonance spectra of gamma-irradiated tooth enamel

Yamashita, Takuma*; Iwami, Satone*; Mitsuyasu, Yusuke*; Ono, Kenta*; Oka, Toshitaka; Takahashi, Atsushi*; Kino, Yasushi*; Sekine, Tsutomu*; Shimizu, Yoshinaka*; Chiba, Mirei*; et al.

KEK Proceedings 2024-6, p.85 - 90, 2024/12

To clarify the radiation effects of the accident at the TEPCO's Fukushima Daiichi NPP on living organisms, it is important to accurately estimate the dose to each individual. We have developed a multi-component analysis program using random number optimization to extract only the components derived from carbonate radicals from the ESR spectra.

Journal Articles

Estimation of external dose for wild Japanese macaques captured in Fukushima prefecture; Decomposition of electron spin resonance spectrum

Mitsuyasu, Yusuke*; Oka, Toshitaka; Takahashi, Atsushi*; Kino, Yasushi*; Okutsu, Kenichi*; Sekine, Tsutomu*; Yamashita, Takuma*; Shimizu, Yoshinaka*; Chiba, Mirei*; Suzuki, Toshihiko*; et al.

Radiation Protection Dosimetry, 199(14), p.1620 - 1625, 2023/09

 Times Cited Count:1 Percentile:25.62(Environmental Sciences)

We have been conducting dose assessments for Japanese macaques captured in Fukushima to reveal radiobiological effects on the low-dose expose animals. To accurately determine the external exposure dose, it is desirable to examine the analysis of the CO$$_{2}^{-}$$ radical intensity. We examined ESR spectra of teeth of 10 macaques captured in Fukushima by two spectrum-decomposition algorithms.

Journal Articles

Radiation exposure and oxidative stress status of wild Japanese macaques in the ex-evacuation zone of the Fukushima Daiichi Nuclear Power Plant accident

Ishikawa, Ryoya*; Suzuki, Masatoshi*; Kino, Yasushi*; Endo, Satoru*; Nakajima, Hiroo*; Oka, Toshitaka; Takahashi, Atsushi*; Shimizu, Yoshinaka*; Suzuki, Toshihiko*; Shinoda, Hisashi*; et al.

KEK Proceedings 2022-2, p.61 - 66, 2022/11

The balance between oxidative stress and antioxidant activity, which is a defense mechanism against oxidative stress, was investigated in the liver and bladder of wild Japanese macaques captured in Fukushima Prefecture. No significant induction of oxidative stress by exposure to environmental radionuclides after the Fukushima nuclear accident was observed, suggesting that the stress defense mechanism of the organism is activated in some organs.

Journal Articles

A Study on accuracy of analysis of the radiation-induced component in the ESR spectra of teeth

Mitsuyasu, Yusuke*; Oka, Toshitaka; Takahashi, Atsushi*; Kino, Yasushi*; Okutsu, Kenichi*; Sekine, Tsutomu*; Yamashita, Takuma*; Shimizu, Yoshinaka*; Chiba, Mirei*; Suzuki, Toshihiko*; et al.

KEK Proceedings 2022-2, p.120 - 125, 2022/11

We investigate the effect of sample's anisotropy and measurement condition to obtain the higher reproducibility for the shape of the ESR spectrum and the intensity of CO$$_{2}^{-}$$ radical.

Journal Articles

Tumor radioresistance caused by radiation-induced changes of stem-like cell content and sub-lethal damage repair capability

Fukui, Roman*; Saga, Ryo*; Matsuya, Yusuke; Tomita, Kazuo*; Kuwahara, Yoshikazu*; Ouchi, Kentaro*; Sato, Tomoaki*; Okumura, Kazuhiko*; Date, Hiroyuki*; Fukumoto, Manabu*; et al.

Scientific Reports (Internet), 12(1), p.1056_1 - 1056_12, 2022/01

 Times Cited Count:18 Percentile:91.03(Multidisciplinary Sciences)

Alive cancer cells after fractionated irradiations with 2 Gy X-rays per day for more than 30 days show clinically relevant radioresistant. Such radioresistance is experimentally interpreted to attributed to the increment of stem-like cell content. However, only an experimental approach cannot clarify the cell responses (DNA damage and cell death induction) of cancer stem cells, so the radioresistant mechanisms remain uncertain. In addition to the conventional cell experiments using radio-resistant cell lines established after fractionated irradiations, in this study we developed a mathematical model (so called integrated microdosimetric-kinetic (IMK) model) explicitly considering cancer stem-like cell content and DNA damage responses and investigated radioresistant mechanisms acquired after fractionated irradiations. The IMK model analysis suggested that the changes of stem-like cell fraction and DNA repair efficiency play important roles of radioresisitance acquired after irradiations. Considering these into the IMK model, we successfully reproduced the experimental survival of various cell lines and various irradiation conditions. This work would contribute to not only the precise understanding of the radioresistant mechanisms induced after irradiation but also predicting curative effects with high precision.

Journal Articles

Development of dose estimation method using wild animal teeth for low dose exposure

Mitsuyasu, Yusuke*; Oka, Toshitaka; Takahashi, Atsushi*; Koarai, Kazuma; Kino, Yasushi*; Okutsu, Kenichi*; Sekine, Tsutomu*; Yamashita, Takuma*; Shimizu, Yoshinaka*; Chiba, Mirei*; et al.

KEK Proceedings 2021-2, p.91 - 96, 2021/12

We examined whether the ESR dose estimation method could be applied to wild Japanese macaque. In this work, we investigated the enamel preparation protocol and the analytical method of the ESR spectra.

Journal Articles

Rapid analysis of $$^{90}$$Sr in cattle bone and tooth samples by inductively coupled plasma mass spectrometry

Koarai, Kazuma; Matsueda, Makoto; Aoki, Jo; Yanagisawa, Kayo*; Terashima, Motoki; Fujiwara, Kenso; Kino, Yasushi*; Oka, Toshitaka; Takahashi, Atsushi*; Suzuki, Toshihiko*; et al.

Journal of Analytical Atomic Spectrometry, 36(8), p.1678 - 1682, 2021/08

 Times Cited Count:7 Percentile:53.68(Chemistry, Analytical)

Rapid analysis of $$^{90}$$Sr in bone and tooth samples of cattle were achieved by an inductively coupled plasma mass spectrometry (ICP-MS) coupled with mass shift and solid phase extraction techniques. Limit of detection (LOD) in the ICP-MS measurement of 0.1 g samples was lower than that of the radioactivity measurement. Analytical time of the ICP-MS method was reduced from 20 days to 11 hours, compared with the radiometric method. Therefore, the ICP-MS method can be rapid and useful procedure of $$^{90}$$Sr in small bone and tooth samples derived from terrestrial animals.

Journal Articles

Morphological reproductive characteristics of testes and fertilization capacity of cryopreserved sperm after the Fukushima accident in raccoon (${it Procyon lotor}$)

Komatsu, Kazuki*; Iwasaki, Tsugumi*; Murata, Kosuke*; Yamashiro, Hideaki*; Goh, V. S. T.*; Nakayama, Ryo*; Fujishima, Yohei*; Ono, Takumi*; Kino, Yasushi*; Shimizu, Yoshinaka*; et al.

Reproduction in Domestic Animals, 56(3), p.484 - 497, 2021/03

 Times Cited Count:13 Percentile:83.05(Agriculture, Dairy & Animal Science)

We have established an archive system of livestock and wild animals from the surrounding ex-evacuation zone. Wildlife within the alert zone have been exposed to low-dose-rate (LDR) radiation for a long and continuous time. In this study, we analysed the morphological characteristics of the testes and in vitro fertilization (IVF) capacity of cryopreserved sperm of raccoons from the ex-evacuation zone of the FDNPP accident. This study revealed that the chronic and LDR radiation exposure associated with the FDNPP accident had no adverse effect on the reproductive characteristics and functions of male raccoons.

Journal Articles

External exposure dose estimation by electron spin resonance technique for wild Japanese macaque captured in Fukushima Prefecture

Oka, Toshitaka; Takahashi, Atsushi*; Koarai, Kazuma; Mitsuyasu, Yusuke*; Kino, Yasushi*; Sekine, Tsutomu*; Shimizu, Yoshinaka*; Chiba, Mirei*; Suzuki, Toshihiko*; Osaka, Ken*; et al.

Radiation Measurements, 134, p.106315_1 - 106315_4, 2020/06

 Times Cited Count:9 Percentile:65.08(Nuclear Science & Technology)

The relationship between the CO$$_{2}$$ radical intensity and the absorbed dose (dose response curve) of tooth enamel of Japanese macaque was observed by electron spin resonance and the detection limit of our system was estimated to be 33.5 mGy, which is comparable to the detection limit for human molar teeth. Using the dose response curve, external exposure dose for seven wild Japanese macaques captured in Fukushima prefecture were examined. The results suggest that the external exposure dose for the wild Japanese macaques were ranged between 45 mGy to 300 mGy.

Oral presentation

The Study of oxidative stress status in the organs of wild Japanese macaque affected by the accident of Fukushima Daiichi nuclear power plant

Suzuki, Masatoshi*; Ishikawa, Ryoya*; Oka, Toshitaka; Yamashita, Takuma*; Kino, Yasushi*; Endo, Satoru*; Nakajima, Hiroo*; Sato, Taku*; Isobe, Rio*; Chida, Koichi*; et al.

no journal, , 

no abstracts in English

Oral presentation

Strontium-90 measurement in trace amount of hard tissues for distribution analysis

Koarai, Kazuma; Matsueda, Makoto; Aoki, Jo; Yanagisawa, Kayo*; Fujiwara, Kenso; Terashima, Motoki; Kino, Yasushi*; Oka, Toshitaka; Okutsu, Kenichi*; Yamashita, Takuma*; et al.

no journal, , 

We demonstrated a method of $$^{90}$$Sr measurement in small pieces of hard tissues with radioactivity measurement or ICP-MS measurement. Interference elements of the measurements were removed by chemical separation. We could determine $$^{90}$$Sr in 0.1 g of hard tissues by radioactivity measurement method and ICP-MS method. Limit of detection of the ICP-MS method was lower than that of the radioactivity measurement. The ICP-MS method is adequate method for distribution analysis of $$^{90}$$Sr in the hard tissues.

Oral presentation

Sample preparation procedure for ESR dosimetry using teeth of wild animal

Oka, Toshitaka; Mitsuyasu, Yusuke*; Takahashi, Atsushi*; Koarai, Kazuma; Kino, Yasushi*; Sekine, Tsutomu*; Okutsu, Kenichi*; Yamashita, Takuma*; Shimizu, Yoshinaka*; Chiba, Mirei*; et al.

no journal, , 

Releases of the radioactive materials from the Fukushima Daiichi Nuclear Power Plant accident result in a low dose exposure to wild animals. The external dose of wild animals is commonly estimated by the external dose rate of the captured point, but the estimated exposure dose has huge uncertainties because the size of the habitat and/or the movement of the wild animals are not included in the estimation. To estimate the external dose precisely, we utilize electron spin resonance (ESR) dosimetry. In this work, we investigated the sample preparation procedure of wild animals. The ESR spectrum of enamel of racoon captured in Namie-town, Fukushima has a broad ESR signal due to metal components. The linear relationship between the Co$$_{2}$$ intensity and the absorbed dose that we can apply ESR dosimetry for racoon teeth. Using this relationship, the external exposure dose was estimated.

Oral presentation

Influence on the oxidative stress status in liver and bladder of wild Japanese macaques in response to radiation exposure in the ex-evacuation zone of the Fukushima Daiichi Nuclear Power Plant accident

Ishikawa, Ryoya*; Suzuki, Masatoshi*; Kino, Yasushi*; Endo, Satoru*; Nakajima, Hiroo*; Oka, Toshitaka; Takahashi, Atsushi*; Shimizu, Yoshinaka*; Suzuki, Toshihiko*; Shinoda, Hisashi*; et al.

no journal, , 

In order to investigate the influence on the oxidative stress status by the long-term exposure after the Fukushima Daiichi Nuclear power plant (FNPP) accident, we analyzed oxidative stress markers in liver and bladder of wild Japanese macaques in the ex-evacuation zone. In liver, the concentration of malondialdehyde (MDA) in approximately 70% of the exposed group exceeded the average and SOD activity of the exposed group shifted toward lower within the range indicated in the control group. By contrast, alteration of MDA concentration and SOD activity in bladder was opposite to that shown in liver. We also found that oxidative stress markers changed in the same manner by external and internal exposure. Our data suggested that exposure to low dose/low dose-rate radiation following the FNPP accident may affect the sensitivity to oxidative stress by changing the activity of antioxidant enzymes.

Oral presentation

Rapid analysis of $$^{90}$$Sr in trace amount of bone; Application of inductively coupled plasma mass spectrometry

Koarai, Kazuma; Matsueda, Makoto; Aoki, Jo; Yanagisawa, Kayo*; Terashima, Motoki; Fujiwara, Kenso; Kino, Yasushi*; Oka, Toshitaka; Takahashi, Atsushi*; Suzuki, Toshihiko*; et al.

no journal, , 

Rapid analysis of $$^{90}$$Sr in bone and tooth samples of cattle were achieved by an inductively coupled plasma mass spectrometry (ICP-MS) coupled with mass shift and solid phase extraction techniques. Limit of detection (LOD) in the ICP-MS measurement of 0.1 g samples was lower than that of the radioactivity measurement. Analytical time of the ICP-MS method was reduced from 20 days to 11 hours, compared with the radiometric method. Therefore, the ICP-MS method can be rapid and useful procedure of $$^{90}$$Sr in small bone and tooth samples derived from terrestrial animals.

Oral presentation

Development of analytical method for Sr-90 using ICP-MS; Aim for Sr-90 measurement for otolith

Koarai, Kazuma; Matsueda, Makoto; Aoki, Jo; Yanagisawa, Kayo*; Terashima, Motoki; Fujiwara, Kenso; Kino, Yasushi*; Oka, Toshitaka; Takahashi, Atsushi*; Suzuki, Toshihiko*; et al.

no journal, , 

Rapid analysis of $$^{90}$$Sr in bone and tooth samples of cattle were achieved by an inductively coupled plasma mass spectrometry (ICP-MS) coupled with mass shift and solid phase extraction techniques. Limit of detection (LOD) in the ICP-MS measurement of 0.1 g samples was lower than that of the radioactivity measurement. Analytical time of the ICP-MS method was reduced from 20 days to 11 hours, compared with the radiometric method. The ICP-MS method was improved by ICP-MS/MS and oxygen-ammonia mixed gas reaction.

Oral presentation

Dosimetry of external exposure dose for wild Japanese macaques lived in Fukushima using tooth enamel

Mitsuyasu, Yusuke*; Oka, Toshitaka; Takahashi, Atsushi*; Kino, Yasushi*; Okutsu, Kenichi*; Sekine, Tsutomu*; Yamashita, Takuma*; Shimizu, Yoshinaka*; Chiba, Mirei*; Suzuki, Toshihiko*; et al.

no journal, , 

The Fukushima Daiichi Nuclear Power Plant (FDNPP) accident in 2011 resulted in a release of radionuclides into the environment and caused chronic low-dose-rate exposure to wildlife there. Studies of the radiobiological effects by the chronic low-dose-rate exposure was limited and there is a need for accurate determination of exposure doses and further studies of radiation effects by FDNPP accident. We determined dose of wild animals mainly captured in Namie Town, Fukushima Prefecture from the CO$$_{2}$$ radical intensities in tooth enamel by an electron spin resonance dosimetry.

Oral presentation

Electron spin resonance study of radiation induced radical in hydroperoxide

Yamashita, Takuma*; Mitsuyasu, Yusuke*; Ono, Kenta*; Iwami, Satone*; Oka, Toshitaka; Takahashi, Atsushi*; Kino, Yasushi*; Sekine, Tsutomu*; Shimizu, Yoshinaka*; Chiba, Mirei*; et al.

no journal, , 

In order to clarify the radiation effects of the Fukushima Daiichi Nuclear Power Plant accident on living organisms, it is important to estimate the radiation dose to individual organisms. We have focused on carbonate radicals that induced in tooth enamel due to radiation, and have estimated the dose by using electron spin resonance technique. In this presentation, we report the results of dose response of radiation-induced radicals and the application of this method to low-dose area by using tooth enamel of Japanese macaque and hydroxyapatite.

Oral presentation

Dose estimation using ESR for wild Japanese macaque in contaminated area of Fukushima Prefecture

Oka, Toshitaka; Suzuki, Masatoshi*; Takahashi, Atsushi*; Sato, Taku*; Mitsuyasu, Yusuke*; Kino, Yasushi*; Okutsu, Kenichi*; Sekine, Tsutomu*; Yamashita, Takuma*; Shimizu, Yoshinaka*; et al.

no journal, , 

We examined ESR measurement to estimate the dose of wild Japanese macaque captured at the contaminated area of Fukushima Prefecture. The estimated doses were ranged from several mGy to ~270 mGy, which are comparable to the estimated dose reported in our previous work, suggesting that the maximum dose of wild Japanese macaques captured in this area is estimated to be about 300 mGy. The dose estimation using a novel deconvolution program developed by ourselves will be also discussed.

Oral presentation

Analysis of electron spin resonance spectrum of gamma-ray irradiated tooth enamel

Yamashita, Takuma*; Mitsuyasu, Yusuke*; Ono, Kenta*; Iwami, Satone*; Hayashi, Teppei*; Kino, Yasushi*; Sekine, Tsutomu*; Oka, Toshitaka; Takahashi, Atsushi*; Shimizu, Yoshinaka*; et al.

no journal, , 

no abstracts in English

31 (Records 1-20 displayed on this page)