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Hata, Kuniki; Lin, M.*; Yokoya, Akinari*; Fujii, Kentaro*; Yamashita, Shinichi*; Muroya, Yusa*; Katsumura, Yosuke*
Hoshasen Kagaku (Internet), (103), p.29 - 34, 2017/04
Reactivity of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), which is known to show high antioxidative properties, with oxidative species, such as hydroxyl radical (
OH) and azide radical (N
), was investigated by a pulse radiolysis experiment, and generation behavior of edaravone radicals produced through these reactions were observed. It was shown that OH-adducts are produced by the reaction with OH in contrast to the other oxidative radicals, which react with edaravone by an electron transfer reaction. Chemical repair properties of edaravone against DNA lesions produced by reactions of DNA with oxidative species were also investigated by a pulse radiolysis experiment with deoxyguanosine monophosphate (dGMP) and a 
-radiolysis experiment with plasmid DNA solutions. It was observed that edaravone reduced dGMP radicals just after produced in a dilute aqueous solution and inhibited some base lesions on plasmid DNA more effectively than single strand breaks. These results show that edaravone may protect living system from oxidative stress, such as radiation, by not only scavenging oxidative species but also reducing precursors of DNA leisons.
Hata, Kuniki; Kido, Kentaro; Nishiyama, Yutaka; Maruyama, Yu
NEA/CSNI/R(2016)5 (Internet), p.196 - 203, 2016/05
Kido, Kentaro; Hata, Kuniki; Maruyama, Yu; Nishiyama, Yutaka; Hoshi, Harutaka*
NEA/CSNI/R(2016)5 (Internet), p.204 - 212, 2016/05
Fu, H. Y.*; Lin, M.; Katsumura, Yosuke*; Yokoya, Akinari; Hata, Kuniki; Muroya, Yusa*; Fujii, Kentaro; Shikazono, Naoya
Acta Biochimica et Biophysica Sinica, 42(7), p.489 - 495, 2010/07
Times Cited Count：12 Percentile：30.14(Biochemistry & Molecular Biology)Silybin (SLB) and similar analogues, namely, hesperetin (HESP), naringenin (NAN) and naringin (NAR), are believed to be active constituents of natural flavonoids that have been reported as chemopreventive agents for certain cancers. Moreover, SLB and analogues have been determined to fast repair DNA bases from oxidative damage by pulse radiolysis techniques. The present study was designed to evaluate the protective effects of SLB and analogues on soft X-ray-induced damage to plasmid DNA in vitro. Among the compounds tested, HESP and SLB were the most effective in preventing X-ray-induced formation of DNA single-strand breaks (SSB). A comparison of these results with other experiments showed that the ability of SLB and analogues to inhibit DNA damage in vitro correlated with the ability of the compounds to scavenge free radicals. Our work revealed that natural flavonoids, SLB and analogues may be used as potent protectors against radiation damage.
Fu, H.*; Katsumura, Yosuke; Lin, M.; Muroya, Yusa*; Hata, Kuniki; Fujii, Kentaro; Yokoya, Akinari; Hatano, Yoshihiko
Radiation Physics and Chemistry, 78(12), p.1192 - 1197, 2009/12
Times Cited Count：33 Percentile：87.49(Chemistry, Physical)Masaki, Kei; Sugiyama, Kazuyoshi*; Hayashi, Takao; Ochiai, Kentaro; Goto, Yoshitaka*; Shibahara, Takahiro*; Hirohata, Yuko*; Oya, Yasuhisa*; Miya, Naoyuki; Tanabe, Tetsuo*
Journal of Nuclear Materials, 337-339, p.553 - 559, 2005/03
Times Cited Count：26 Percentile：83.31(Materials Science, Multidisciplinary)no abstracts in English
Mizuki, Junichiro; Konishi, Hiroyuki; Nishihata, Yasuo; Takahashi, Masamitsu; Suzuya, Kentaro; Matsumoto, Norimasa; Yoneda, Yasuhiro
Nihon Kessho Gakkai-Shi, 42(1), p.68 - 75, 2000/02
no abstracts in English
Cs(n,)
Cs; Fundamental data for the transmutation of nuclear wasteHatsukawa, Yuichi*; Shinohara, Nobuo*; Hata, Kentaro*; Kobayashi, Katsunori*; Motoishi, Shoji*; Tanase, Masakazu*; Kato, Toshio; Nakamura, Shoji; Harada, Hideo
Journal of Radioanalytical and Nuclear Chemistry, 239(3), p.455 - 458, 1999/03
Times Cited Count：2 Percentile：20.95(Chemistry, Analytical)no abstracts in English
Cs(n,)CsKato, Toshio; Nakamura, Shoji; Harada, Hideo; Hatsukawa, Yuichi*; Shinohara, Nobuo*; Hata, Kentaro*; Kobayashi, Katsunori*; Motoishi, Shoji*; Tanase, Masakazu*
Journal of Nuclear Science and Technology, 34(5), p.431 - 438, 1997/05
no abstracts in English
Kato, Toshio; Nakamura, Shoji; Harada, Hideo; Hatsukawa, Yuichi*; Shinohara, Nobuo*; Hata, Kentaro*; Kobayashi, Katsunori*; Motoishi, Shoji*; Tanase, Masakazu*
Italian Physical Society Conference Proceedings 59, p.1335 - 1337, 1997/00
no abstracts in English
Fu, H.*; Katsumura, Yosuke; Lin, M.; Muroya, Yusa*; Hata, Kuniki; Fujii, Kentaro; Yokoya, Akinari
no journal, ,
The transient spectral properties and rate constants of the free radical scavenger carnosine reacting with various one-electron oxidants such as 
OH, Br
, N, and CClOO have been studied by pulse radiolysis techniques. Carnosine and its related compounds (CRC) also offer protection to plasmid DNA against X-ray radiation induced damages. Our data demonstrated that carnosine and CRC may play an important role in the maintenance of the antioxidant system.
" DNA protective properties of Silybin and analogues against X-ray radiationFu, H.*; Lin, M.; Hata, Kuniki; Muroya, Yusa*; Fujii, Kentaro; Katsumura, Yosuke; Yokoya, Akinari; Shikazono, Naoya; Hatano, Yoshihiko
no journal, ,
Natural flavonoids such as silybin (SLB) are believed to be active constituents of plants accounting for the reported chemoprevention of certain cancers. However, molecular mechanisms by which the low-concentration SLB and analogues in human can reduce the incidence are not clear. Using an 
plasmid DNA system with radiolytically generated reactive oxygen species (ROS) under constant scavenging conditions, it was shown that the tested flavonoids can ameliorate free radical damage sustained by DNA. The dose modifying factor for 0.1 mM SLB for 50% protection of plasmid DNA was found to be 8.9. SLB was the most active among the tested flavonoids, with effects seen at 
M. Combined fast-reaction chemistry studies support a mechanism of electron transfer (or H-atom transfer) from SLB to ROS-induced radical sites on DNA. These results support an antioxidant role for SLB and analogues in the direct interaction with DNA radicals.
Kido, Kentaro; Hata, Kuniki; Maruyama, Yu
no journal, ,
no abstracts in English
