Development of advanced inductive scenarios for ITER

Luce, T. C.*; Challis, C. D.*; Ide, Shunsuke; Joffrin, E.*; Kamada, Yutaka; Politzer, P. A.*; Schweinzer, J.*; Sips, A. C. C.*; Stober, J.*; Giruzzi, G.*; et al.

Nuclear Fusion, 54(1), p.013015_1 - 013015_15, 2013/12

https://doi.org/10.1088/0029-5515/54/1/013015

Progress with DC photoemission electron sources

Dunham, B.*; Benson, S.*; Hernandez-Garcia, C.*; Suleiman, R.*; Nishimori, Nobuyuki; Rao, T.*; Yamamoto, Masahiro*

Proceedings of 50th ICFA Advanced Beam Dynamics Workshop on Energy Recovery Linacs (ERL '11) (Internet), p.10 - 29, 2011/10

http://accelconf.web.cern.ch/accelconf/ERL2011/papers/wg1000.pdf

Integrated modeling of steady-state scenarios and heating and current drive mixes for ITER

Murakami, Masanori*; Park, J. M.*; Giruzzi, G.*; Garcia, J.*; Bonoli, P.*; Budny, R. V.*; Doyle, E. J.*; Fukuyama, Atsushi*; Hayashi, Nobuhiko; Honda, Mitsuru; et al.

Proceedings of 23rd IAEA Fusion Energy Conference (FEC 2010) (CD-ROM), 8 Pages, 2011/03

http://www-naweb.iaea.org/napc/physics/FEC/FEC2010/html/node76.htm#18822

FIREX project and effects of self-generated electric and magnetic fields on electron-driven fast ignition

Mima, Kunioki*; Sunahara, Atsushi*; Shiraga, Hiroyuki*; Nishimura, Hiroaki*; Azechi, Hiroshi*; Nakamura, Tatsufumi; Jozaki, Tomoyuki*; Nagatomo, Hideo*; Garcia, C.*; Veralde, P.*

Plasma Physics and Controlled Fusion, 52(12), p.124047_1 - 124047_6, 2010/12

https://doi.org/10.1088/0741-3335/52/12/124047

Fast ignition is a new scheme in laser fusion, in which higher energy gain with a smaller laser pulse energy is expected. At Osaka University, a laser with four beams and a total output of 10 kJ ps-1, laser for fast ignition experiment (LFEX), has been constructed and we have carried out an integrated experiment with one beam of the LFEX. Through experiments it was found that the coupling efficiency is degraded when the laser pre-pulse is not sufficiently small. Furthermore, the distance between the hot electron source and the core plasma is large. In this paper it is proposed that a thin foil covers the laser entrance of the cone to mitigate the pre-plasma and a double cone reduces the loss of high energy electrons from the side wall of the cone. The simulations indicate that a higher coupling efficiency is expected for the double cone target with a thin foil at the laser entrance.

Distinct structural requirements for interleukin-4 (IL-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiveness

Ito, Takachika*; Suzuki, Shoichi*; Kanaji, Sachiko*; Shiraishi, Hiroshi*; Ota, Shoichiro*; Arima, Kazuhiko*; Tanaka, Go*; Tamada, Taro; Honjo, Eijiro*; Garcia, K. C.*; et al.

Journal of Biological Chemistry, 284(36), p.24289 - 24296, 2009/09

https://doi.org/10.1074/jbc.M109.007286

Both IL-4 and IL-13 can bind to the shared receptor composed of the IL-4 receptor chain and the IL-13 receptor -1 chain (IL-13R1); however, the assembly mechanisms of these ligands to the receptor is different, enabling the principal functions of these ligands to be different. We have previously shown that the N-terminal Ig-like domain in IL-13R1, called the D1 domain, is the specific and critical binding unit for IL-13. However, it has still remained obscure which the amino acid has specific binding capacity to IL-13 and why the D1 domain acts as the binding site for IL-13, but not IL-4. To address these questions, in this study, we performed the mutational analyses for the D1 domain, combining the structural data to identify the amino acids critical for binding to IL-13. Mutations of Lys76, Lys77, or Ile78 in c' strand in which the crystal structure showed interact with IL-13 and those of Trp65 and Ala79 adjacent to the interacting site, resulted in significant impairment of IL-13 binding, demonstrating that these amino acids generate the binding site. Furthermore, mutations of Val35, Leu38, or Val42 at N-terminal -strand also resulted in loss of IL-13 binding, probably from decrease structural stability. None of the mutations employed here affected IL-4 binding. These results demonstrate that the hydrophobic patch composed of Lys76, Lys77, and Ile78 is the IL-13 recognition site and solidify our understanding that the differential requirements of the D1 domain in IL-13R1 allows the shared receptor to respond differentially to IL-4 and IL-13.

Integrated modeling of steady-state scenarios for ITER; Physics and computational challenges

Giruzzi, G.*; Park, J. M.*; Murakami, M.*; Kessel, C. E.*; Polevoi, A.*; Sips, A. C. C.*; Artaud, J. F.*; Basiuk, V.*; Bonoli, P.*; Budny, R. V.*; et al.

Proceedings of 22nd IAEA Fusion Energy Conference (FEC 2008) (CD-ROM), 8 Pages, 2008/10

Photocathodes for the energy recovery linacs

Rao, T.*; Burrill, A.*; Chang, X. Y.*; Smedley, J.*; Nishitani, Tomohiro; Hernandez Garcia, C.*; Poelker, M.*; Seddon, E.*; Hannon, F. E.*; Sinclair, C. K.*; et al.

Nuclear Instruments and Methods in Physics Research A, 557(1), p.124 - 130, 2006/02

https://doi.org/10.1016/j.nima.2005.10.112

In the past few years, there has been considerable interest in using an energy recovery linac (ERL) for future light sources and high-energy nuclear physics. The electron beam requirements of the ERLs under consideration span a wide range in parameters such as current, current density, frequency, operating temperatures, accelerating gradients etc. The design of the injector, whether it is normal conducting or superconducting, DC or RF, average current, temporal profile of the electron bunch all play key role in the choice of the photocathode. In this paper, we attempt to provide an overview of the available cathode materials, the pros and cons associated with each and the electron beam parameters they can provide.