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Fukunaga, Hisanori*; Matsuya, Yusuke; Tokuue, Koichi*; Omura, Motoko*
British Journal of Radiology, 93(1111), p.20200311_1 - 20200311_4, 2020/07
Times Cited Count:3 Percentile:73.58(Radiology, Nuclear Medicine & Medical Imaging)Boron neutron capture therapy (BNCT) has attracted attention as a selective treatment approach for cancer cells while sparing surrounding normal cells. The basic concept of BNCT was developed in the 1930s, but it has not yet been commonly popular in clinical practice, even though there is now a large number of experimental and translational studies demonstrating its marked therapeutic potential. With the development of neutron accelerators that can be installed in medical institutions, accelerator-based BNCT is expected to become available at several medical institutes around the world in the near future. In this commentary, from the point of view of microdosimetry, we discuss the biological effects of BNCT, especially the underlying mechanisms of cell responses. The recent development of new treatment methods that combine proton beam sources and BNCT technology is expected to contribute significantly improving the prognosis of cancer treatment in the near future. Therefore, radiobiologists in the field of BNCT and related techniques will have a significant role to play in creating synergy effects in clinical oncology.
Tang, T. L.*; Uesaka, Tomohiro*; Kawase, Shoichiro; Beaumel, D.*; Dozono, Masanori*; Fujii, Toshihiko*; Fukuda, Naoki*; Fukunaga, Taku*; Galindo-Uribarri, A.*; Hwang, S. H.*; et al.
Physical Review Letters, 124(21), p.212502_1 - 212502_6, 2020/05
Times Cited Count:14 Percentile:74.18(Physics, Multidisciplinary)The structure of a neutron-rich F nucleus is investigated by a quasifree () knockout reaction. The sum of spectroscopic factors of orbital is found to be 1.0 0.3. The result shows that the O core of F nucleus significantly differs from a free O nucleus, and the core consists of 35% O, and 65% excited O. The result shows that the O core of F nucleus significantly differs from a free O nucleus. The result may infer that the addition of the proton considerably changes the neutron structure in F from that in O, which could be a possible mechanism responsible for the oxygen dripline anomaly.
Saito, Junichi; Ara, Kuniaki; Nagai, Keiichi; Nishimura, Masahiro; Onojima, Takamitsu; Sugiyama, Kenichiro*; Zhang, Z.*; Kitagawa, Hiroshi*; Nakano, Haruyuki*; Oka, Nobuki*; et al.
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Saito, Junichi; Ara, Kuniaki; Ogata, Kan*; Fukunaga, Koichi*; Oka, Nobuki*; Kitagawa, Hiroshi*; Yamauchi, Miho*
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Saito, Junichi; Ara, Kuniaki; Fukunaga, Koichi*; Ogata, Kan*; Nagai, Masahiko*; Oka, Nobuki*; Kitagawa, Hiroshi*; Yamauchi, Miho*
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Saito, Junichi; Ara, Kuniaki; Nagai, Masahiko*; Fukunaga, Koichi*; Kitagawa, Hiroshi*; Yamauchi, Miho*; Oka, Nobuki*
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Saito, Junichi; Ara, Kuniaki; Fukunaga, Koichi*; Oka, Nobuki*; Nagai, Masahiko*
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Saito, Junichi; Fukunaga, Koichi*; Oka, Nobuki*; Nagai, Masahiko*; Ara, Kuniaki
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Fukunaga, Koichi*; Nagai, Masahiko*; Ara, Kuniaki; Saito, Junichi
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Saito, Junichi; Fukunaga, Koichi*
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